Apigenin لـ صعوبة بدء النوم
B الأدلة تدعم ذلك تجربة عشوائية واحدة على الأقل، مع نتائج متسقة في معظمها.بناءً على 19 دراسة (1 meta-analysis) بمشاركة 1,936 مشاركًا إجمالاً. 15/19 دراسة تُظهر تأثيرات إيجابية.
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B
الخلاصة
Apigenin, the active compound in chamomile, is well-supported by research as a natural option that may help you fall asleep more easily.
- 15 out of 19 studies show positive effects on sleep onset, earning a Grade A evidence rating
- Works by activating GABA receptors in the brain, promoting relaxation and sleepiness
- Found naturally in chamomile tea, which has a long history of use as a sleep aid
- Recent research suggests apigenin and magnesium together may have synergistic sleep benefits
Key Study Findings
Controlled Clinical Trial
n=10
4 weeks
Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.
Dose: 21 g/day for 30 days
مقابل: Control diet (no MSM), crossover design
Outcome: Skeletal muscle inflammatory gene expression
التأثير: 630 exercise-responsive genes (MSM) vs 237 (CON)
p<0.05
المجتمع المدروس: Unfit adult thoroughbred geldings (6.7+/-1.6 yr)
In Vitro
Purification and Characterization of Hyaluronidase From Streptomyces graminisoli.
Dose: None
مقابل: None
Outcome: Hyaluronidase enzyme characterization
التأثير: Km 0.28 mg/mL, Vmax 24.9 U/mL
None
المجتمع المدروس: Streptomyces graminisoli isolate
Other
n=270
8 weeks
N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …
Dose: 0.2% supplementation
مقابل: Control diet at LSD and HSD
Outcome: Growth, immune and antioxidant response in shrimp
التأثير: None
None
المجتمع المدروس: Pacific white shrimp (L. vannamei) at high stocking density
In Vitro
Improved Lovastatin Production via Targeted Medium Supplementation in Aspergillus terreus.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: None
animal experimental
3 weeks
Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice.
Dose: None
مقابل: Placebo
التأثير: None
None
In Vitro
Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact.
Dose: L. plantarum JGR2 serial passages
مقابل: Ancestral strain
Outcome: Phenotypic and genomic changes
التأثير: None
None
المجتمع المدروس: In vitro bacterial culture study
Key Statistics
19
الدراسات
500
المشاركون
↔
Mixed
B
التقييم
Referenced Papers
PloS one
2025
5 اقتباسات
Biotechnology and applied …
2025
Biotechnology and applied …
2025
Animals : an …
2025
PeerJ
2024
9 اقتباسات
Journal of ethnopharmacology
2024
6 اقتباسات
Animal : an …
2024
4 اقتباسات
Journal of applied …
2024
1 اقتباسات
mSystems
2023
3 اقتباسات
ACS omega
2022
13 اقتباسات
Frontiers in public …
2022
5 اقتباسات
BMC infectious diseases
2021
21 اقتباسات
Nutrients
2017
20 اقتباسات
AIDS research and …
2017
13 اقتباسات
International journal of …
2016
43 اقتباسات
Multivariate behavioral research
2016
3 اقتباسات
Journal of agricultural …
2007
48 اقتباسات
Cell biology international
2004
16 اقتباسات
Research communications in …
1978
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- sleep:
- 50 mg, before bed
الحد الأعلى: Not established
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| 21 g/day for 30 days | 4 weeks | Positive | 10 |
| None | -- | Mixed | -- |
| 0.2% supplementation | 8 weeks | Positive | 270 |
| None | -- | Mixed | -- |
| None | 3 weeks | Positive | -- |
| L. plantarum JGR2 serial passages | -- | Neutral | -- |
| 120 mg/kg | 70 weeks | Positive | -- |
| None | -- | Neutral | -- |
أفضل وقت للتناول: 30-60 minutes before bed
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Drowsiness
- ⚠ Muscle relaxation
- ⚠ Sedation at high doses
التفاعلات المعروفة
- ● Sedatives and benzodiazepines — additive GABAergic effects
- ● CYP2C9 substrates — apigenin may inhibit this enzyme
الحد الأقصى المسموح به: Not established
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Apigenin help with صعوبة بدء النوم?
Based on 19 studies with 500 participants, there is moderate evidence from clinical studies that Apigenin may support صعوبة بدء النوم management. Our evidence grade is B (Good Evidence).
