Mélisse pour Insomnie
ABasé sur 21 études (3 meta-analyses, 2 RCTs) avec 933 participants au total. 17/21 études montrent des effets positifs.
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A
En conclusion
Lemon balm is well-supported by research as a gentle, natural supplement that may help improve sleep quality for people with insomnia.
- 17 out of 21 studies show positive effects, with Grade A evidence rating
- A 2023 double-blind RCT showed improved sleep and emotional well-being in adults
- Works through GABA-modulating properties confirmed in multiple systematic reviews
- Effective both alone and in combination with other herbs like valerian
Key Study Findings
systematic review
n=451
Double-blind
Effectiveness of Homoeopathic Treatments for Sleep Disorders in Children and Adolescents: A Systematic Review According …
Dose: various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa
vs: Placebo
Effet: bruxism: ΔVAS -2.36 vs -1.72; enuresis: median -2.4 nights/week
0.05 (bruxism); < 0.04 (enures
Review
Integrative sleep management: from molecular pathways to conventional and herbal treatments.
Dose: None
vs: Placebo
Effet: None
None
Review
n=51
Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials.
Dose: None
vs: Placebo
Effet: 41/51 studies demonstrated positive effects on insomnia symptoms
None
Review
The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, …
Dose: None
vs: Placebo
Effet: None
None
Review
Therapeutic potential of hypnotic herbal medicines: A comprehensive review.
Dose: None
vs: None
Outcome: Sleep quality
Effet: None
None
Population: Insomnia patients
randomized controlled trial
n=100
3 weeks
Double-blind
The possible "calming effect" of subchronic supplementation of a standardised phospholipid carrier-based Melissa officinalis L. …
Dose: 200 mg twice daily (400 mg/day) for 3 weeks
vs: Placebo
Effet: significant improvements in all scores (depression, anxiety, stress, positive/negative affect, menta
<0.001
Key Statistics
22
Études
933
Participants
↑
Positive
A
Note
Referenced Papers
Naunyn-Schmiedeberg's archives of …
2025
4 citations
Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials.
Review
Sleep medicine
2025
4 citations
Molecules (Basel, Switzerland)
2025
2 citations
Children (Basel, Switzerland)
2025
Phytotherapy research : …
2024
14 citations
Nutrients
2024
6 citations
Frontiers in pharmacology
2023
11 citations
A Perspective on Missing Aspects in Ongoing Purification Research towards Melissa officinalis.
Review
Foods (Basel, Switzerland)
2023
7 citations
Molecules (Basel, Switzerland)
2022
90 citations
Nutrients
2021
85 citations
Combinatorial chemistry & …
2021
16 citations
Advances in experimental …
2021
7 citations
Journal of ethnopharmacology
2020
19 citations
Complementary therapies in …
2019
26 citations
Assessing insomnia management in community pharmacy setting in Jordan: A simulated patient approach.
Other
PloS one
2019
19 citations
GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence.
Systematic Review
Phytotherapy research : …
2018
95 citations
Clinical nutrition ESPEN
2018
78 citations
Integrative medicine research
2018
18 citations
Journal of alternative …
2018
15 citations
Journal of evidence-based …
2017
204 citations
Electronic physician
2017
102 citations
Saudi pharmaceutical journal …
2017
19 citations
Journal of ethnopharmacology
2015
68 citations
Research in pharmaceutical …
2015
14 citations
Phytomedicine : international …
2014
30 citations
Mediterranean journal of …
2011
Medical science monitor …
2009
85 citations
Revista medico-chirurgicala a …
2008
24 citations
Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence.
Review
Journal of clinical …
2005
Integrative cancer therapies
2004
59 citations
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Posologies couramment utilisées
- sleep:
- 300-600 mg extract, before bed
Limite supérieure : Not established
Posologies étudiées dans la recherche
| Posologie | Durée | Effet | N |
|---|---|---|---|
| various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa | -- | Positive | 451 |
| None | -- | Positive | -- |
| None | -- | Positive | 51 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 200 mg twice daily (400 mg/day) for 3 weeks | 3 weeks | Positive | 100 |
| varies by product and study | -- | Mixed | -- |
| not specified | -- | Positive | -- |
Moment optimal de prise : 30-60 minutes before bed
Safety & Side Effects
Effets indésirables signalés
- ⚠ Nausea
- ⚠ Abdominal pain
- ⚠ Dizziness
- ⚠ Wheezing (rare allergic reaction)
Interactions connues
- ● Thyroid medications — lemon balm may inhibit TSH binding
- ● Sedatives — additive calming effects
- ● Glaucoma medications — may affect intraocular pressure
Apport maximal tolérable : Not established
Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.
Frequently Asked Questions
Does Mélisse help with Insomnie?
Based on 22 studies with 933 participants, there is strong evidence from multiple clinical trials that Mélisse may support Insomnie management. Our evidence grade is A (Strong Evidence).
How much Mélisse should I take for Insomnie?
Studies have used various dosages. A commonly studied range is 300-600 mg extract, before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Mélisse?
Reported side effects may include Nausea, Abdominal pain, Dizziness, Wheezing (rare allergic reaction). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Mélisse and Insomnie?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 22 peer-reviewed studies with 933 total participants. The overall direction of effect is positive.
Related Evidence
Autres ingrédients pour Insomnie
Mélisse pour d'autres pathologies
Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.