パッションフラワー：不眠症

合計2,820名の参加者を対象とした20件の研究（メタアナリシス5件、RCT 1件を含む）に基づく。20件中15件の研究で肯定的な効果が示されている。

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結論

Passionflower is supported by good evidence as an herbal supplement that may help improve overall sleep quality for people with insomnia.

20 studies including 5 meta-analyses support passionflower for insomnia
75% of studies report positive effects on sleep
Research suggests it works through GABA pathways to promote relaxation
Generally considered safe and well-tolerated based on available evidence

Key Study Findings

Review n=51

Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials.

Dose: None vs: Placebo 効果: 41/51 studies demonstrated positive effects on insomnia symptoms None

Review

The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, …

Dose: None vs: Placebo 効果: None None

Review

Integrative sleep management: from molecular pathways to conventional and herbal treatments.

Dose: None vs: Placebo 効果: None None

review

Plants with Potential Importance in Supporting the Treatment of Depression: Current Trends, and Research.

Dose: varies by plant and study vs: Placebo 効果: promising results for saffron, turmeric, ginkgo, St. John's wort, passionflower None

Meta-Analysis

Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.

Dose: Various medicinal herbs: Silexan, Kava, Ginkgo biloba, Withania somnifera, Galphimia glauca, Passion vs: Placebo 効果: Silexan MD -3.84 (95% CrI -6.31 to -1.34); Kava MD -2.46 (95% CrI -4.47 to -0.32); Ginkgo biloba MD None

Review

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review.

Dose: None vs: Placebo 効果: None None

Key Statistics

研究数

2820

参加者数

↑

Positive

グレード

Referenced Papers

Efficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks. Review

Pharmaceuticals (Basel, Switzerland) 2026

Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials. Review

Sleep medicine 2025 4 件の引用

Integrative sleep management: from molecular pathways to conventional and herbal treatments. Review

Naunyn-Schmiedeberg's archives of … 2025 4 件の引用

The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs. Review

Molecules (Basel, Switzerland) 2025 2 件の引用

Plants with Potential Importance in Supporting the Treatment of Depression: Current Trends, and Research. Review

Pharmaceuticals (Basel, Switzerland) 2024 9 件の引用

Edible Herbal Medicines as an Alternative to Common Medication for Sleep Disorders: A Review Article. Review

Current neuropharmacology 2024 9 件の引用

Randomized, Double-Blind, Placebo-Controlled, Clinical Study of Passiflora incarnata in Participants With Stress and Sleep Problems. Other

Cureus 2024

Hydroalcoholic extract of Passiflora incarnata improves the autistic-like behavior and neuronal damage in a valproic acid-induced rat model of autism. Other

Journal of traditional … 2023 24 件の引用

Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre-clinical studies published from 2010 to … Systematic Review

Phytotherapy research : … 2023 14 件の引用

Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis. Meta-Analysis

Pharmacological research 2022 51 件の引用

Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep. Systematic Review

Nutrients 2021 85 件の引用

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review. Review

Planta medica 2021 41 件の引用

Use of Plant-Derived Natural Products in Sleep Disturbances. Review

Advances in experimental … 2021 7 件の引用

Sintocalmy, a Passiflora incarnata Based Herbal, Attenuates Morphine Withdrawal in Mice. Other

Neurochemical research 2021 4 件の引用

[Literature research of Passiflora incarnata and discussion of its traditional Chinese medicine properties]. Other

Zhongguo Zhong yao … 2021 3 件の引用

Passiflora incarnata in Neuropsychiatric Disorders-A Systematic Review. Systematic Review

Nutrients 2020 56 件の引用

Endophytic fungi from Passiflora incarnata: an antioxidant compound source. Other

Archives of microbiology 2020 43 件の引用

Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder: a double-blind randomized placebo-controlled study. RCT

International clinical psychopharmacology 2020 20 件の引用

Sleep-inducing effect of Passiflora incarnata L. extract by single and repeated oral administration in rodent animals. Other

Food science & … 2020 12 件の引用

Improvement in neurogenesis and memory function by administration of Passiflora incarnata L. extract applied to sleep disorder in rodent models. Other

Journal of chemical … 2019 34 件の引用

A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. Other

Complementary therapies in … 2019 26 件の引用

Chronic oral administration of Passiflora incarnata extract has no abnormal effects on metabolic and behavioral parameters in mice, except to … Other

