Melisa için Uykusuzluk
A21 çalışmaya (3 meta-analyses, 2 RCTs), toplam 933 katılımcıyla dayanmaktadır. 17/21 çalışma olumlu etkiler göstermektedir.
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A
Sonuç
Lemon balm is well-supported by research as a gentle, natural supplement that may help improve sleep quality for people with insomnia.
- 17 out of 21 studies show positive effects, with Grade A evidence rating
- A 2023 double-blind RCT showed improved sleep and emotional well-being in adults
- Works through GABA-modulating properties confirmed in multiple systematic reviews
- Effective both alone and in combination with other herbs like valerian
Key Study Findings
systematic review
n=451
Double-blind
Effectiveness of Homoeopathic Treatments for Sleep Disorders in Children and Adolescents: A Systematic Review According …
Dose: various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa
vs: Placebo
Etki: bruxism: ΔVAS -2.36 vs -1.72; enuresis: median -2.4 nights/week
0.05 (bruxism); < 0.04 (enures
Review
Integrative sleep management: from molecular pathways to conventional and herbal treatments.
Dose: None
vs: Placebo
Etki: None
None
Review
n=51
Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials.
Dose: None
vs: Placebo
Etki: 41/51 studies demonstrated positive effects on insomnia symptoms
None
Review
The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, …
Dose: None
vs: Placebo
Etki: None
None
Review
Therapeutic potential of hypnotic herbal medicines: A comprehensive review.
Dose: None
vs: None
Outcome: Sleep quality
Etki: None
None
Popülasyon: Insomnia patients
randomized controlled trial
n=100
3 weeks
Double-blind
The possible "calming effect" of subchronic supplementation of a standardised phospholipid carrier-based Melissa officinalis L. …
Dose: 200 mg twice daily (400 mg/day) for 3 weeks
vs: Placebo
Etki: significant improvements in all scores (depression, anxiety, stress, positive/negative affect, menta
<0.001
Key Statistics
22
Çalışmalar
933
Katılımcılar
↑
Positive
A
Derece
Referenced Papers
Naunyn-Schmiedeberg's archives of …
2025
4 atıf
Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials.
Review
Sleep medicine
2025
4 atıf
Molecules (Basel, Switzerland)
2025
2 atıf
Children (Basel, Switzerland)
2025
Phytotherapy research : …
2024
14 atıf
Nutrients
2024
6 atıf
Frontiers in pharmacology
2023
11 atıf
A Perspective on Missing Aspects in Ongoing Purification Research towards Melissa officinalis.
Review
Foods (Basel, Switzerland)
2023
7 atıf
Molecules (Basel, Switzerland)
2022
90 atıf
Nutrients
2021
85 atıf
Combinatorial chemistry & …
2021
16 atıf
Advances in experimental …
2021
7 atıf
Journal of ethnopharmacology
2020
19 atıf
Complementary therapies in …
2019
26 atıf
Assessing insomnia management in community pharmacy setting in Jordan: A simulated patient approach.
Other
PloS one
2019
19 atıf
GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence.
Systematic Review
Phytotherapy research : …
2018
95 atıf
Clinical nutrition ESPEN
2018
78 atıf
Integrative medicine research
2018
18 atıf
Journal of alternative …
2018
15 atıf
Journal of evidence-based …
2017
204 atıf
Electronic physician
2017
102 atıf
Saudi pharmaceutical journal …
2017
19 atıf
Journal of ethnopharmacology
2015
68 atıf
Research in pharmaceutical …
2015
14 atıf
Phytomedicine : international …
2014
30 atıf
Mediterranean journal of …
2011
Medical science monitor …
2009
85 atıf
Revista medico-chirurgicala a …
2008
24 atıf
Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence.
Review
Journal of clinical …
2005
Integrative cancer therapies
2004
59 atıf
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Yaygın Kullanılan Dozajlar
- sleep:
- 300-600 mg extract, before bed
Üst sınır: Not established
Araştırmalarda İncelenen Dozajlar
| Dozaj | Süre | Etki | N |
|---|---|---|---|
| various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa | -- | Positive | 451 |
| None | -- | Positive | -- |
| None | -- | Positive | 51 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 200 mg twice daily (400 mg/day) for 3 weeks | 3 weeks | Positive | 100 |
| varies by product and study | -- | Mixed | -- |
| not specified | -- | Positive | -- |
En iyi alım zamanı: 30-60 minutes before bed
Safety & Side Effects
Bildirilen Yan Etkiler
- ⚠ Nausea
- ⚠ Abdominal pain
- ⚠ Dizziness
- ⚠ Wheezing (rare allergic reaction)
Bilinen Etkileşimler
- ● Thyroid medications — lemon balm may inhibit TSH binding
- ● Sedatives — additive calming effects
- ● Glaucoma medications — may affect intraocular pressure
Tolere edilebilir üst alım: Not established
Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.
Frequently Asked Questions
Does Melisa help with Uykusuzluk?
Based on 22 studies with 933 participants, there is strong evidence from multiple clinical trials that Melisa may support Uykusuzluk management. Our evidence grade is A (Strong Evidence).
How much Melisa should I take for Uykusuzluk?
Studies have used various dosages. A commonly studied range is 300-600 mg extract, before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Melisa?
Reported side effects may include Nausea, Abdominal pain, Dizziness, Wheezing (rare allergic reaction). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Melisa and Uykusuzluk?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 22 peer-reviewed studies with 933 total participants. The overall direction of effect is positive.
Related Evidence
Şu durum için diğer içerikler: Uykusuzluk
Melisa diğer sağlık durumları için
FDA Sorumluluk Reddi: Bu ifadeler Gıda ve İlaç Dairesi (FDA) tarafından değerlendirilmemiştir. Bu web sitesindeki ürünler ve bilgiler herhangi bir hastalığı teşhis etmek, tedavi etmek, iyileştirmek veya önlemek amacıyla tasarlanmamıştır. Sunulan kanıt dereceleri, yayımlanmış hakemli araştırmalarımızın analizine dayanmaktadır ve tıbbi tavsiye niteliği taşımamaktadır. Herhangi bir takviye rejimine başlamadan önce her zaman sağlık uzmanınıza danışın.