Glycine para Insomnio
A Evidencia Múltiples ensayos clínicos de gran tamaño muestran de forma consistente beneficios significativos.Basado en 36 estudios (2 meta-analyses, 6 RCTs) con 484,248 participantes en total. 22/36 estudios muestran efectos positivos.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'sleepcited.com';
const params = 'ingredient\u003Dglycine\u0026condition\u003Dinsomnia';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
A
Conclusión
Glycine is supported by strong evidence as a supplement that may help improve overall sleep quality, with benefits seen in multiple well-designed clinical trials.
- 22 out of 36 studies show positive effects, with 6 RCTs and 2 meta-analyses
- Glycine may promote sleep by lowering core body temperature, a natural sleep trigger
- A 2024 RCT showed collagen peptides (glycine-rich) reduced sleep fragmentation
- Large evidence base of over 484,000 participants across all study types
Key Study Findings
basic science
Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA.
Dose: Lactobacillus reuteri E9 (dose not specified)
vs: Placebo
Efecto: None
< 0.05
systematic review
n=451
Double-blind
Effectiveness of Homoeopathic Treatments for Sleep Disorders in Children and Adolescents: A Systematic Review According …
Dose: various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa
vs: Placebo
Efecto: bruxism: ΔVAS -2.36 vs -1.72; enuresis: median -2.4 nights/week
0.05 (bruxism); < 0.04 (enures
In vitro
The Glycine-Rich Region as a Flexible Molecular Glue Promoting hPrP106-145 Aggregation into β-Sheet Structures.
Dose: None
vs: Placebo
Efecto: None
None
basic science
Time-specific study on the efficacy of stems and leaves of Arachis hypogaea L. targeting glycine/serine …
Dose: Arachis hypogaea L. stems and leaves extract
vs: Placebo
Efecto: None
None
randomized controlled trial
n=13
1 weeks
Double-blind
Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active …
Dose: 15 g/day collagen peptides (glycine-rich) consumed 1 hour before bedtime for 7 nights
vs: Placebo
Efecto: None
0.028
animal experimental
3 weeks
Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice.
Dose: None
vs: Placebo
Efecto: None
None
Key Statistics
36
Estudios
483763
Participantes
↑
Positive
A
Calificación
Referenced Papers
Pharmaceuticals (Basel, Switzerland)
2026
Journal of chemical …
2025
3 citas
Children (Basel, Switzerland)
2025
Frontiers in bioscience …
2025
Journal of pharmaceutical …
2025
European journal of …
2024
10 citas
Journal of ethnopharmacology
2024
6 citas
Human genetics
2023
17 citas
Neurological sciences : …
2023
9 citas
International journal of …
2023
8 citas
Journal of biomolecular …
2023
3 citas
Journal of the …
2022
55 citas
Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies.
Case Report
Brain sciences
2020
12 citas
BioMed research international
2019
19 citas
Clinical cancer research …
2018
65 citas
Leukemia research
2018
35 citas
Electronic physician
2017
102 citas
Sleep medicine reviews
2017
99 citas
BMC psychiatry
2016
26 citas
Addictive behaviors
2016
3 citas
Molecular neurobiology
2016
Fitoterapia
2015
55 citas
Acta biochimica et …
2013
25 citas
Frontiers in neurology
2012
27 citas
Psychiatry and clinical …
2011
23 citas
Human mutation
2009
136 citas
Interactions of mineralocorticoids and glucocorticoids in epithelial target tissues revisited.
Review
Steroids
2009
11 citas
Current drug delivery
2009
1 citas
Nutritional neuroscience
2008
73 citas
Journal of medical …
2008
33 citas
British journal of …
2006
351 citas
Minerva ginecologica
2006
British journal of …
2005
3 citas
Neurology
2002
56 citas
Alternative medicine review …
1998
58 citas
Clinical neuropharmacology
1994
18 citas
European journal of …
1986
22 citas
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosificaciones de uso común
- sleep:
- 3 g, 1 hour before bed
Límite superior: Not established; studied up to 9 g/day
Dosificaciones estudiadas en la investigación
| Dosificación | Duración | Efecto | N |
|---|---|---|---|
| Lactobacillus reuteri E9 (dose not specified) | -- | Positive | -- |
| various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa | -- | Positive | 451 |
| None | -- | Neutral | -- |
| Arachis hypogaea L. stems and leaves extract | -- | Positive | -- |
| 15 g/day collagen peptides (glycine-rich) consumed 1 hour before bedtime for 7 nights | 1 weeks | Positive | 13 |
| None | 3 weeks | Positive | -- |
| not applicable | -- | Neutral | 17 |
| None | -- | Mixed | 482730 |
Mejor momento para tomar: 1 hour before bed
Safety & Side Effects
Efectos secundarios reportados
- ⚠ Nausea
- ⚠ Soft stools
- ⚠ Mild drowsiness
Interacciones conocidas
- ● Clozapine — glycine may reduce effectiveness of this antipsychotic
- ● Antihypertensives — potential additive blood pressure lowering
Ingesta máxima tolerable: Not established; studied up to 9 g/day
Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.
