パッションフラワー ： 不眠症
A エビデンス 複数の大規模臨床試験が一貫して有意な効果を示しています。合計2,820名の参加者を対象とした20件の研究（メタアナリシス5件、RCT 1件を含む）に基づく。20件中15件の研究で肯定的な効果が示されている。
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'sleepcited.com';
const params = 'ingredient\u003Dpassionflower\u0026condition\u003Dinsomnia';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
A
結論
Passionflower is supported by good evidence as an herbal supplement that may help improve overall sleep quality for people with insomnia.
- 20 studies including 5 meta-analyses support passionflower for insomnia
- 75% of studies report positive effects on sleep
- Research suggests it works through GABA pathways to promote relaxation
- Generally considered safe and well-tolerated based on available evidence
Key Study Findings
Review
n=51
Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials.
Dose: None
vs: Placebo
効果: 41/51 studies demonstrated positive effects on insomnia symptoms
None
Review
The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, …
Dose: None
vs: Placebo
効果: None
None
Review
Integrative sleep management: from molecular pathways to conventional and herbal treatments.
Dose: None
vs: Placebo
効果: None
None
review
Plants with Potential Importance in Supporting the Treatment of Depression: Current Trends, and Research.
Dose: varies by plant and study
vs: Placebo
効果: promising results for saffron, turmeric, ginkgo, St. John's wort, passionflower
None
Meta-Analysis
Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.
Dose: Various medicinal herbs: Silexan, Kava, Ginkgo biloba, Withania somnifera, Galphimia glauca, Passion
vs: Placebo
効果: Silexan MD -3.84 (95% CrI -6.31 to -1.34); Kava MD -2.46 (95% CrI -4.47 to -0.32); Ginkgo biloba MD
None
Review
Medicinal Plants for Insomnia Related to Anxiety: An Updated Review.
Dose: None
vs: Placebo
効果: None
None
Key Statistics
20
研究数
2820
参加者数
↑
Positive
A
グレード
Referenced Papers
Pharmaceuticals (Basel, Switzerland)
2026
Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials.
Review
Sleep medicine
2025
4 件の引用
Naunyn-Schmiedeberg's archives of …
2025
4 件の引用
Molecules (Basel, Switzerland)
2025
2 件の引用
Pharmaceuticals (Basel, Switzerland)
2024
9 件の引用
Current neuropharmacology
2024
9 件の引用
Cureus
2024
Journal of traditional …
2023
24 件の引用
Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre-clinical studies published from 2010 to …
Systematic Review
Phytotherapy research : …
2023
14 件の引用
Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.
Meta-Analysis
Pharmacological research
2022
51 件の引用
Nutrients
2021
85 件の引用
Planta medica
2021
41 件の引用
Advances in experimental …
2021
7 件の引用
Neurochemical research
2021
4 件の引用
Zhongguo Zhong yao …
2021
3 件の引用
Passiflora incarnata in Neuropsychiatric Disorders-A Systematic Review.
Systematic Review
Nutrients
2020
56 件の引用
Archives of microbiology
2020
43 件の引用
International clinical psychopharmacology
2020
20 件の引用
Food science & …
2020
12 件の引用
Journal of chemical …
2019
34 件の引用
Complementary therapies in …
2019
26 件の引用
Laboratory animal research
2019
5 件の引用
GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence.
Systematic Review
Phytotherapy research : …
2018
95 件の引用
Electronic physician
2017
102 件の引用
Journal of menopausal …
2017
40 件の引用
Sleep science (Sao …
2017
32 件の引用
Phytotherapy research : …
2017
12 件の引用
Indian journal of …
2013
Journal of ethnopharmacology
2013
Phytotherapy research : …
2011
Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review.
Systematic Review
Nutrition journal
2010
187 件の引用
Medical science monitor …
2009
85 件の引用
BMC complementary and …
2007
Journal of psychopharmacology …
2005
176 件の引用
Prescrire international
2005
2 件の引用
Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence.
Review
Journal of clinical …
2005
Integrative cancer therapies
2004
59 件の引用
Addiction biology
2003
Journal of pharmacy …
2003
Primary care
2002
43 件の引用
Journal of ethnopharmacology
2001
[Nature medicine as intoxicant].
