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Ashwagandha için Uykusuzluk

A

30 çalışmaya (4 meta-analyses, 5 RCTs), toplam 1,810 katılımcıyla dayanmaktadır. 29/30 çalışma olumlu etkiler göstermektedir.

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A

Sonuç

Ashwagandha is one of the most well-researched herbal supplements for insomnia, with strong and consistent evidence that it may support better sleep quality.

  • 29 out of 30 studies show positive effects, including 5 RCTs and 4 meta-analyses
  • Grade A evidence — the highest level of support among sleep supplements
  • Works through multiple pathways including GABA receptors, histamine modulation, and stress reduction
  • Both healthy adults and people with insomnia have shown improvements in clinical trials

Key Study Findings

Review
The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …
Dose: None vs: None Outcome: None Etki: None None

Popülasyon: narrative review of ashwagandha clinical trials and basic research (1994-present)

preclinical animal/in vitro study
Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …
Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL vs: Placebo Etki: None None
RCT n=90 12 weeks Double-blind
A New Ashwagandha Formulation (Zenroot™) Alleviates Stress and Anxiety Symptoms While Improving Mood and Sleep …
Dose: 125 mg Zenroot (Ashwagandha with 1.5% total withanolides) daily vs: Placebo Etki: None < 0.05
Meta-analysis n=713 8 weeks Double-blind
The effect of Withania somnifera (Ashwagandha) on mental health symptoms in individuals with mental disorders: …
Dose: 600 mg/day (median) vs: Placebo Etki: SMD=-1.13 (anxiety, outlier-corrected); SMD=-1.28 (depression); SMD=-0.95 (stress); SMD=-1.35 (sleep None
Case Report n=1
Unmasking Potential Withdrawal Effects of Ashwagandha: A Case Report and Review.
Dose: Ashwagandha extract 600 mg/day (prior to discontinuation) vs: Placebo Etki: None None

Key Statistics

31

Çalışmalar

1810

Katılımcılar

Positive

A

Derece

Referenced Papers

International journal of … 2023 43 atıf
Journal of ethnopharmacology 2020 85 atıf

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Yaygın Kullanılan Dozajlar

sleep:
300-600 mg KSM-66 or Sensoril, before bed

Üst sınır: Not established; studied up to 1,200 mg/day

Araştırmalarda İncelenen Dozajlar

Dozaj Süre Etki N
None -- Positive --
None -- Positive --
60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL -- Positive --
125 mg Zenroot (Ashwagandha with 1.5% total withanolides) daily 12 weeks Positive 90
600 mg/day (median) 8 weeks Positive 713
Ashwagandha extract 600 mg/day (prior to discontinuation) -- Negative 1
ashwagandha 250 mg/day, ashwagandha 250 mg + tryptophan 175 mg/day, or ashwagandha 600 mg/day (250 m 13 weeks Positive 52
varies across included RCTs -- Positive 254

En iyi alım zamanı: 1-2 hours before bed

Safety & Side Effects

Bildirilen Yan Etkiler

  • Drowsiness
  • GI upset
  • Diarrhea
  • Headache

Bilinen Etkileşimler

  • Thyroid medications — ashwagandha may increase thyroid hormone levels
  • Immunosuppressants — ashwagandha may stimulate immune activity
  • Sedatives — potential additive drowsiness
  • Blood sugar medications — may lower blood glucose

Tolere edilebilir üst alım: Not established; studied up to 1,200 mg/day

Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.

Frequently Asked Questions

Does Ashwagandha help with Uykusuzluk?
Based on 31 studies with 1,810 participants, there is strong evidence from multiple clinical trials that Ashwagandha may support Uykusuzluk management. Our evidence grade is A (Strong Evidence).
How much Ashwagandha should I take for Uykusuzluk?
Studies have used various dosages. A commonly studied range is 300-600 mg KSM-66 or Sensoril, before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Ashwagandha?
Reported side effects may include Drowsiness, GI upset, Diarrhea, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Ashwagandha and Uykusuzluk?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 31 peer-reviewed studies with 1,810 total participants. The overall direction of effect is positive.

Related Evidence

FDA Sorumluluk Reddi: Bu ifadeler Gıda ve İlaç Dairesi (FDA) tarafından değerlendirilmemiştir. Bu web sitesindeki ürünler ve bilgiler herhangi bir hastalığı teşhis etmek, tedavi etmek, iyileştirmek veya önlemek amacıyla tasarlanmamıştır. Sunulan kanıt dereceleri, yayımlanmış hakemli araştırmalarımızın analizine dayanmaktadır ve tıbbi tavsiye niteliği taşımamaktadır. Herhangi bir takviye rejimine başlamadan önce her zaman sağlık uzmanınıza danışın.