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Ashwagandha для Бессонница

A

На основе 30 исследований (4 meta-analyses, 5 RCTs) с участием 1,810 участников. 29/30 исследований показывают положительные эффекты.

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A

Итог

Ashwagandha is one of the most well-researched herbal supplements for insomnia, with strong and consistent evidence that it may support better sleep quality.

  • 29 out of 30 studies show positive effects, including 5 RCTs and 4 meta-analyses
  • Grade A evidence — the highest level of support among sleep supplements
  • Works through multiple pathways including GABA receptors, histamine modulation, and stress reduction
  • Both healthy adults and people with insomnia have shown improvements in clinical trials

Key Study Findings

Review
The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …
Dose: None или: None Outcome: None Эффект: None None

Популяция: narrative review of ashwagandha clinical trials and basic research (1994-present)

preclinical animal/in vitro study
Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …
Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL или: Placebo Эффект: None None
RCT n=90 12 weeks Double-blind
A New Ashwagandha Formulation (Zenroot™) Alleviates Stress and Anxiety Symptoms While Improving Mood and Sleep …
Dose: 125 mg Zenroot (Ashwagandha with 1.5% total withanolides) daily или: Placebo Эффект: None < 0.05
Meta-analysis n=713 8 weeks Double-blind
The effect of Withania somnifera (Ashwagandha) on mental health symptoms in individuals with mental disorders: …
Dose: 600 mg/day (median) или: Placebo Эффект: SMD=-1.13 (anxiety, outlier-corrected); SMD=-1.28 (depression); SMD=-0.95 (stress); SMD=-1.35 (sleep None
Case Report n=1
Unmasking Potential Withdrawal Effects of Ashwagandha: A Case Report and Review.
Dose: Ashwagandha extract 600 mg/day (prior to discontinuation) или: Placebo Эффект: None None

Key Statistics

31

Исследования

1810

Участники

Positive

A

Оценка

Referenced Papers

Naunyn-Schmiedeberg's archives of … 2025 4 цитирований
International journal of … 2023 43 цитирований
Child and adolescent … 2023 5 цитирований
Pharmacological research 2022 51 цитирований
Planta medica 2021 41 цитирований
Journal of ethnopharmacology 2020 85 цитирований
Phytotherapy research : … 2018 95 цитирований
Biological & pharmaceutical … 2014 110 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

sleep:
300-600 mg KSM-66 or Sensoril, before bed

Верхний предел: Not established; studied up to 1,200 mg/day

Дозировки, изученные в исследованиях

Дозировка Длительность Эффект N
None -- Positive --
None -- Positive --
60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL -- Positive --
125 mg Zenroot (Ashwagandha with 1.5% total withanolides) daily 12 weeks Positive 90
600 mg/day (median) 8 weeks Positive 713
Ashwagandha extract 600 mg/day (prior to discontinuation) -- Negative 1
ashwagandha 250 mg/day, ashwagandha 250 mg + tryptophan 175 mg/day, or ashwagandha 600 mg/day (250 m 13 weeks Positive 52
varies across included RCTs -- Positive 254

Лучшее время приёма: 1-2 hours before bed

Safety & Side Effects

Зарегистрированные побочные эффекты

  • Drowsiness
  • GI upset
  • Diarrhea
  • Headache

Известные взаимодействия

  • Thyroid medications — ashwagandha may increase thyroid hormone levels
  • Immunosuppressants — ashwagandha may stimulate immune activity
  • Sedatives — potential additive drowsiness
  • Blood sugar medications — may lower blood glucose

Допустимый верхний уровень потребления: Not established; studied up to 1,200 mg/day

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Ashwagandha help with Бессонница?
Based on 31 studies with 1,810 participants, there is strong evidence from multiple clinical trials that Ashwagandha may support Бессонница management. Our evidence grade is A (Strong Evidence).
How much Ashwagandha should I take for Бессонница?
Studies have used various dosages. A commonly studied range is 300-600 mg KSM-66 or Sensoril, before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Ashwagandha?
Reported side effects may include Drowsiness, GI upset, Diarrhea, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Ashwagandha and Бессонница?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 31 peer-reviewed studies with 1,810 total participants. The overall direction of effect is positive.

Related Evidence

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.