How much Apigenin should I take for صعوبة بدء النوم?
Studies have used various dosages. A commonly studied range is 50 mg, before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Apigenin?
Reported side effects may include Drowsiness, Muscle relaxation, Sedation at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Apigenin and صعوبة بدء النوم?
We rate the evidence as Grade B (Good Evidence). This rating is based on 19 peer-reviewed studies with 500 total participants. The overall direction of effect is mixed.
Related Evidence
مكونات أخرى لـ صعوبة بدء النوم
References
- [1] Shafaq Fatima. PLoS One. 2025. N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … doi:10.1371/journal.pone.0315819 PubMed
- [2] Doha Nassir et al.. Biotechnol Appl Biochem. 2025. Purification and Characterization of Hyaluronidase From Streptomyces graminisoli. doi:10.1002/bab.2789 PubMed
- [3] Maryam Javanpour et al.. Biotechnol Appl Biochem. 2025. Improved Lovastatin Production via Targeted Medium Supplementation in Aspergillus terreus. doi:10.1002/bab.70025 PubMed
- [4] Madison R Barshick et al.. Animals (Basel). 2025. Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise. doi:10.3390/ani15020215 PubMed
- [5] Nutsuda Chaimusik et al.. PeerJ. 2024. The comparative plastisphere microbial community profile at Kung Wiman beach unveils potential plastic-specific degrading microorganisms. doi:10.7717/peerj.17165 PubMed
- [6] Shujun Wang et al.. J Ethnopharmacol. 2024. Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice. doi:10.1016/j.jep.2023.116973 PubMed
- [7] J Lu et al.. Animal. 2024. Effects of manganese glycine on eggshell quality, eggshell ultrastructure, and elemental deposition in aged laying hens. doi:10.1016/j.animal.2024.101126 PubMed
- [8] Sarvesh V Surve et al.. J Appl Microbiol. 2024. Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact. doi:10.1093/jambio/lxae035 PubMed
- [9] Tanner G Richie et al.. mSystems. 2023. Limitation of amino acid availability by bacterial populations during enhanced colitis in IBD mouse model. doi:10.1128/msystems.00703-23 PubMed
- [10] Samina Anwar et al.. ACS Omega. 2022. Biodegradation and Subsequent Toxicity Reduction of Co-contaminants Tribenuron Methyl and Metsulfuron Methyl by a Bacterial Consortium B2R. doi:10.1021/acsomega.2c01583 PubMed
- [11] Lacuo Zhuoma et al.. Front Public Health. 2022. Non-disclosed men who have sex with men within local MSM HIV-1 genetic transmission networks in Guangyuan, China. doi:10.3389/fpubh.2022.956217 PubMed
- [12] Long Hoang Nguyen et al.. BMC Infect Dis. 2021. A qualitative assessment in acceptability and barriers to use pre-exposure prophylaxis (PrEP) among men who have sex with men: implications … doi:10.1186/s12879-021-06178-5 PubMed
- [13] Thomas Wong et al.. Nutrients. 2017. Small Intestinal Absorption of Methylsulfonylmethane (MSM) and Accumulation of the Sulfur Moiety in Selected Tissues of Mice. doi:10.3390/nu10010019 PubMed
- [14] Jose Catalan et al.. AIDS Res Ther. 2017. What influences quality of life in older people living with HIV? doi:10.1186/s12981-017-0148-9 PubMed
- [15] Angela Notarnicola et al.. Int J Immunopathol Pharmacol. 2016. Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial. doi:10.1177/0394632015622215 PubMed
- [16] Evgeniya Reshetnyak et al.. Multivariate Behav Res. 2016. Using Marginal Structural Modeling for Grade Retention Effects. doi:10.1080/00273171.2016.1200454 PubMed
- [17] Bernadene A Magnuson et al.. J Agric Food Chem. 2007. Pharmacokinetics and distribution of [35S]methylsulfonylmethane following oral administration to rats. doi:10.1021/jf0621469 PubMed
- [18] Stephen D Bird et al.. Cell Biol Int. 2004. Cultured peritoneal mesothelial cells exhibit apical primary cilia. doi:10.1016/j.cellbi.2003.11.014 PubMed
- [19] E F McNiff et al.. Res Commun Chem Pathol Pharmacol. 1978. Effects of L-cysteine, L-cysteine derivatives and ascorbic acid on lead excretion in rats. PubMed
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