Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active males with sleep complaints.
Craig Thomas,
Ruth N Kingshott,
Kirsty M Allott,
Jonathan C Y Tang,
Rachel Dunn
et al.
RCT
European journal of nutrition
2024
10 citazioni
PubMed
DOI
CC-BY
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Study Design
- Tipo di studio
- randomized controlled trial
- Dimensione del campione
- 13
- Durata
- 1 weeks
- Intervento
- Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active males with sleep complaints. 15 g/day collagen peptides (glycine-rich) consumed 1 hour before bedtime for 7 nights
- Comparatore
- Placebo
- Direzione dell'effetto
- Positive
- Rischio di bias
- Low
Abstract
PURPOSE: The primary aim of this study was to examine whether a glycine-rich collagen peptides (CP) supplement could enhance sleep quality in physically active men with self-reported sleep complaints. METHODS: In a randomized, crossover design, 13 athletic males (age: 24 ± 4 years; training volume; 7 ± 3 h·wk1) with sleep complaints (Athens Insomnia Scale, 9 ± 2) consumed CP (15 g·day1) or a placebo control (CON) 1 h before bedtime for 7 nights. Sleep quality was measured with subjective sleep diaries and actigraphy for 7 nights; polysomnographic sleep and core temperature were recorded on night 7. Cognition, inflammation, and endocrine function were measured on night 7 and the following morning. Subjective sleepiness and fatigue were measured on all 7 nights. The intervention trials were separated by ≥ 7 days and preceded by a 7-night familiarisation trial. RESULTS: Polysomnography showed less awakenings with CP than CON (21.3 ± 9.7 vs. 29.3 ± 13.8 counts, respectively; P = 0.028). The 7-day average for subjective awakenings were less with CP vs. CON (1.3 ± 1.5 vs. 1.9 ± 0.6 counts, respectively; P = 0.023). The proportion of correct responses on the baseline Stroop cognitive test were higher with CP than CON (1.00 ± 0.00 vs. 0.97 ± 0.05 AU, respectively; P = 0.009) the morning after night 7. There were no trial differences in core temperature, endocrine function, inflammation, subjective sleepiness, fatigue and sleep quality, or other measures of cognitive function or sleep (P > 0.05). CONCLUSION: CP supplementation did not influence sleep quantity, latency, or efficiency, but reduced awakenings and improved cognitive function in physically active males with sleep complaints.
Full Text
Figures
Tables
Table 1
| Variable | |
|---|---|
| Age (years) | 24 ± 4 |
| Height (m) | 1.8 ± 0.1 |
| Body mass (kg) | 79.2 ± 12.6 |
| AIS | 9 ± 2 |
| MEQ | 50 ± 8 |
| Exercise training frequency (n/week) | 5 ± 2 |
| Exercise training volume (h/week) | 7 ± 3 |
Table 2
| Variable | Control | CP | P value | Effect size | 95% CI |
|---|---|---|---|---|---|
| Time in bed (min) | 493.4 ± 41.3 | 492.6 ± 48.3 | 0.912 | 0.032 | − 15.1 to 16.7 |
| Total sleep time (min) | 449.2 ± 46.1 | 454.9 ± 49.4 | 0.388 | 0.250 | − 19.6 to 8.26 |
| Sleep latency (min) | 14.2 ± 10.7 | 12.8 ± 9.2 | 0.578 | 0.160 | − 3.85 to 6.57 |
| Sleep efficiency (%) | 91.0 ± 4.2 | 91.9 ± 3.7 | 0.376 | 0.257 | − 2.98 to 1.22 |
| Sleep latency N2 (min) | 18.5 ± 11.6 | 14.9 ± 8.9 | 0.245 | 0.342 | − 2.79 to 9.84 |
| Deep sleep latency (min) | 29.6 ± 14.1 | 26.7 ± 9.4 | 0.418 | 0.235 | − 4.54 to 10.1 |
| REM sleep latency^ (min) | 79.9 ± 26.8 | 76.8 ± 26.4 | 0.450 | 0.258 | − 10.0 to 25.2 |
| Total sleep period^ (min) | 479.1 ± 44.7 | 479.7 ± 55.7 | 1.000 | 0.000 | − 16.5 to 15.0 |
| Sleep stage change (count) | 113.8 ± 42.1 | 100.7 ± 30.8 | 0.188 | 0.391 | − 7.50 to 33.8 |
| Sleep stage change^ (count/hr) | 13.8 ± 4.9 | 12.8 ± 3.3 | 0.477 | 0.242 | − 1.50 to 3.35 |
