Glicina per Insonnia
A Evidenze Più grandi trial clinici mostrano in modo costante benefici significativi.Basato su 36 studi (2 meta-analyses, 6 RCTs) con 484,248 partecipanti totali. 22/36 studi mostrano effetti positivi.
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A
In sintesi
Glycine is supported by strong evidence as a supplement that may help improve overall sleep quality, with benefits seen in multiple well-designed clinical trials.
- 22 out of 36 studies show positive effects, with 6 RCTs and 2 meta-analyses
- Glycine may promote sleep by lowering core body temperature, a natural sleep trigger
- A 2024 RCT showed collagen peptides (glycine-rich) reduced sleep fragmentation
- Large evidence base of over 484,000 participants across all study types
Key Study Findings
basic science
Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA.
Dose: Lactobacillus reuteri E9 (dose not specified)
vs: Placebo
Effetto: None
< 0.05
systematic review
n=451
Double-blind
Effectiveness of Homoeopathic Treatments for Sleep Disorders in Children and Adolescents: A Systematic Review According …
Dose: various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa
vs: Placebo
Effetto: bruxism: ΔVAS -2.36 vs -1.72; enuresis: median -2.4 nights/week
0.05 (bruxism); < 0.04 (enures
In vitro
The Glycine-Rich Region as a Flexible Molecular Glue Promoting hPrP106-145 Aggregation into β-Sheet Structures.
Dose: None
vs: Placebo
Effetto: None
None
basic science
Time-specific study on the efficacy of stems and leaves of Arachis hypogaea L. targeting glycine/serine …
Dose: Arachis hypogaea L. stems and leaves extract
vs: Placebo
Effetto: None
None
randomized controlled trial
n=13
1 weeks
Double-blind
Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active …
Dose: 15 g/day collagen peptides (glycine-rich) consumed 1 hour before bedtime for 7 nights
vs: Placebo
Effetto: None
0.028
animal experimental
3 weeks
Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice.
Dose: None
vs: Placebo
Effetto: None
None
Key Statistics
36
Studi
483763
Partecipanti
↑
Positive
A
Grado
Referenced Papers
Pharmaceuticals (Basel, Switzerland)
2026
Journal of chemical …
2025
3 citazioni
Children (Basel, Switzerland)
2025
Frontiers in bioscience …
2025
Journal of pharmaceutical …
2025
European journal of …
2024
10 citazioni
Journal of ethnopharmacology
2024
6 citazioni
Human genetics
2023
17 citazioni
Neurological sciences : …
2023
9 citazioni
International journal of …
2023
8 citazioni
Journal of biomolecular …
2023
3 citazioni
Journal of the …
2022
55 citazioni
Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies.
Case Report
Brain sciences
2020
12 citazioni
BioMed research international
2019
19 citazioni
Clinical cancer research …
2018
65 citazioni
Leukemia research
2018
35 citazioni
Electronic physician
2017
102 citazioni
Sleep medicine reviews
2017
99 citazioni
BMC psychiatry
2016
26 citazioni
Addictive behaviors
2016
3 citazioni
Molecular neurobiology
2016
Fitoterapia
2015
55 citazioni
Acta biochimica et …
2013
25 citazioni
Frontiers in neurology
2012
27 citazioni
Psychiatry and clinical …
2011
23 citazioni
Human mutation
2009
136 citazioni
Interactions of mineralocorticoids and glucocorticoids in epithelial target tissues revisited.
Review
Steroids
2009
11 citazioni
Current drug delivery
2009
1 citazioni
Nutritional neuroscience
2008
73 citazioni
Journal of medical …
2008
33 citazioni
British journal of …
2006
351 citazioni
Minerva ginecologica
2006
British journal of …
2005
3 citazioni
Neurology
2002
56 citazioni
Alternative medicine review …
1998
58 citazioni
Clinical neuropharmacology
1994
18 citazioni
European journal of …
1986
22 citazioni
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosaggi di uso comune
- sleep:
- 3 g, 1 hour before bed
Limite massimo: Not established; studied up to 9 g/day
Dosaggi studiati nella ricerca
| Dosaggio | Durata | Effetto | N |
|---|---|---|---|
| Lactobacillus reuteri E9 (dose not specified) | -- | Positive | -- |
| various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa | -- | Positive | 451 |
| None | -- | Neutral | -- |
| Arachis hypogaea L. stems and leaves extract | -- | Positive | -- |
| 15 g/day collagen peptides (glycine-rich) consumed 1 hour before bedtime for 7 nights | 1 weeks | Positive | 13 |
| None | 3 weeks | Positive | -- |
| not applicable | -- | Neutral | 17 |
| None | -- | Mixed | 482730 |
Momento migliore per l'assunzione: 1 hour before bed
Safety & Side Effects
Effetti collaterali segnalati
- ⚠ Nausea
- ⚠ Soft stools
- ⚠ Mild drowsiness
Interazioni note
- ● Clozapine — glycine may reduce effectiveness of this antipsychotic
- ● Antihypertensives — potential additive blood pressure lowering
Livello di assunzione massimo tollerabile: Not established; studied up to 9 g/day
Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
Frequently Asked Questions
Does Glicina help with Insonnia?
Based on 36 studies with 483,763 participants, there is strong evidence from multiple clinical trials that Glicina may support Insonnia management. Our evidence grade is A (Strong Evidence).
How much Glicina should I take for Insonnia?
Studies have used various dosages. A commonly studied range is 3 g, 1 hour before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Glicina?
Reported side effects may include Nausea, Soft stools, Mild drowsiness. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Glicina and Insonnia?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 36 peer-reviewed studies with 483,763 total participants. The overall direction of effect is positive.
Related Evidence
Altri ingredienti per Insonnia
Glicina per altre condizioni
References
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