Frequently Asked Questions
Does Glycine help with Insomnio?
Based on 36 studies with 483,763 participants, there is strong evidence from multiple clinical trials that Glycine may support Insomnio management. Our evidence grade is A (Strong Evidence).
How much Glycine should I take for Insomnio?
Studies have used various dosages. A commonly studied range is 3 g, 1 hour before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Glycine?
Reported side effects may include Nausea, Soft stools, Mild drowsiness. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Glycine and Insomnio?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 36 peer-reviewed studies with 483,763 total participants. The overall direction of effect is positive.
Related Evidence
Otros ingredientes para Insomnio
Glycine para otras condiciones
References
- [1] Meijia Li et al.. Pharmaceuticals (Basel). 2026. Synergistic Therapeutic Effects of Tetrahydroberberine Combined with Protopanaxadiol on PCPA-Induced Insomnia in Rats: Involvement of the Microbiota-Gut-Brain Axis and Regulation … doi:10.3390/ph19030390 PubMed
- [2] Xiaohan Zhang et al.. J Chem Inf Model. 2025. The Glycine-Rich Region as a Flexible Molecular Glue Promoting hPrP106-145 Aggregation into β-Sheet Structures. doi:10.1021/acs.jcim.5c00785 PubMed
- [3] Kanchan Upreti et al.. Children (Basel). 2025. Effectiveness of Homoeopathic Treatments for Sleep Disorders in Children and Adolescents: A Systematic Review According to the Principles of Evidence-Based … doi:10.3390/children13010045 PubMed
- [4] Yongcheng Jiang et al.. Front Biosci (Landmark Ed). 2025. Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA. doi:10.31083/FBL39587 PubMed
- [5] Yin Wang et al.. J Pharm Anal. 2025. Time-specific study on the efficacy of stems and leaves of Arachis hypogaea L. targeting glycine/serine metabolism for insomnia treatment. doi:10.1016/j.jpha.2025.101288 PubMed
- [6] Craig Thomas et al.. Eur J Nutr. 2024. Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active males with sleep complaints. doi:10.1007/s00394-023-03267-w PubMed
- [7] Shujun Wang et al.. J Ethnopharmacol. 2024. Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice. doi:10.1016/j.jep.2023.116973 PubMed
- [8] Mengya Chen et al.. Hum Genet. 2023. Investigating the shared genetic architecture and causal relationship between pain and neuropsychiatric disorders. doi:10.1007/s00439-022-02507-z PubMed
- [9] Irem Erkent et al.. Neurol Sci. 2023. Sleep disorders and polysomnography findings in patients with autoimmune encephalitis. doi:10.1007/s10072-022-06513-x PubMed
- [10] Minsook Ye et al.. Int J Mol Sci. 2023. Sedative-Hypnotic Effects of Glycine max Merr. Extract and Its Active Ingredient Genistein on Electric-Shock-Induced Sleep Disturbances in Rats. doi:10.3390/ijms24087043 PubMed
- [11] Samaneh Takhti et al.. J Biomol Struct Dyn. 2023. New hybrids based on benzimidazole and diazepine moieties: design, synthesis, characterization, molecular docking studies and their in vitro interactions with … doi:10.1080/07391102.2022.2136246 PubMed
- [12] Yan-Pei Hou et al.. J Formos Med Assoc. 2022. Roxadustat treatment for anemia in peritoneal dialysis patients: A randomized controlled trial. doi:10.1016/j.jfma.2021.06.004 PubMed
- [13] Dominique Endres et al.. Brain Sci. 2020. Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies. doi:10.3390/brainsci10060399 PubMed
- [14] Ying Wang et al.. Biomed Res Int. 2019. Metabonomics Study of Ginseng Glycoproteins on Improving Sleep Quality in Mice. doi:10.1155/2019/2561828 PubMed
- [15] Jorge J Castillo et al.. Clin Cancer Res. 2018. Prospective Clinical Trial of Ixazomib, Dexamethasone, and Rituximab as Primary Therapy in Waldenström Macroglobulinemia. doi:10.1158/1078-0432.CCR-18-0152 PubMed
