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Ashwagandha für Insomnie

A

Basierend auf 30 Studien (4 meta-analyses, 5 RCTs) mit 1,810 Teilnehmern insgesamt. 29/30 Studien zeigen positive Effekte.

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A

Fazit

Ashwagandha is one of the most well-researched herbal supplements for insomnia, with strong and consistent evidence that it may support better sleep quality.

  • 29 out of 30 studies show positive effects, including 5 RCTs and 4 meta-analyses
  • Grade A evidence — the highest level of support among sleep supplements
  • Works through multiple pathways including GABA receptors, histamine modulation, and stress reduction
  • Both healthy adults and people with insomnia have shown improvements in clinical trials

Key Study Findings

Review
The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …
Dose: None vs.: None Outcome: None Wirkung: None None

Population: narrative review of ashwagandha clinical trials and basic research (1994-present)

preclinical animal/in vitro study
Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …
Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL vs.: Placebo Wirkung: None None
RCT n=90 12 weeks Double-blind
A New Ashwagandha Formulation (Zenroot™) Alleviates Stress and Anxiety Symptoms While Improving Mood and Sleep …
Dose: 125 mg Zenroot (Ashwagandha with 1.5% total withanolides) daily vs.: Placebo Wirkung: None < 0.05
Meta-analysis n=713 8 weeks Double-blind
The effect of Withania somnifera (Ashwagandha) on mental health symptoms in individuals with mental disorders: …
Dose: 600 mg/day (median) vs.: Placebo Wirkung: SMD=-1.13 (anxiety, outlier-corrected); SMD=-1.28 (depression); SMD=-0.95 (stress); SMD=-1.35 (sleep None
Case Report n=1
Unmasking Potential Withdrawal Effects of Ashwagandha: A Case Report and Review.
Dose: Ashwagandha extract 600 mg/day (prior to discontinuation) vs.: Placebo Wirkung: None None

Key Statistics

31

Studien

1810

Teilnehmer

Positive

A

Bewertung

Referenced Papers

Naunyn-Schmiedeberg's archives of … 2025 4 Zitierungen
International journal of … 2023 43 Zitierungen
Child and adolescent … 2023 5 Zitierungen
Journal of ethnopharmacology 2020 85 Zitierungen
Biological & pharmaceutical … 2014 110 Zitierungen

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

sleep:
300-600 mg KSM-66 or Sensoril, before bed

Obergrenze: Not established; studied up to 1,200 mg/day

In der Forschung untersuchte Dosierungen

Dosierung Dauer Wirkung N
None -- Positive --
None -- Positive --
60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL -- Positive --
125 mg Zenroot (Ashwagandha with 1.5% total withanolides) daily 12 weeks Positive 90
600 mg/day (median) 8 weeks Positive 713
Ashwagandha extract 600 mg/day (prior to discontinuation) -- Negative 1
ashwagandha 250 mg/day, ashwagandha 250 mg + tryptophan 175 mg/day, or ashwagandha 600 mg/day (250 m 13 weeks Positive 52
varies across included RCTs -- Positive 254

Beste Einnahmezeit: 1-2 hours before bed

Safety & Side Effects

Gemeldete Nebenwirkungen

  • Drowsiness
  • GI upset
  • Diarrhea
  • Headache

Bekannte Wechselwirkungen

  • Thyroid medications — ashwagandha may increase thyroid hormone levels
  • Immunosuppressants — ashwagandha may stimulate immune activity
  • Sedatives — potential additive drowsiness
  • Blood sugar medications — may lower blood glucose

Tolerierbare Höchstaufnahmemenge: Not established; studied up to 1,200 mg/day

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does Ashwagandha help with Insomnie?
Based on 31 studies with 1,810 participants, there is strong evidence from multiple clinical trials that Ashwagandha may support Insomnie management. Our evidence grade is A (Strong Evidence).
How much Ashwagandha should I take for Insomnie?
Studies have used various dosages. A commonly studied range is 300-600 mg KSM-66 or Sensoril, before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Ashwagandha?
Reported side effects may include Drowsiness, GI upset, Diarrhea, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Ashwagandha and Insomnie?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 31 peer-reviewed studies with 1,810 total participants. The overall direction of effect is positive.

Related Evidence

FDA-Haftungsausschluss: Diese Aussagen wurden nicht von der Food and Drug Administration bewertet. Die Produkte und Informationen auf dieser Website sind nicht dazu bestimmt, Krankheiten zu diagnostizieren, zu behandeln, zu heilen oder zu verhindern. Die dargestellten Evidenzbewertungen basieren auf unserer Analyse veröffentlichter begutachteter Forschung und stellen keine medizinische Beratung dar. Konsultieren Sie immer Ihren Arzt, bevor Sie mit der Einnahme von Nahrungsergänzungsmitteln beginnen.