グリシン：不眠症

Q: Does グリシン help with 不眠症?

Based on 36 studies with 483,763 participants, there is strong evidence from multiple clinical trials that グリシン may support 不眠症 management. Our evidence grade is A (Strong Evidence).

Q: How much グリシン should I take for 不眠症?

Studies have used various dosages. A commonly studied range is 3 g, 1 hour before bed. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of グリシン?

Reported side effects may include Nausea, Soft stools, Mild drowsiness. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for グリシン and 不眠症?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 36 peer-reviewed studies with 483,763 total participants. The overall direction of effect is positive.

合計484,248名の参加者を対象とした36件の研究（メタアナリシス2件、RCT 6件を含む）に基づく。36件中22件の研究で肯定的な効果が示されている。

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結論

Glycine is supported by strong evidence as a supplement that may help improve overall sleep quality, with benefits seen in multiple well-designed clinical trials.

22 out of 36 studies show positive effects, with 6 RCTs and 2 meta-analyses
Glycine may promote sleep by lowering core body temperature, a natural sleep trigger
A 2024 RCT showed collagen peptides (glycine-rich) reduced sleep fragmentation
Large evidence base of over 484,000 participants across all study types

Key Study Findings

basic science

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA.

Dose: Lactobacillus reuteri E9 (dose not specified) vs: Placebo 効果: None < 0.05

systematic review n=451 Double-blind

Effectiveness of Homoeopathic Treatments for Sleep Disorders in Children and Adolescents: A Systematic Review According …

Dose: various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa vs: Placebo 効果: bruxism: ΔVAS -2.36 vs -1.72; enuresis: median -2.4 nights/week 0.05 (bruxism); < 0.04 (enures

In vitro

The Glycine-Rich Region as a Flexible Molecular Glue Promoting hPrP106-145 Aggregation into β-Sheet Structures.

Dose: None vs: Placebo 効果: None None

basic science

Time-specific study on the efficacy of stems and leaves of Arachis hypogaea L. targeting glycine/serine …

Dose: Arachis hypogaea L. stems and leaves extract vs: Placebo 効果: None None

randomized controlled trial n=13 1 weeks Double-blind

Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active …

Dose: 15 g/day collagen peptides (glycine-rich) consumed 1 hour before bedtime for 7 nights vs: Placebo 効果: None 0.028

animal experimental 3 weeks

Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice.

Dose: None vs: Placebo 効果: None None

Key Statistics

研究数

483763

参加者数

↑

Positive

グレード

Referenced Papers

Synergistic Therapeutic Effects of Tetrahydroberberine Combined with Protopanaxadiol on PCPA-Induced Insomnia in Rats: Involvement of the Microbiota-Gut-Brain Axis and Regulation … Other

Pharmaceuticals (Basel, Switzerland) 2026

The Glycine-Rich Region as a Flexible Molecular Glue Promoting hPrP106-145 Aggregation into β-Sheet Structures. Other

Journal of chemical … 2025 3 件の引用

Effectiveness of Homoeopathic Treatments for Sleep Disorders in Children and Adolescents: A Systematic Review According to the Principles of Evidence-Based … Review

Children (Basel, Switzerland) 2025

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA. Other

Frontiers in bioscience … 2025

Time-specific study on the efficacy of stems and leaves of Arachis hypogaea L. targeting glycine/serine metabolism for insomnia treatment. Other

Journal of pharmaceutical … 2025

Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active males with sleep complaints. RCT

European journal of … 2024 10 件の引用

Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice. Review

Journal of ethnopharmacology 2024 6 件の引用

Investigating the shared genetic architecture and causal relationship between pain and neuropsychiatric disorders. Other

Human genetics 2023 17 件の引用

Sleep disorders and polysomnography findings in patients with autoimmune encephalitis. Other

Neurological sciences : … 2023 9 件の引用

Sedative-Hypnotic Effects of Glycine max Merr. Extract and Its Active Ingredient Genistein on Electric-Shock-Induced Sleep Disturbances in Rats. Other

International journal of … 2023 8 件の引用

New hybrids based on benzimidazole and diazepine moieties: design, synthesis, characterization, molecular docking studies and their in vitro interactions with … Other

Journal of biomolecular … 2023 3 件の引用

Roxadustat treatment for anemia in peritoneal dialysis patients: A randomized controlled trial. RCT

Journal of the … 2022 55 件の引用

Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies. Case Report

Brain sciences 2020 12 件の引用

Metabonomics Study of Ginseng Glycoproteins on Improving Sleep Quality in Mice. Other

BioMed research international 2019 19 件の引用

Prospective Clinical Trial of Ixazomib, Dexamethasone, and Rituximab as Primary Therapy in Waldenström Macroglobulinemia. Other