| Wakening’s^ (count) | 29.3 ± 13.8 | 21.3 ± 9.7 | 0.028* | 0.782 | 1.00 to 16.0 |
| Wakening’s^ (count/hr) | 4.0 ± 1.9 | 2.9 ± 1.2 | 0.028* | 0.782 | 0.15 to 2.00 |
| Wake after sleep onset^ (min) | 30.0 ± 21.1 | 24.4 ± 16.9 | 0.272 | 0.359 | − 4.46 to 16.0 |
| REM stage sleep# (%) | 22.4 ± 3.2 | 21.6 ± 5.7 | 0.624 | 0.140 | − 2.52 to 4.02 |
| N1 stage sleep# (%) | 5.5 ± 2.5 | 4.6 ± 1.8 | 0.109 | 0.486 | − 0.22 to 1.90 |
| N2 stage sleep# (%) | 44.2 ± 5.9 | 45.6 ± 4.3 | 0.262 | 0.329 | − 4.00 to 1.20 |
| N3 stage sleep# (%) | 28.0 ± 5.7 | 28.2 ± 6.4 | 0.833 | 0.042 | − 3.13 to 2.73 |
| Light sleep# (%) | 49.7 ± 6 .9 | 50.2 ± 5.2 | 0.691 | 0.114 | − 3.57 to 2.45 |
| Arousal^ (count) | 62.4 ± 41.8 | 53.4 ± 23.0 | 0.266 | 0.379 | − 4.50 to 21.5 |
| Arousal^ (count/hr) | 8.5 ± 6.0 | 7.4 ± 3.0 | 0.533 | 0.212 | −0.95 to 2.40 |
Table 3
| Variable | Control | Collagen peptides | P value | Effect size | 95% CI |
|---|---|---|---|---|---|
| Time in bed (min) | 488.1 ± 35.3 | 491.1 ± 43.9 | 0.710 | 0.102 | -20.1 to 14.1 |
| Total sleep time (min) | 382.4 ± 35.8 | 384.8 ± 37.1 | 0.654 | 0.123 | -14.1 to 9.20 |
| Sleep latency (min) | 10.9 ± 7.7 | 8.8 ± 5.8 | 0.155 | 0.407 | -0.90 to 5.06 |
| Sleep efficiency (%) | 78.7 ± 7.7 | 78.9 ± 8.4 | 0.894 | 0.036 | -2.62 to 2.31 |
| Wake after sleep onset (min) | 94.8 ± 37.3 | 97.5 ± 44.1 | 0.735 | 0.093 | -17.9 to 13.0 |
| Average wake length (min) | 3.34 ± 1.00 | 3.14 ± 0.83 | 0.423 | 0.223 | -0.35 to 0.78 |
Table 4
| Variable | Control | Collagen peptides |
|---|---|---|
| KSS-AM (AU) | 5.0 ± 0.8 | 4.9 ± 0.8 |
| KSS-MID (AU) | 3.5 ± 0.9 | 3.5 ± 0.7 |
| KSS-PM (AU) | 5.9 ± 0.8 | 5.3 ± 1.0 |
| Fatigue-AM (mm) | 48.2 ± 12.8 | 49.3 ± 12.6 |
| Fatigue-MID (mm) | 63.3 ± 14.9 | 62.3 ± 13.0 |
| Fatigue-PM (mm) | 39.5 ± 8.8 | 43.3 ± 11.3 |
| Sleep quality (AU) | 4.4 ± 0.4 | 4.5 ± 0.5 |
Table 5
| Variable | Control | CP | P value |
|---|---|---|---|
| Simple reaction timeAv (ms) | 0.310; 0.743; 0.424 | ||
| Pre | 306 ± 31 | 313 ± 33 | |
| Post | 319 ± 40 | 317 ± 29 | |
| Simple reaction timeFAST (ms) | 0.633; 0.435; 0.669 | ||
| Pre | 260 ± 43 | 263 ± 68 | |
| Post | 257 ± 39 | 247 ± 73 | |
| Choice reaction timeAV (ms) | 0.030; 0.138; 0.164 | ||
| Pre | 397 ± 24 | 414 ± 28 | |
| Post | 389 ± 33 | 392 ± 26 | |
| Choice reaction timeFAST (ms) | < 0.001; 0.819; 0.770 | ||
| Pre | 333 ± 14 | 335 ± 20 | |
| Post | 320 ± 23 | 320 ± 26 | |
| Digit span (AU) | 0.670; 0.094; 0.206 | ||
| Pre | 8 ± 2 | 8 ± 1 | |
| Post | 8 ± 1 | 8 ± 1 | |
| Stroop test BLAV (ms) | 0.152; 0.510; 0.803 | ||
| Pre | 667 ± 86 | 682 ± 105 | |
| Post | 642 ± 96 | 652 ± 82 | |
| Stroop test IFAV (ms) | 0.232; 0.621; 0.752 | ||
| Pre | 900 ± 171 | 887 ± 200 | |
| Post | 859 ± 179 | 832 ± 196 | |
| Stroop test BLCR (AU)* | 0.720; 0.285; 0.007 | ||
| Pre | 0.99 ± 0.02 | 0.98 ± 0.03 | |
| Post | 0.97 ± 0.05 | 1.00 ± 0.00 | |
| Stroop test IFCR (AU) | 0.649; 1.000; 0.789 | ||
| Pre | 0.94 ± 0.04 | 0.95 ± 0.07 | |
| Post | 0.95 ± 0.04 | 0.95 ± 0.09 |
Table 6
| Variable | Control | CP | P value |
|---|---|---|---|
| IL-6 (pg/ml) | |||
| Pre | 1.32 ± 2.11 | 0.67 ± 0.28 | 0.935; 0.438; 0.127 |
| Post | 0.95 ± 0.76 | 1.09 ± 1.29 | |
| Cortisol (nmol/L) | |||
| Pre | 220.8 ± 70.9 | 245.6 ± 81.0 | < 0.001; 0.310; 0.771 |
| Post | 353.6 ± 79.5 | 370.5 ± 96.4 | |
| Hs-CRP (nmol/L) | |||
| Pre | 4.11 ± 3.63 | 3.89 ± 2.04 | 0.471; 0.666; 0.554 |
| Post | 3.61 ± 3.29 | 3.29 ± 2.04 | |
| Normetanephrine (nmol/L per mmol/L of creatinine) | |||
| Pre | 8.63 ± 2.24 | 8.72 ± 2.95 | 0.974; 0.528; 0.445 |
| Post | 8.92 ± 2.68 | 8.55 ± 2.65 |
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