Apigenin لـ صعوبة بدء النوم

Q: Does Apigenin help with صعوبة بدء النوم?

Based on 19 studies with 500 participants, there is moderate evidence from clinical studies that Apigenin may support صعوبة بدء النوم management. Our evidence grade is B (Good Evidence).

Q: How much Apigenin should I take for صعوبة بدء النوم?

Studies have used various dosages. A commonly studied range is 50 mg, before bed. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Apigenin?

Reported side effects may include Drowsiness, Muscle relaxation, Sedation at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Apigenin and صعوبة بدء النوم?

We rate the evidence as Grade B (Good Evidence). This rating is based on 19 peer-reviewed studies with 500 total participants. The overall direction of effect is mixed.

بناءً على 19 دراسة (1 meta-analysis) بمشاركة 1,936 مشاركًا إجمالاً. 15/19 دراسة تُظهر تأثيرات إيجابية.

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الخلاصة

Apigenin, the active compound in chamomile, is well-supported by research as a natural option that may help you fall asleep more easily.

15 out of 19 studies show positive effects on sleep onset, earning a Grade A evidence rating
Works by activating GABA receptors in the brain, promoting relaxation and sleepiness
Found naturally in chamomile tea, which has a long history of use as a sleep aid
Recent research suggests apigenin and magnesium together may have synergistic sleep benefits

Key Study Findings

Controlled Clinical Trial n=10 4 weeks

Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.

Dose: 21 g/day for 30 days مقابل: Control diet (no MSM), crossover design Outcome: Skeletal muscle inflammatory gene expression التأثير: 630 exercise-responsive genes (MSM) vs 237 (CON) p<0.05

المجتمع المدروس: Unfit adult thoroughbred geldings (6.7+/-1.6 yr)

In Vitro

Purification and Characterization of Hyaluronidase From Streptomyces graminisoli.

Dose: None مقابل: None Outcome: Hyaluronidase enzyme characterization التأثير: Km 0.28 mg/mL, Vmax 24.9 U/mL None

المجتمع المدروس: Streptomyces graminisoli isolate

Other n=270 8 weeks

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …

Dose: 0.2% supplementation مقابل: Control diet at LSD and HSD Outcome: Growth, immune and antioxidant response in shrimp التأثير: None None

المجتمع المدروس: Pacific white shrimp (L. vannamei) at high stocking density

In Vitro

Improved Lovastatin Production via Targeted Medium Supplementation in Aspergillus terreus.

Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: None

animal experimental 3 weeks

Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice.

Dose: None مقابل: Placebo التأثير: None None

In Vitro

Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact.

Dose: L. plantarum JGR2 serial passages مقابل: Ancestral strain Outcome: Phenotypic and genomic changes التأثير: None None

المجتمع المدروس: In vitro bacterial culture study

Key Statistics

الدراسات

500

المشاركون

↔

Mixed

التقييم

Referenced Papers

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … Other

PloS one 2025 5 اقتباسات

Purification and Characterization of Hyaluronidase From Streptomyces graminisoli. Other

Biotechnology and applied … 2025

Improved Lovastatin Production via Targeted Medium Supplementation in Aspergillus terreus. Other

Biotechnology and applied … 2025

Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise. Other

Animals : an … 2025

The comparative plastisphere microbial community profile at Kung Wiman beach unveils potential plastic-specific degrading microorganisms. Other

PeerJ 2024 9 اقتباسات

Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice. Review

Journal of ethnopharmacology 2024 6 اقتباسات

Effects of manganese glycine on eggshell quality, eggshell ultrastructure, and elemental deposition in aged laying hens. Other

Animal : an … 2024 4 اقتباسات

Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact. Other

Journal of applied … 2024 1 اقتباسات

Limitation of amino acid availability by bacterial populations during enhanced colitis in IBD mouse model. Other

mSystems 2023 3 اقتباسات

Biodegradation and Subsequent Toxicity Reduction of Co-contaminants Tribenuron Methyl and Metsulfuron Methyl by a Bacterial Consortium B2R. Other

ACS omega 2022 13 اقتباسات

Non-disclosed men who have sex with men within local MSM HIV-1 genetic transmission networks in Guangyuan, China. Other

Frontiers in public … 2022 5 اقتباسات

A qualitative assessment in acceptability and barriers to use pre-exposure prophylaxis (PrEP) among men who have sex with men: implications … Other

BMC infectious diseases 2021 21 اقتباسات

Small Intestinal Absorption of Methylsulfonylmethane (MSM) and Accumulation of the Sulfur Moiety in Selected Tissues of Mice. Other

Nutrients 2017 20 اقتباسات

What influences quality of life in older people living with HIV? Other

AIDS research and … 2017 13 اقتباسات

Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial. RCT

International journal of … 2016 43 اقتباسات

Using Marginal Structural Modeling for Grade Retention Effects. Other

Multivariate behavioral research 2016 3 اقتباسات

Pharmacokinetics and distribution of [35S]methylsulfonylmethane following oral administration to rats. Other

Journal of agricultural … 2007 48 اقتباسات

Cultured peritoneal mesothelial cells exhibit apical primary cilia. Other

Cell biology international 2004 16 اقتباسات

Effects of L-cysteine, L-cysteine derivatives and ascorbic acid on lead excretion in rats. Other

Research communications in … 1978

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

sleep:: 50 mg, before bed

الحد الأعلى: Not established

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
21 g/day for 30 days	4 weeks	Positive	10
None	--	Mixed	--
0.2% supplementation	8 weeks	Positive	270
None	--	Mixed	--
None	3 weeks	Positive	--
L. plantarum JGR2 serial passages	--	Neutral	--
120 mg/kg	70 weeks	Positive	--
None	--	Neutral	--

أفضل وقت للتناول: 30-60 minutes before bed

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Drowsiness
⚠ Muscle relaxation
⚠ Sedation at high doses

التفاعلات المعروفة

● Sedatives and benzodiazepines — additive GABAergic effects
● CYP2C9 substrates — apigenin may inhibit this enzyme

الحد الأقصى المسموح به: Not established

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Apigenin help with صعوبة بدء النوم?

Based on 19 studies with 500 participants, there is moderate evidence from clinical studies that Apigenin may support صعوبة بدء النوم management. Our evidence grade is B (Good Evidence).

How much Apigenin should I take for صعوبة بدء النوم?

Studies have used various dosages. A commonly studied range is 50 mg, before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Apigenin?

Reported side effects may include Drowsiness, Muscle relaxation, Sedation at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Apigenin and صعوبة بدء النوم?

We rate the evidence as Grade B (Good Evidence). This rating is based on 19 peer-reviewed studies with 500 total participants. The overall direction of effect is mixed.

Related Evidence

مكونات أخرى لـ صعوبة بدء النوم

Magnesium Glycinate A فيتامين B6 A الزنك A Melatonin A Hops A L-Theanine A

الخلاصة السريعة

بناءً على 19 دراسة (1 meta-analysis) بمشاركة 1,936 مشاركًا إجمالاً. 15/19 دراسة تُظهر تأثيرات إيجابية.

Evidence Strength72%

High confidence

تفصيل الدراسات

RCT (1)Meta (0)Other (18)

قارن البدائل

اعرف كيف تقارن المكونات الأخرى لهذه الحالة.

عرض جميع المكونات لـ صعوبة بدء النوم

اعرف المزيد

إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.