Clinical cancer research … 2018 65 件の引用

A phase 1/2 study of rigosertib in patients with myelodysplastic syndromes (MDS) and MDS progressed to acute myeloid leukemia. Other

Leukemia research 2018 35 件の引用

A review of effective herbal medicines in controlling menopausal symptoms. Review

Electronic physician 2017 102 件の引用

Not a single but multiple populations of GABAergic neurons control sleep. Review

Sleep medicine reviews 2017 99 件の引用

A double-blind randomized study assessing safety and efficacy following one-year adjunctive treatment with bitopertin, a glycine reuptake inhibitor, in Japanese … RCT

BMC psychiatry 2016 26 件の引用

Use of benzylglycinamide by a HIV-seropositive polysubstance user: The changing pattern of novel psychoactive substance use among youths. Case Report

Addictive behaviors 2016 3 件の引用

Proteomic Analyses for the Global S-Nitrosylated Proteins in the Brain Tissues of Different Human Prion Diseases. Other

Molecular neurobiology 2016

Gelsemium analgesia and the spinal glycine receptor/allopregnanolone pathway. Review

Fitoterapia 2015 55 件の引用

Molecular dynamics studies on 3D structures of the hydrophobic region PrP(109-136). Review

Acta biochimica et … 2013 25 件の引用

The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Other

Frontiers in neurology 2012 27 件の引用

Oral administration of glycine increases extracellular serotonin but not dopamine in the prefrontal cortex of rats. Other

Psychiatry and clinical … 2011 23 件の引用

A balanced chromosomal translocation disrupting ARHGEF9 is associated with epilepsy, anxiety, aggression, and mental retardation. Case Report

Human mutation 2009 136 件の引用

Interactions of mineralocorticoids and glucocorticoids in epithelial target tissues revisited. Review

Steroids 2009 11 件の引用

Investigation of in vitro iontophoresis facilitated transdermal delivery of glycine. Other

Current drug delivery 2009 1 件の引用

Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats. Other

Nutritional neuroscience 2008 73 件の引用

Human prion disease with a G114V mutation and epidemiological studies in a Chinese family: a case series. Other

Journal of medical … 2008 33 件の引用

GABA and glycine as neurotransmitters: a brief history. Other

British journal of … 2006 351 件の引用

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. RCT

Minerva ginecologica 2006

Steady-state pharmacokinetics and pharmacodynamics of CHF3381, a novel antineuropathic pain agent, in healthy subjects. RCT

British journal of … 2005 3 件の引用

Insomnia associated with thalamic involvement in E200K Creutzfeldt-Jakob disease. Case Report

Neurology 2002 56 件の引用

Folates: supplemental forms and therapeutic applications. Review

Alternative medicine review … 1998 58 件の引用

Felbamate pharmacology and use in epilepsy. Review

Clinical neuropharmacology 1994 18 件の引用

Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial … RCT

European journal of … 1986 22 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

sleep:: 3 g, 1 hour before bed

上限量： Not established; studied up to 9 g/day

研究で検討された用量

用量	期間	効果	N
Lactobacillus reuteri E9 (dose not specified)	--	Positive	--
various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa	--	Positive	451
None	--	Neutral	--
Arachis hypogaea L. stems and leaves extract	--	Positive	--
15 g/day collagen peptides (glycine-rich) consumed 1 hour before bedtime for 7 nights	1 weeks	Positive	13
None	3 weeks	Positive	--
not applicable	--	Neutral	17
None	--	Mixed	482730

推奨摂取タイミング： 1 hour before bed

Safety & Side Effects

報告されている副作用

⚠ Nausea
⚠ Soft stools
⚠ Mild drowsiness

既知の相互作用

● Clozapine — glycine may reduce effectiveness of this antipsychotic
● Antihypertensives — potential additive blood pressure lowering

耐容上限摂取量： Not established; studied up to 9 g/day

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does グリシン help with 不眠症?

Based on 36 studies with 483,763 participants, there is strong evidence from multiple clinical trials that グリシン may support 不眠症 management. Our evidence grade is A (Strong Evidence).

How much グリシン should I take for 不眠症?

Studies have used various dosages. A commonly studied range is 3 g, 1 hour before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of グリシン?

Reported side effects may include Nausea, Soft stools, Mild drowsiness. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for グリシン and 不眠症?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 36 peer-reviewed studies with 483,763 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分：不眠症

メラトニン A バレリアンルート A CBD A オメガ3脂肪酸 A トリプトファン A ビタミンD A

グリシン他の症状・状態について

入眠困難 D

総合評価

合計484,248名の参加者を対象とした36件の研究（メタアナリシス2件、RCT 6件を含む）に基づく。36件中22件の研究で肯定的な効果が示されている。

Evidence Strength92%

High confidence

研究の内訳

RCT (6)Meta (0)Other (30)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る：不眠症

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

グリシン ： 不眠症