Case Report
Tidsskrift for den …
1997
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- sleep:
- 250-500 mg extract or 1-2 cups tea, before bed
上限量： Not established
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | 51 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| varies by plant and study | -- | Positive | -- |
| Various medicinal herbs: Silexan, Kava, Ginkgo biloba, Withania somnifera, Galphimia glauca, Passion | -- | Positive | -- |
| None | -- | Positive | -- |
| varies by product and study | -- | Mixed | -- |
| Various Passiflora incarnata preparations (doses not specified in abstract) | -- | Positive | -- |
推奨摂取タイミング： 30-60 minutes before bed
Safety & Side Effects
報告されている副作用
- ⚠ Drowsiness
- ⚠ Dizziness
- ⚠ Confusion at high doses
- ⚠ Nausea
既知の相互作用
- ● Sedatives and benzodiazepines — additive CNS depression
- ● Blood thinners — passionflower may increase bleeding risk
- ● MAOIs — passionflower contains harmala alkaloids
耐容上限摂取量： Not established
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does パッションフラワー help with 不眠症?
Based on 20 studies with 2,820 participants, there is strong evidence from multiple clinical trials that パッションフラワー may support 不眠症 management. Our evidence grade is A (Strong Evidence).
How much パッションフラワー should I take for 不眠症?
Studies have used various dosages. A commonly studied range is 250-500 mg extract or 1-2 cups tea, before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of パッションフラワー?
Reported side effects may include Drowsiness, Dizziness, Confusion at high doses, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for パッションフラワー and 不眠症?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 20 peer-reviewed studies with 2,820 total participants. The overall direction of effect is positive.
Related Evidence
パッションフラワー 他の症状・状態について
References
- [1] Maria-Nina Căuș et al.. Pharmaceuticals (Basel). 2026. Efficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks. doi:10.3390/ph19030399 PubMed
- [2] Adriana Salame et al.. Sleep Med. 2025. Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials. doi:10.1016/j.sleep.2025.02.027 PubMed
- [3] Yasmina M Ebrahim et al.. Naunyn Schmiedebergs Arch Pharmacol. 2025. Integrative sleep management: from molecular pathways to conventional and herbal treatments. doi:10.1007/s00210-025-04183-y PubMed
- [4] Kacper Żełabowski et al.. Molecules. 2025. The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs. doi:10.3390/molecules30183814 PubMed
- [5] Renata Nurzyńska-Wierdak. Pharmaceuticals (Basel). 2024. Plants with Potential Importance in Supporting the Treatment of Depression: Current Trends, and Research. doi:10.3390/ph17111489 PubMed
- [6] Azar Hosseini et al.. Curr Neuropharmacol. 2024. Edible Herbal Medicines as an Alternative to Common Medication for Sleep Disorders: A Review Article. doi:10.2174/1570159X21666230621143944 PubMed
- [7] Mahesh Kumar Harit et al.. Cureus. 2024. Randomized, Double-Blind, Placebo-Controlled, Clinical Study of Passiflora incarnata in Participants With Stress and Sleep Problems. doi:10.7759/cureus.56530 PubMed
- [8] Fatemeh Amini et al.. J Tradit Complement Med. 2023. Hydroalcoholic extract of Passiflora incarnata improves the autistic-like behavior and neuronal damage in a valproic acid-induced rat model of autism. doi:10.1016/j.jtcme.2023.02.005 PubMed
- [9] Constanza Meneses et al.. Phytother Res. 2023. Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre-clinical studies published from 2010 to … doi:10.1002/ptr.7830 PubMed
- [10] Wenting Zhang et al.. Pharmacol Res. 2022. Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis. doi:10.1016/j.phrs.2022.106204 PubMed
- [11] Oliviero Bruni et al.. Nutrients. 2021. Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep. doi:10.3390/nu13020530 PubMed
- [12] Silvia Borrás et al.. Planta Med. 2021. Medicinal Plants for Insomnia Related to Anxiety: An Updated Review. doi:10.1055/a-1510-9826 PubMed
- [13] Diana Lelli et al.. Adv Exp Med Biol. 2021. Use of Plant-Derived Natural Products in Sleep Disturbances. doi:10.1007/978-3-030-64872-5_15 PubMed
- [14] Lucas Dos Reis Izolan et al.. Neurochem Res. 2021. Sintocalmy, a Passiflora incarnata Based Herbal, Attenuates Morphine Withdrawal in Mice. doi:10.1007/s11064-021-03237-w PubMed
- [15] Xin-Juan Hou et al.. Zhongguo Zhong Yao Za Zhi. 2021. [Literature research of Passiflora incarnata and discussion of its traditional Chinese medicine properties]. doi:10.19540/j.cnki.cjcmm.20200915.401 PubMed
