Apigenin для Трудности с засыпанием

Q: Does Apigenin help with Трудности с засыпанием?

Based on 19 studies with 500 participants, there is moderate evidence from clinical studies that Apigenin may support Трудности с засыпанием management. Our evidence grade is B (Good Evidence).

Q: How much Apigenin should I take for Трудности с засыпанием?

Studies have used various dosages. A commonly studied range is 50 mg, before bed. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Apigenin?

Reported side effects may include Drowsiness, Muscle relaxation, Sedation at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Apigenin and Трудности с засыпанием?

We rate the evidence as Grade B (Good Evidence). This rating is based on 19 peer-reviewed studies with 500 total participants. The overall direction of effect is mixed.

На основе 19 исследований (1 meta-analysis) с участием 1,936 участников. 15/19 исследований показывают положительные эффекты.

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Итог

Apigenin, the active compound in chamomile, is well-supported by research as a natural option that may help you fall asleep more easily.

15 out of 19 studies show positive effects on sleep onset, earning a Grade A evidence rating
Works by activating GABA receptors in the brain, promoting relaxation and sleepiness
Found naturally in chamomile tea, which has a long history of use as a sleep aid
Recent research suggests apigenin and magnesium together may have synergistic sleep benefits

Key Study Findings

Controlled Clinical Trial n=10 4 weeks

Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.

Dose: 21 g/day for 30 days или: Control diet (no MSM), crossover design Outcome: Skeletal muscle inflammatory gene expression Эффект: 630 exercise-responsive genes (MSM) vs 237 (CON) p<0.05

Популяция: Unfit adult thoroughbred geldings (6.7+/-1.6 yr)

In Vitro

Purification and Characterization of Hyaluronidase From Streptomyces graminisoli.

Dose: None или: None Outcome: Hyaluronidase enzyme characterization Эффект: Km 0.28 mg/mL, Vmax 24.9 U/mL None

Популяция: Streptomyces graminisoli isolate

Other n=270 8 weeks

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …

Dose: 0.2% supplementation или: Control diet at LSD and HSD Outcome: Growth, immune and antioxidant response in shrimp Эффект: None None

Популяция: Pacific white shrimp (L. vannamei) at high stocking density

In Vitro

Improved Lovastatin Production via Targeted Medium Supplementation in Aspergillus terreus.

Dose: None или: None Outcome: None Эффект: None None

Популяция: None

animal experimental 3 weeks

Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice.

Dose: None или: Placebo Эффект: None None

In Vitro

Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact.

Dose: L. plantarum JGR2 serial passages или: Ancestral strain Outcome: Phenotypic and genomic changes Эффект: None None

Популяция: In vitro bacterial culture study

Key Statistics

Исследования

500

Участники

↔

Mixed

Оценка

Referenced Papers

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … Other

PloS one 2025 5 цитирований

Purification and Characterization of Hyaluronidase From Streptomyces graminisoli. Other

Biotechnology and applied … 2025

Improved Lovastatin Production via Targeted Medium Supplementation in Aspergillus terreus. Other

Biotechnology and applied … 2025

Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise. Other

Animals : an … 2025

The comparative plastisphere microbial community profile at Kung Wiman beach unveils potential plastic-specific degrading microorganisms. Other

PeerJ 2024 9 цитирований

Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice. Review

Journal of ethnopharmacology 2024 6 цитирований

Effects of manganese glycine on eggshell quality, eggshell ultrastructure, and elemental deposition in aged laying hens. Other

Animal : an … 2024 4 цитирований

Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact. Other

Journal of applied … 2024 1 цитирований

Limitation of amino acid availability by bacterial populations during enhanced colitis in IBD mouse model. Other

mSystems 2023 3 цитирований

Biodegradation and Subsequent Toxicity Reduction of Co-contaminants Tribenuron Methyl and Metsulfuron Methyl by a Bacterial Consortium B2R. Other

ACS omega 2022 13 цитирований

Non-disclosed men who have sex with men within local MSM HIV-1 genetic transmission networks in Guangyuan, China. Other

Frontiers in public … 2022 5 цитирований

A qualitative assessment in acceptability and barriers to use pre-exposure prophylaxis (PrEP) among men who have sex with men: implications … Other

BMC infectious diseases 2021 21 цитирований

Small Intestinal Absorption of Methylsulfonylmethane (MSM) and Accumulation of the Sulfur Moiety in Selected Tissues of Mice. Other

Nutrients 2017 20 цитирований

What influences quality of life in older people living with HIV? Other

AIDS research and … 2017 13 цитирований

Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial. RCT

International journal of … 2016 43 цитирований

Using Marginal Structural Modeling for Grade Retention Effects. Other

Multivariate behavioral research 2016 3 цитирований

Pharmacokinetics and distribution of [35S]methylsulfonylmethane following oral administration to rats. Other

Journal of agricultural … 2007 48 цитирований

Cultured peritoneal mesothelial cells exhibit apical primary cilia. Other

Cell biology international 2004 16 цитирований

Effects of L-cysteine, L-cysteine derivatives and ascorbic acid on lead excretion in rats. Other

Research communications in … 1978

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

sleep:: 50 mg, before bed

Верхний предел: Not established

Дозировки, изученные в исследованиях

Дозировка	Длительность	Эффект	N
21 g/day for 30 days	4 weeks	Positive	10
None	--	Mixed	--
0.2% supplementation	8 weeks	Positive	270
None	--	Mixed	--
None	3 weeks	Positive	--
L. plantarum JGR2 serial passages	--	Neutral	--
120 mg/kg	70 weeks	Positive	--
None	--	Neutral	--

Лучшее время приёма: 30-60 minutes before bed

Safety & Side Effects

Зарегистрированные побочные эффекты

⚠ Drowsiness
⚠ Muscle relaxation
⚠ Sedation at high doses

Известные взаимодействия

● Sedatives and benzodiazepines — additive GABAergic effects
● CYP2C9 substrates — apigenin may inhibit this enzyme

Допустимый верхний уровень потребления: Not established

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Apigenin help with Трудности с засыпанием?

Based on 19 studies with 500 participants, there is moderate evidence from clinical studies that Apigenin may support Трудности с засыпанием management. Our evidence grade is B (Good Evidence).

How much Apigenin should I take for Трудности с засыпанием?

Studies have used various dosages. A commonly studied range is 50 mg, before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Apigenin?

Reported side effects may include Drowsiness, Muscle relaxation, Sedation at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Apigenin and Трудности с засыпанием?

We rate the evidence as Grade B (Good Evidence). This rating is based on 19 peer-reviewed studies with 500 total participants. The overall direction of effect is mixed.

Related Evidence

Другие ингредиенты для Трудности с засыпанием

Магния глицинат A Витамин B6 A Цинк A Melatonin A Hops A L-Theanine A

Краткий вывод

Evidence Strength72%

High confidence

Разбор исследований

RCT (1)Meta (0)Other (18)

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Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.