Hoa Lạc Tiên cho Mất Ngủ

Dựa trên 20 nghiên cứu (5 meta-analyses, 1 RCT) với 2,820 người tham gia. 15/20 nghiên cứu cho thấy tác động tích cực.

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Kết luận

Passionflower is supported by good evidence as an herbal supplement that may help improve overall sleep quality for people with insomnia.

20 studies including 5 meta-analyses support passionflower for insomnia
75% of studies report positive effects on sleep
Research suggests it works through GABA pathways to promote relaxation
Generally considered safe and well-tolerated based on available evidence

Key Study Findings

Review n=51

Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials.

Dose: None so với: Placebo Hiệu quả: 41/51 studies demonstrated positive effects on insomnia symptoms None

Review

The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, …

Dose: None so với: Placebo Hiệu quả: None None

Review

Integrative sleep management: from molecular pathways to conventional and herbal treatments.

Dose: None so với: Placebo Hiệu quả: None None

review

Plants with Potential Importance in Supporting the Treatment of Depression: Current Trends, and Research.

Dose: varies by plant and study so với: Placebo Hiệu quả: promising results for saffron, turmeric, ginkgo, St. John's wort, passionflower None

Meta-Analysis

Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.

Dose: Various medicinal herbs: Silexan, Kava, Ginkgo biloba, Withania somnifera, Galphimia glauca, Passion so với: Placebo Hiệu quả: Silexan MD -3.84 (95% CrI -6.31 to -1.34); Kava MD -2.46 (95% CrI -4.47 to -0.32); Ginkgo biloba MD None

Review

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review.

Dose: None so với: Placebo Hiệu quả: None None

Key Statistics

Nghiên cứu

2820

Người tham gia

↑

Positive

Xếp hạng

Referenced Papers

Efficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks. Review

Pharmaceuticals (Basel, Switzerland) 2026

Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials. Review

Sleep medicine 2025 4 trích dẫn

Integrative sleep management: from molecular pathways to conventional and herbal treatments. Review

Naunyn-Schmiedeberg's archives of … 2025 4 trích dẫn

The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs. Review

Molecules (Basel, Switzerland) 2025 2 trích dẫn

Plants with Potential Importance in Supporting the Treatment of Depression: Current Trends, and Research. Review

Pharmaceuticals (Basel, Switzerland) 2024 9 trích dẫn

Edible Herbal Medicines as an Alternative to Common Medication for Sleep Disorders: A Review Article. Review

Current neuropharmacology 2024 9 trích dẫn

Randomized, Double-Blind, Placebo-Controlled, Clinical Study of Passiflora incarnata in Participants With Stress and Sleep Problems. Other

Cureus 2024

Hydroalcoholic extract of Passiflora incarnata improves the autistic-like behavior and neuronal damage in a valproic acid-induced rat model of autism. Other

Journal of traditional … 2023 24 trích dẫn

Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre-clinical studies published from 2010 to … Systematic Review

Phytotherapy research : … 2023 14 trích dẫn

Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis. Meta-Analysis

Pharmacological research 2022 51 trích dẫn

Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep. Systematic Review

Nutrients 2021 85 trích dẫn

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review. Review

Planta medica 2021 41 trích dẫn

Use of Plant-Derived Natural Products in Sleep Disturbances. Review

Advances in experimental … 2021 7 trích dẫn

Sintocalmy, a Passiflora incarnata Based Herbal, Attenuates Morphine Withdrawal in Mice. Other

Neurochemical research 2021 4 trích dẫn

[Literature research of Passiflora incarnata and discussion of its traditional Chinese medicine properties]. Other

Zhongguo Zhong yao … 2021 3 trích dẫn

Passiflora incarnata in Neuropsychiatric Disorders-A Systematic Review. Systematic Review

Nutrients 2020 56 trích dẫn

Endophytic fungi from Passiflora incarnata: an antioxidant compound source. Other

Archives of microbiology 2020 43 trích dẫn

Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder: a double-blind randomized placebo-controlled study. RCT

International clinical psychopharmacology 2020 20 trích dẫn

Sleep-inducing effect of Passiflora incarnata L. extract by single and repeated oral administration in rodent animals. Other

Food science & … 2020 12 trích dẫn

Improvement in neurogenesis and memory function by administration of Passiflora incarnata L. extract applied to sleep disorder in rodent models. Other

Journal of chemical … 2019 34 trích dẫn

A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. Other

Complementary therapies in … 2019 26 trích dẫn

Chronic oral administration of Passiflora incarnata extract has no abnormal effects on metabolic and behavioral parameters in mice, except to … Other

Laboratory animal research 2019 5 trích dẫn

GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Systematic Review

Phytotherapy research : … 2018 95 trích dẫn

A review of effective herbal medicines in controlling menopausal symptoms. Review