- [16] Katarzyna Janda et al.. Nutrients. 2020. Passiflora incarnata in Neuropsychiatric Disorders-A Systematic Review. doi:10.3390/nu12123894 PubMed
- [17] Matheus Henrique Reis da Silva et al.. Arch Microbiol. 2020. Endophytic fungi from Passiflora incarnata: an antioxidant compound source. doi:10.1007/s00203-020-02001-y PubMed
- [18] Jeewon Lee et al.. Int Clin Psychopharmacol. 2020. Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder: a double-blind randomized placebo-controlled study. doi:10.1097/YIC.0000000000000291 PubMed
- [19] Gwang-Ho Kim et al.. Food Sci Nutr. 2020. Sleep-inducing effect of Passiflora incarnata L. extract by single and repeated oral administration in rodent animals. doi:10.1002/fsn3.1341 PubMed
- [20] Gwang-Ho Kim et al.. J Chem Neuroanat. 2019. Improvement in neurogenesis and memory function by administration of Passiflora incarnata L. extract applied to sleep disorder in rodent models. doi:10.1016/j.jchemneu.2019.03.005 PubMed
- [21] Patrick Lemoine et al.. Complement Ther Med. 2019. A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. doi:10.1016/j.ctim.2019.05.024 PubMed
- [22] Gwang-Ho Kim et al.. Lab Anim Res. 2019. Chronic oral administration of Passiflora incarnata extract has no abnormal effects on metabolic and behavioral parameters in mice, except to … doi:10.1186/s42826-019-0034-9 PubMed
- [23] Karen Savage et al.. Phytother Res. 2018. GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. doi:10.1002/ptr.5940 PubMed
- [24] Rahele Kargozar et al.. Electron Physician. 2017. A review of effective herbal medicines in controlling menopausal symptoms. doi:10.19082/5826 PubMed
- [25] Mijin Kim et al.. J Menopausal Med. 2017. Role Identification of Passiflora Incarnata Linnaeus: A Mini Review. doi:10.6118/jmm.2017.23.3.156 PubMed
- [26] Fructuoso Ayala Guerrero et al.. Sleep Sci. 2017. Effect of a medicinal plant (Passiflora incarnata L) on sleep. doi:10.5935/1984-0063.20170018 PubMed
- [27] Rebeca Vargas Antunes Schunck et al.. Phytother Res. 2017. Standardized Passiflora incarnata L. Extract Reverts the Analgesia Induced by Alcohol Withdrawal in Rats. doi:10.1002/ptr.5839 PubMed
- [28] Niteeka Maroo et al.. Indian J Pharmacol. 2013. Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial. doi:10.4103/0253-7613.106432 PubMed
- [29] M Miroddi et al.. J Ethnopharmacol. 2013. Passiflora incarnata L.: ethnopharmacology, clinical application, safety and evaluation of clinical trials. doi:10.1016/j.jep.2013.09.047 PubMed
- [30] Kurt Appel et al.. Phytother Res. 2011. Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L. doi:10.1002/ptr.3352 PubMed
- [31] Shaheen E Lakhan et al.. Nutr J. 2010. Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. doi:10.1186/1475-2891-9-42 PubMed
- [32] Benjamin S Weeks. Med Sci Monit. 2009. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. PubMed
- [33] Marjan Nassiri-Asl et al.. BMC Complement Altern Med. 2007. Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors. doi:10.1186/1472-6882-7-26 PubMed
- [34] David Wheatley. J Psychopharmacol. 2005. Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. doi:10.1177/0269881105053309 PubMed
- [35] . Prescrire Int. 2005. Management of insomnia: a place for traditional herbal remedies. PubMed
- [36] Amy Lynn Meolie et al.. J Clin Sleep Med. 2005. Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence. PubMed
- [37] Keith I Block et al.. Integr Cancer Ther. 2004. Safety and efficacy of herbal sedatives in cancer care. doi:10.1177/1534735404265003 PubMed
- [38] Kamaldeep Dhawan. Addict Biol. 2003. Drug/substance reversal effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn.--a brief perspective. doi:10.1080/13556210310001646385 PubMed
- [39] Kamaldeep Dhawan et al.. J Pharm Pharm Sci. 2003. Attenuation of benzodiazepine dependence in mice by a tri-substituted benzoflavone moiety of Passiflora incarnata Linneaus: a non-habit forming anxiolytic. PubMed
- [40] Michele M Larzelere et al.. Prim Care. 2002. Anxiety, depression, and insomnia. doi:10.1016/s0095-4543(01)00003-3 PubMed
- [41] K Dhawan et al.. J Ethnopharmacol. 2001. Anti-anxiety studies on extracts of Passiflora incarnata Linneaus. doi:10.1016/s0378-8741(01)00339-7 PubMed
- [42] A M Solbakken et al.. Tidsskr Nor Laegeforen. 1997. [Nature medicine as intoxicant]. PubMed
FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。