- [16] Shyamala C Navada et al.. Leuk Res. 2018. A phase 1/2 study of rigosertib in patients with myelodysplastic syndromes (MDS) and MDS progressed to acute myeloid leukemia. doi:10.1016/j.leukres.2017.11.006 PubMed
- [17] Rahele Kargozar et al.. Electron Physician. 2017. A review of effective herbal medicines in controlling menopausal symptoms. doi:10.19082/5826 PubMed
- [18] Pierre-Hervé Luppi et al.. Sleep Med Rev. 2017. Not a single but multiple populations of GABAergic neurons control sleep. doi:10.1016/j.smrv.2016.03.002 PubMed
- [19] Yoshio Hirayasu et al.. BMC Psychiatry. 2016. A double-blind randomized study assessing safety and efficacy following one-year adjunctive treatment with bitopertin, a glycine reuptake inhibitor, in Japanese … doi:10.1186/s12888-016-0778-9 PubMed
- [20] Matteo Caloro et al.. Addict Behav. 2016. Use of benzylglycinamide by a HIV-seropositive polysubstance user: The changing pattern of novel psychoactive substance use among youths. doi:10.1016/j.addbeh.2016.03.032 PubMed
- [21] Li-Na Chen et al.. Mol Neurobiol. 2016. Proteomic Analyses for the Global S-Nitrosylated Proteins in the Brain Tissues of Different Human Prion Diseases. doi:10.1007/s12035-015-9440-7 PubMed
- [22] Jing-Yang Zhang et al.. Fitoterapia. 2015. Gelsemium analgesia and the spinal glycine receptor/allopregnanolone pathway. doi:10.1016/j.fitote.2014.11.002 PubMed
- [23] Jiapu Zhang et al.. Acta Biochim Biophys Sin (Shanghai). 2013. Molecular dynamics studies on 3D structures of the hydrophobic region PrP(109-136). doi:10.1093/abbs/gmt031 PubMed
- [24] Makoto Bannai et al.. Front Neurol. 2012. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. doi:10.3389/fneur.2012.00061 PubMed
- [25] Makoto Bannai et al.. Psychiatry Clin Neurosci. 2011. Oral administration of glycine increases extracellular serotonin but not dopamine in the prefrontal cortex of rats. doi:10.1111/j.1440-1819.2010.02181.x PubMed
- [26] Vera M Kalscheuer et al.. Hum Mutat. 2009. A balanced chromosomal translocation disrupting ARHGEF9 is associated with epilepsy, anxiety, aggression, and mental retardation. doi:10.1002/humu.20814 PubMed
- [27] David J Morris et al.. Steroids. 2009. Interactions of mineralocorticoids and glucocorticoids in epithelial target tissues revisited. doi:10.1016/j.steroids.2008.10.005 PubMed
- [28] Rajdeep Dasgupta et al.. Curr Drug Deliv. 2009. Investigation of in vitro iontophoresis facilitated transdermal delivery of glycine. doi:10.2174/156720109787846207 PubMed
- [29] Atsushi Takeda et al.. Nutr Neurosci. 2008. Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats. doi:10.1179/147683008X301414 PubMed
- [30] Jing Ye et al.. J Med Case Rep. 2008. Human prion disease with a G114V mutation and epidemiological studies in a Chinese family: a case series. doi:10.1186/1752-1947-2-331 PubMed
- [31] N G Bowery et al.. Br J Pharmacol. 2006. GABA and glycine as neurotransmitters: a brief history. doi:10.1038/sj.bjp.0706443 PubMed
- [32] M Mucci et al.. Minerva Ginecol. 2006. Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. PubMed
- [33] Béatrice Astruc et al.. Br J Clin Pharmacol. 2005. Steady-state pharmacokinetics and pharmacodynamics of CHF3381, a novel antineuropathic pain agent, in healthy subjects. doi:10.1111/j.1365-2125.2005.02338.x PubMed
- [34] Ana Lia Taratuto et al.. Neurology. 2002. Insomnia associated with thalamic involvement in E200K Creutzfeldt-Jakob disease. doi:10.1212/wnl.58.3.362 PubMed
- [35] G S Kelly. Altern Med Rev. 1998. Folates: supplemental forms and therapeutic applications. PubMed
- [36] D E Burdette et al.. Clin Neuropharmacol. 1994. Felbamate pharmacology and use in epilepsy. doi:10.1097/00002826-199410000-00001 PubMed
- [37] T Dyckner et al.. Eur J Clin Pharmacol. 1986. Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial … doi:10.1007/BF00542411 PubMed
Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.