Electronic physician 2017 102 trích dẫn

Role Identification of Passiflora Incarnata Linnaeus: A Mini Review. Review

Journal of menopausal … 2017 40 trích dẫn

Effect of a medicinal plant (Passiflora incarnata L) on sleep. Other

Sleep science (Sao … 2017 32 trích dẫn

Standardized Passiflora incarnata L. Extract Reverts the Analgesia Induced by Alcohol Withdrawal in Rats. Other

Phytotherapy research : … 2017 12 trích dẫn

Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial. RCT

Indian journal of … 2013

Passiflora incarnata L.: ethnopharmacology, clinical application, safety and evaluation of clinical trials. Review

Journal of ethnopharmacology 2013

Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L. Other

Phytotherapy research : … 2011

Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. Systematic Review

Nutrition journal 2010 187 trích dẫn

Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. Review

Medical science monitor … 2009 85 trích dẫn

Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors. Other

BMC complementary and … 2007

Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. Review

Journal of psychopharmacology … 2005 176 trích dẫn

Management of insomnia: a place for traditional herbal remedies. Other

Prescrire international 2005 2 trích dẫn

Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence. Review

Journal of clinical … 2005

Safety and efficacy of herbal sedatives in cancer care. Review

Integrative cancer therapies 2004 59 trích dẫn

Drug/substance reversal effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn.--a brief perspective. Review

Addiction biology 2003

Attenuation of benzodiazepine dependence in mice by a tri-substituted benzoflavone moiety of Passiflora incarnata Linneaus: a non-habit forming anxiolytic. Other

Journal of pharmacy … 2003

Anxiety, depression, and insomnia. Review

Primary care 2002 43 trích dẫn

Anti-anxiety studies on extracts of Passiflora incarnata Linneaus. Other

Journal of ethnopharmacology 2001

[Nature medicine as intoxicant]. Case Report

Tidsskrift for den … 1997

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

sleep:: 250-500 mg extract or 1-2 cups tea, before bed

Giới hạn trên: Not established

Liều lượng đã nghiên cứu

Liều lượng	Thời gian	Hiệu quả	N
None	--	Positive	51
None	--	Positive	--
None	--	Positive	--
varies by plant and study	--	Positive	--
Various medicinal herbs: Silexan, Kava, Ginkgo biloba, Withania somnifera, Galphimia glauca, Passion	--	Positive	--
None	--	Positive	--
varies by product and study	--	Mixed	--
Various Passiflora incarnata preparations (doses not specified in abstract)	--	Positive	--

Thời điểm dùng tốt nhất: 30-60 minutes before bed

Safety & Side Effects

Tác dụng phụ đã được báo cáo

⚠ Drowsiness
⚠ Dizziness
⚠ Confusion at high doses
⚠ Nausea

Tương tác đã biết

● Sedatives and benzodiazepines — additive CNS depression
● Blood thinners — passionflower may increase bleeding risk
● MAOIs — passionflower contains harmala alkaloids

Mức hấp thụ tối đa cho phép: Not established

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Hoa Lạc Tiên help with Mất Ngủ?

Based on 20 studies with 2,820 participants, there is strong evidence from multiple clinical trials that Hoa Lạc Tiên may support Mất Ngủ management. Our evidence grade is A (Strong Evidence).

How much Hoa Lạc Tiên should I take for Mất Ngủ?

Studies have used various dosages. A commonly studied range is 250-500 mg extract or 1-2 cups tea, before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Hoa Lạc Tiên?

Reported side effects may include Drowsiness, Dizziness, Confusion at high doses, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Hoa Lạc Tiên and Mất Ngủ?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 20 peer-reviewed studies with 2,820 total participants. The overall direction of effect is positive.

Related Evidence

Các thành phần khác cho Mất Ngủ

Melatonin A Rễ Valerian A CBD A Axit Béo Omega-3 A Tryptophan A Vitamin D A

Hoa Lạc Tiên cho các tình trạng khác

Vấn Đề Giấc Ngủ Do Lo Âu A

Đánh giá nhanh

Dựa trên 20 nghiên cứu (5 meta-analyses, 1 RCT) với 2,820 người tham gia. 15/20 nghiên cứu cho thấy tác động tích cực.

Evidence Strength92%

High confidence

Phân tích nghiên cứu

RCT (2)Meta (1)Other (17)

So sánh lựa chọn thay thế

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Xem tất cả thành phần cho Mất Ngủ

Tìm hiểu thêm

Tuyên bố miễn trừ FDA: Các tuyên bố này chưa được Cục Quản lý Thực phẩm và Dược phẩm (FDA) đánh giá. Các sản phẩm và thông tin trên trang web này không nhằm mục đích chẩn đoán, điều trị, chữa bệnh hoặc phòng ngừa bất kỳ bệnh nào. Xếp hạng bằng chứng được trình bày dựa trên phân tích của chúng tôi về nghiên cứu đã bình duyệt được công bố và không cấu thành tư vấn y khoa. Luôn tham khảo ý kiến chuyên gia y tế trước khi bắt đầu bất kỳ chế độ thực phẩm chức năng nào.