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Toronjil para Insomnio

A Evidencia Múltiples ensayos clínicos de gran tamaño muestran de forma consistente beneficios significativos.

Basado en 21 estudios (3 meta-analyses, 2 RCTs) con 933 participantes en total. 17/21 estudios muestran efectos positivos.

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A

Conclusión

Lemon balm is well-supported by research as a gentle, natural supplement that may help improve sleep quality for people with insomnia.

  • 17 out of 21 studies show positive effects, with Grade A evidence rating
  • A 2023 double-blind RCT showed improved sleep and emotional well-being in adults
  • Works through GABA-modulating properties confirmed in multiple systematic reviews
  • Effective both alone and in combination with other herbs like valerian

Key Study Findings

systematic review n=451 Double-blind
Effectiveness of Homoeopathic Treatments for Sleep Disorders in Children and Adolescents: A Systematic Review According …
Dose: various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa vs: Placebo Efecto: bruxism: ΔVAS -2.36 vs -1.72; enuresis: median -2.4 nights/week 0.05 (bruxism); < 0.04 (enures
Review n=51
Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials.
Dose: None vs: Placebo Efecto: 41/51 studies demonstrated positive effects on insomnia symptoms None
Review
Therapeutic potential of hypnotic herbal medicines: A comprehensive review.
Dose: None vs: None Outcome: Sleep quality Efecto: None None

Población: Insomnia patients

randomized controlled trial n=100 3 weeks Double-blind
The possible "calming effect" of subchronic supplementation of a standardised phospholipid carrier-based Melissa officinalis L. …
Dose: 200 mg twice daily (400 mg/day) for 3 weeks vs: Placebo Efecto: significant improvements in all scores (depression, anxiety, stress, positive/negative affect, menta <0.001

Key Statistics

22

Estudios

933

Participantes

Positive

A

Calificación

Referenced Papers

Combinatorial chemistry & … 2021 16 citas
Advances in experimental … 2021 7 citas
Journal of evidence-based … 2017 204 citas
Integrative cancer therapies 2004 59 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

sleep:
300-600 mg extract, before bed

Límite superior: Not established

Dosificaciones estudiadas en la investigación

Dosificación Duración Efecto N
various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa -- Positive 451
None -- Positive --
None -- Positive 51
None -- Positive --
None -- Positive --
200 mg twice daily (400 mg/day) for 3 weeks 3 weeks Positive 100
varies by product and study -- Mixed --
not specified -- Positive --

Mejor momento para tomar: 30-60 minutes before bed

Safety & Side Effects

Efectos secundarios reportados

  • Nausea
  • Abdominal pain
  • Dizziness
  • Wheezing (rare allergic reaction)

Interacciones conocidas

  • Thyroid medications — lemon balm may inhibit TSH binding
  • Sedatives — additive calming effects
  • Glaucoma medications — may affect intraocular pressure

Ingesta máxima tolerable: Not established

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Toronjil help with Insomnio?
Based on 22 studies with 933 participants, there is strong evidence from multiple clinical trials that Toronjil may support Insomnio management. Our evidence grade is A (Strong Evidence).
How much Toronjil should I take for Insomnio?
Studies have used various dosages. A commonly studied range is 300-600 mg extract, before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Toronjil?
Reported side effects may include Nausea, Abdominal pain, Dizziness, Wheezing (rare allergic reaction). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Toronjil and Insomnio?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 22 peer-reviewed studies with 933 total participants. The overall direction of effect is positive.

References

  1. [1] Yasmina M Ebrahim et al.. Naunyn Schmiedebergs Arch Pharmacol. 2025. Integrative sleep management: from molecular pathways to conventional and herbal treatments. doi:10.1007/s00210-025-04183-y PubMed
  2. [2] Adriana Salame et al.. Sleep Med. 2025. Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials. doi:10.1016/j.sleep.2025.02.027 PubMed
  3. [3] Kacper Żełabowski et al.. Molecules. 2025. The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs. doi:10.3390/molecules30183814 PubMed
  4. [4] Kanchan Upreti et al.. Children (Basel). 2025. Effectiveness of Homoeopathic Treatments for Sleep Disorders in Children and Adolescents: A Systematic Review According to the Principles of Evidence-Based … doi:10.3390/children13010045 PubMed
  5. [5] Mahboobeh Ghasemzadeh Rahbardar et al.. Phytother Res. 2024. Therapeutic potential of hypnotic herbal medicines: A comprehensive review. doi:10.1002/ptr.8201 PubMed
  6. [6] Francesco Di Pierro et al.. Nutrients. 2024. Effects of Melissa officinalis Phytosome on Sleep Quality: Results of a Prospective, Double-Blind, Placebo-Controlled, and Cross-Over Study. doi:10.3390/nu16234199 PubMed
  7. [7] Aasiya Bano et al.. Front Pharmacol. 2023. The possible "calming effect" of subchronic supplementation of a standardised phospholipid carrier-based Melissa officinalis L. extract in healthy adults with … doi:10.3389/fphar.2023.1250560 PubMed
  8. [8] Roberto Castro-Muñoz et al.. Foods. 2023. A Perspective on Missing Aspects in Ongoing Purification Research towards Melissa officinalis. doi:10.3390/foods12091916 PubMed
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Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.