시계꽃 관련 불면증

총 2,820명의 참여자를 대상으로 한 20건의 연구(메타분석 5건, RCT 1건)에 근거합니다. 20건 중 15건의 연구에서 긍정적인 효과가 나타났습니다.

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결론

Passionflower is supported by good evidence as an herbal supplement that may help improve overall sleep quality for people with insomnia.

20 studies including 5 meta-analyses support passionflower for insomnia
75% of studies report positive effects on sleep
Research suggests it works through GABA pathways to promote relaxation
Generally considered safe and well-tolerated based on available evidence

Key Study Findings

Review n=51

Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials.

Dose: None vs: Placebo 효과: 41/51 studies demonstrated positive effects on insomnia symptoms None

Review

The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, …

Dose: None vs: Placebo 효과: None None

Review

Integrative sleep management: from molecular pathways to conventional and herbal treatments.

Dose: None vs: Placebo 효과: None None

review

Plants with Potential Importance in Supporting the Treatment of Depression: Current Trends, and Research.

Dose: varies by plant and study vs: Placebo 효과: promising results for saffron, turmeric, ginkgo, St. John's wort, passionflower None

Meta-Analysis

Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.

Dose: Various medicinal herbs: Silexan, Kava, Ginkgo biloba, Withania somnifera, Galphimia glauca, Passion vs: Placebo 효과: Silexan MD -3.84 (95% CrI -6.31 to -1.34); Kava MD -2.46 (95% CrI -4.47 to -0.32); Ginkgo biloba MD None

Review

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review.

Dose: None vs: Placebo 효과: None None

Key Statistics

연구

2820

참여자

↑

Positive

등급

Referenced Papers

Efficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks. Review

Pharmaceuticals (Basel, Switzerland) 2026

Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials. Review

Sleep medicine 2025 4 인용

Integrative sleep management: from molecular pathways to conventional and herbal treatments. Review

Naunyn-Schmiedeberg's archives of … 2025 4 인용

The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs. Review

Molecules (Basel, Switzerland) 2025 2 인용

Plants with Potential Importance in Supporting the Treatment of Depression: Current Trends, and Research. Review

Pharmaceuticals (Basel, Switzerland) 2024 9 인용

Edible Herbal Medicines as an Alternative to Common Medication for Sleep Disorders: A Review Article. Review

Current neuropharmacology 2024 9 인용

Randomized, Double-Blind, Placebo-Controlled, Clinical Study of Passiflora incarnata in Participants With Stress and Sleep Problems. Other

Cureus 2024

Hydroalcoholic extract of Passiflora incarnata improves the autistic-like behavior and neuronal damage in a valproic acid-induced rat model of autism. Other

Journal of traditional … 2023 24 인용

Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre-clinical studies published from 2010 to … Systematic Review

Phytotherapy research : … 2023 14 인용

Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis. Meta-Analysis

Pharmacological research 2022 51 인용

Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep. Systematic Review

Nutrients 2021 85 인용

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review. Review

Planta medica 2021 41 인용

Use of Plant-Derived Natural Products in Sleep Disturbances. Review

Advances in experimental … 2021 7 인용

Sintocalmy, a Passiflora incarnata Based Herbal, Attenuates Morphine Withdrawal in Mice. Other

Neurochemical research 2021 4 인용

[Literature research of Passiflora incarnata and discussion of its traditional Chinese medicine properties]. Other

Zhongguo Zhong yao … 2021 3 인용

Passiflora incarnata in Neuropsychiatric Disorders-A Systematic Review. Systematic Review

Nutrients 2020 56 인용

Endophytic fungi from Passiflora incarnata: an antioxidant compound source. Other

Archives of microbiology 2020 43 인용

Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder: a double-blind randomized placebo-controlled study. RCT

International clinical psychopharmacology 2020 20 인용

Sleep-inducing effect of Passiflora incarnata L. extract by single and repeated oral administration in rodent animals. Other

Food science & … 2020 12 인용

Improvement in neurogenesis and memory function by administration of Passiflora incarnata L. extract applied to sleep disorder in rodent models. Other

Journal of chemical … 2019 34 인용

A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. Other

Complementary therapies in … 2019 26 인용

Chronic oral administration of Passiflora incarnata extract has no abnormal effects on metabolic and behavioral parameters in mice, except to … Other

Laboratory animal research 2019 5 인용

GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Systematic Review

Phytotherapy research : … 2018 95 인용

A review of effective herbal medicines in controlling menopausal symptoms. Review

