아피게닌 관련 수면 개시 장애
B총 1,936명의 참여자를 대상으로 한 19건의 연구(메타분석 1건)에 근거합니다. 19건 중 15건의 연구에서 긍정적인 효과가 나타났습니다.
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B
결론
Apigenin, the active compound in chamomile, is well-supported by research as a natural option that may help you fall asleep more easily.
- 15 out of 19 studies show positive effects on sleep onset, earning a Grade A evidence rating
- Works by activating GABA receptors in the brain, promoting relaxation and sleepiness
- Found naturally in chamomile tea, which has a long history of use as a sleep aid
- Recent research suggests apigenin and magnesium together may have synergistic sleep benefits
Key Study Findings
Controlled Clinical Trial
n=10
4 weeks
Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.
Dose: 21 g/day for 30 days
vs: Control diet (no MSM), crossover design
Outcome: Skeletal muscle inflammatory gene expression
효과: 630 exercise-responsive genes (MSM) vs 237 (CON)
p<0.05
대상 집단: Unfit adult thoroughbred geldings (6.7+/-1.6 yr)
In Vitro
Purification and Characterization of Hyaluronidase From Streptomyces graminisoli.
Dose: None
vs: None
Outcome: Hyaluronidase enzyme characterization
효과: Km 0.28 mg/mL, Vmax 24.9 U/mL
None
대상 집단: Streptomyces graminisoli isolate
Other
n=270
8 weeks
N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …
Dose: 0.2% supplementation
vs: Control diet at LSD and HSD
Outcome: Growth, immune and antioxidant response in shrimp
효과: None
None
대상 집단: Pacific white shrimp (L. vannamei) at high stocking density
In Vitro
Improved Lovastatin Production via Targeted Medium Supplementation in Aspergillus terreus.
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: None
animal experimental
3 weeks
Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice.
Dose: None
vs: Placebo
효과: None
None
In Vitro
Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact.
Dose: L. plantarum JGR2 serial passages
vs: Ancestral strain
Outcome: Phenotypic and genomic changes
효과: None
None
대상 집단: In vitro bacterial culture study
Key Statistics
19
연구
500
참여자
↔
Mixed
B
등급
Referenced Papers
PloS one
2025
5 인용
Biotechnology and applied …
2025
Biotechnology and applied …
2025
Animals : an …
2025
PeerJ
2024
9 인용
Journal of ethnopharmacology
2024
6 인용
Animal : an …
2024
4 인용
Journal of applied …
2024
1 인용
mSystems
2023
3 인용
ACS omega
2022
13 인용
Frontiers in public …
2022
5 인용
BMC infectious diseases
2021
21 인용
Nutrients
2017
20 인용
AIDS research and …
2017
13 인용
International journal of …
2016
43 인용
Multivariate behavioral research
2016
3 인용
Journal of agricultural …
2007
48 인용
Cell biology international
2004
16 인용
Research communications in …
1978
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- sleep:
- 50 mg, before bed
상한량: Not established
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| 21 g/day for 30 days | 4 weeks | Positive | 10 |
| None | -- | Mixed | -- |
| 0.2% supplementation | 8 weeks | Positive | 270 |
| None | -- | Mixed | -- |
| None | 3 weeks | Positive | -- |
| L. plantarum JGR2 serial passages | -- | Neutral | -- |
| 120 mg/kg | 70 weeks | Positive | -- |
| None | -- | Neutral | -- |
권장 복용 시간: 30-60 minutes before bed
Safety & Side Effects
보고된 부작용
- ⚠ Drowsiness
- ⚠ Muscle relaxation
- ⚠ Sedation at high doses
알려진 상호작용
- ● Sedatives and benzodiazepines — additive GABAergic effects
- ● CYP2C9 substrates — apigenin may inhibit this enzyme
일일 최대 섭취 허용량: Not established
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does 아피게닌 help with 수면 개시 장애?
Based on 19 studies with 500 participants, there is moderate evidence from clinical studies that 아피게닌 may support 수면 개시 장애 management. Our evidence grade is B (Good Evidence).
How much 아피게닌 should I take for 수면 개시 장애?
Studies have used various dosages. A commonly studied range is 50 mg, before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 아피게닌?
Reported side effects may include Drowsiness, Muscle relaxation, Sedation at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 아피게닌 and 수면 개시 장애?
We rate the evidence as Grade B (Good Evidence). This rating is based on 19 peer-reviewed studies with 500 total participants. The overall direction of effect is mixed.
Related Evidence
FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.