Laboratory animal research 2019 5 件の引用

GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Systematic Review

Phytotherapy research : … 2018 95 件の引用

A review of effective herbal medicines in controlling menopausal symptoms. Review

Electronic physician 2017 102 件の引用

Role Identification of Passiflora Incarnata Linnaeus: A Mini Review. Review

Journal of menopausal … 2017 40 件の引用

Effect of a medicinal plant (Passiflora incarnata L) on sleep. Other

Sleep science (Sao … 2017 32 件の引用

Standardized Passiflora incarnata L. Extract Reverts the Analgesia Induced by Alcohol Withdrawal in Rats. Other

Phytotherapy research : … 2017 12 件の引用

Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial. RCT

Indian journal of … 2013

Passiflora incarnata L.: ethnopharmacology, clinical application, safety and evaluation of clinical trials. Review

Journal of ethnopharmacology 2013

Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L. Other

Phytotherapy research : … 2011

Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. Systematic Review

Nutrition journal 2010 187 件の引用

Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. Review

Medical science monitor … 2009 85 件の引用

Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors. Other

BMC complementary and … 2007

Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. Review

Journal of psychopharmacology … 2005 176 件の引用

Management of insomnia: a place for traditional herbal remedies. Other

Prescrire international 2005 2 件の引用

Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence. Review

Journal of clinical … 2005

Safety and efficacy of herbal sedatives in cancer care. Review

Integrative cancer therapies 2004 59 件の引用

Drug/substance reversal effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn.--a brief perspective. Review

Addiction biology 2003

Attenuation of benzodiazepine dependence in mice by a tri-substituted benzoflavone moiety of Passiflora incarnata Linneaus: a non-habit forming anxiolytic. Other

Journal of pharmacy … 2003

Anxiety, depression, and insomnia. Review

Primary care 2002 43 件の引用

Anti-anxiety studies on extracts of Passiflora incarnata Linneaus. Other

Journal of ethnopharmacology 2001

[Nature medicine as intoxicant]. Case Report

Tidsskrift for den … 1997

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

sleep:: 250-500 mg extract or 1-2 cups tea, before bed

上限量： Not established

研究で検討された用量

用量	期間	効果	N
None	--	Positive	51
None	--	Positive	--
None	--	Positive	--
varies by plant and study	--	Positive	--
Various medicinal herbs: Silexan, Kava, Ginkgo biloba, Withania somnifera, Galphimia glauca, Passion	--	Positive	--
None	--	Positive	--
varies by product and study	--	Mixed	--
Various Passiflora incarnata preparations (doses not specified in abstract)	--	Positive	--

推奨摂取タイミング： 30-60 minutes before bed

Safety & Side Effects

報告されている副作用

⚠ Drowsiness
⚠ Dizziness
⚠ Confusion at high doses
⚠ Nausea

既知の相互作用

● Sedatives and benzodiazepines — additive CNS depression
● Blood thinners — passionflower may increase bleeding risk
● MAOIs — passionflower contains harmala alkaloids

耐容上限摂取量： Not established

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does パッションフラワー help with 不眠症?

Based on 20 studies with 2,820 participants, there is strong evidence from multiple clinical trials that パッションフラワー may support 不眠症 management. Our evidence grade is A (Strong Evidence).

How much パッションフラワー should I take for 不眠症?

Studies have used various dosages. A commonly studied range is 250-500 mg extract or 1-2 cups tea, before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of パッションフラワー?

Reported side effects may include Drowsiness, Dizziness, Confusion at high doses, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for パッションフラワー and 不眠症?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 20 peer-reviewed studies with 2,820 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分：不眠症

メラトニン A バレリアンルート A CBD A オメガ3脂肪酸 A トリプトファン A ビタミンD A

パッションフラワー他の症状・状態について

不安に伴う睡眠障害 A

総合評価

合計2,820名の参加者を対象とした20件の研究（メタアナリシス5件、RCT 1件を含む）に基づく。20件中15件の研究で肯定的な効果が示されている。

Evidence Strength92%

High confidence

研究の内訳

RCT (2)Meta (1)Other (17)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る：不眠症

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

パッションフラワー ： 不眠症

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結論

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

一般的な使用量

研究で検討された用量

Safety & Side Effects

報告されている副作用

既知の相互作用

Frequently Asked Questions

Related Evidence

に関する他の成分： 不眠症

パッションフラワー 他の症状・状態について

パッションフラワー：不眠症

に関する他の成分：不眠症

パッションフラワー他の症状・状態について