Electronic physician 2017 102 인용

Role Identification of Passiflora Incarnata Linnaeus: A Mini Review. Review

Journal of menopausal … 2017 40 인용

Effect of a medicinal plant (Passiflora incarnata L) on sleep. Other

Sleep science (Sao … 2017 32 인용

Standardized Passiflora incarnata L. Extract Reverts the Analgesia Induced by Alcohol Withdrawal in Rats. Other

Phytotherapy research : … 2017 12 인용

Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial. RCT

Indian journal of … 2013

Passiflora incarnata L.: ethnopharmacology, clinical application, safety and evaluation of clinical trials. Review

Journal of ethnopharmacology 2013

Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L. Other

Phytotherapy research : … 2011

Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. Systematic Review

Nutrition journal 2010 187 인용

Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. Review

Medical science monitor … 2009 85 인용

Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors. Other

BMC complementary and … 2007

Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. Review

Journal of psychopharmacology … 2005 176 인용

Management of insomnia: a place for traditional herbal remedies. Other

Prescrire international 2005 2 인용

Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence. Review

Journal of clinical … 2005

Safety and efficacy of herbal sedatives in cancer care. Review

Integrative cancer therapies 2004 59 인용

Drug/substance reversal effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn.--a brief perspective. Review

Addiction biology 2003

Attenuation of benzodiazepine dependence in mice by a tri-substituted benzoflavone moiety of Passiflora incarnata Linneaus: a non-habit forming anxiolytic. Other

Journal of pharmacy … 2003

Anxiety, depression, and insomnia. Review

Primary care 2002 43 인용

Anti-anxiety studies on extracts of Passiflora incarnata Linneaus. Other

Journal of ethnopharmacology 2001

[Nature medicine as intoxicant]. Case Report

Tidsskrift for den … 1997

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

일반적으로 사용되는 용량

sleep:: 250-500 mg extract or 1-2 cups tea, before bed

상한량: Not established

연구에서 사용된 용량

용량	기간	효과	N
None	--	Positive	51
None	--	Positive	--
None	--	Positive	--
varies by plant and study	--	Positive	--
Various medicinal herbs: Silexan, Kava, Ginkgo biloba, Withania somnifera, Galphimia glauca, Passion	--	Positive	--
None	--	Positive	--
varies by product and study	--	Mixed	--
Various Passiflora incarnata preparations (doses not specified in abstract)	--	Positive	--

권장 복용 시간: 30-60 minutes before bed

Safety & Side Effects

보고된 부작용

⚠ Drowsiness
⚠ Dizziness
⚠ Confusion at high doses
⚠ Nausea

알려진 상호작용

● Sedatives and benzodiazepines — additive CNS depression
● Blood thinners — passionflower may increase bleeding risk
● MAOIs — passionflower contains harmala alkaloids

일일 최대 섭취 허용량: Not established

건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.

Frequently Asked Questions

Does 시계꽃 help with 불면증?

Based on 20 studies with 2,820 participants, there is strong evidence from multiple clinical trials that 시계꽃 may support 불면증 management. Our evidence grade is A (Strong Evidence).

How much 시계꽃 should I take for 불면증?

Studies have used various dosages. A commonly studied range is 250-500 mg extract or 1-2 cups tea, before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of 시계꽃?

Reported side effects may include Drowsiness, Dizziness, Confusion at high doses, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for 시계꽃 and 불면증?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 20 peer-reviewed studies with 2,820 total participants. The overall direction of effect is positive.

Related Evidence

시계꽃 다른 건강 상태에 대한 근거

불안 관련 수면 문제 A

한눈에 보기

총 2,820명의 참여자를 대상으로 한 20건의 연구(메타분석 5건, RCT 1건)에 근거합니다. 20건 중 15건의 연구에서 긍정적인 효과가 나타났습니다.

Evidence Strength92%

High confidence

연구 분석

RCT (2)Meta (1)Other (17)

대안 비교

이 건강 상태에 대한 다른 성분의 비교 결과를 확인하세요.

모든 성분 보기: 불면증

자세히 알아보기

FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.

시계꽃 관련 불면증

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결론

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

일반적으로 사용되는 용량

연구에서 사용된 용량

Safety & Side Effects

보고된 부작용

알려진 상호작용

Frequently Asked Questions

Related Evidence

관련 다른 성분: 불면증

시계꽃 다른 건강 상태에 대한 근거