Apigenin untuk Kesulitan Onset Tidur

Q: Does Apigenin help with Kesulitan Onset Tidur?

Based on 19 studies with 500 participants, there is moderate evidence from clinical studies that Apigenin may support Kesulitan Onset Tidur management. Our evidence grade is B (Good Evidence).

Q: How much Apigenin should I take for Kesulitan Onset Tidur?

Studies have used various dosages. A commonly studied range is 50 mg, before bed. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Apigenin?

Reported side effects may include Drowsiness, Muscle relaxation, Sedation at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Apigenin and Kesulitan Onset Tidur?

We rate the evidence as Grade B (Good Evidence). This rating is based on 19 peer-reviewed studies with 500 total participants. The overall direction of effect is mixed.

Berdasarkan 19 studi (1 meta-analysis) dengan 1,936 peserta secara total. 15/19 studi menunjukkan efek positif.

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Kesimpulan

Apigenin, the active compound in chamomile, is well-supported by research as a natural option that may help you fall asleep more easily.

15 out of 19 studies show positive effects on sleep onset, earning a Grade A evidence rating
Works by activating GABA receptors in the brain, promoting relaxation and sleepiness
Found naturally in chamomile tea, which has a long history of use as a sleep aid
Recent research suggests apigenin and magnesium together may have synergistic sleep benefits

Key Study Findings

Controlled Clinical Trial n=10 4 weeks

Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.

Dose: 21 g/day for 30 days vs: Control diet (no MSM), crossover design Outcome: Skeletal muscle inflammatory gene expression Efek: 630 exercise-responsive genes (MSM) vs 237 (CON) p<0.05

Populasi: Unfit adult thoroughbred geldings (6.7+/-1.6 yr)

In Vitro

Purification and Characterization of Hyaluronidase From Streptomyces graminisoli.

Dose: None vs: None Outcome: Hyaluronidase enzyme characterization Efek: Km 0.28 mg/mL, Vmax 24.9 U/mL None

Populasi: Streptomyces graminisoli isolate

Other n=270 8 weeks

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …

Dose: 0.2% supplementation vs: Control diet at LSD and HSD Outcome: Growth, immune and antioxidant response in shrimp Efek: None None

Populasi: Pacific white shrimp (L. vannamei) at high stocking density

In Vitro

Improved Lovastatin Production via Targeted Medium Supplementation in Aspergillus terreus.

Dose: None vs: None Outcome: None Efek: None None

Populasi: None

animal experimental 3 weeks

Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice.

Dose: None vs: Placebo Efek: None None

In Vitro

Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact.

Dose: L. plantarum JGR2 serial passages vs: Ancestral strain Outcome: Phenotypic and genomic changes Efek: None None

Populasi: In vitro bacterial culture study

Key Statistics

Studi

500

Peserta

↔

Mixed

Peringkat

Referenced Papers

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … Other

PloS one 2025 5 sitasi

Purification and Characterization of Hyaluronidase From Streptomyces graminisoli. Other

Biotechnology and applied … 2025

Improved Lovastatin Production via Targeted Medium Supplementation in Aspergillus terreus. Other

Biotechnology and applied … 2025

Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise. Other

Animals : an … 2025

The comparative plastisphere microbial community profile at Kung Wiman beach unveils potential plastic-specific degrading microorganisms. Other

PeerJ 2024 9 sitasi

Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice. Review

Journal of ethnopharmacology 2024 6 sitasi

Effects of manganese glycine on eggshell quality, eggshell ultrastructure, and elemental deposition in aged laying hens. Other

Animal : an … 2024 4 sitasi

Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact. Other

Journal of applied … 2024 1 sitasi

Limitation of amino acid availability by bacterial populations during enhanced colitis in IBD mouse model. Other

mSystems 2023 3 sitasi

Biodegradation and Subsequent Toxicity Reduction of Co-contaminants Tribenuron Methyl and Metsulfuron Methyl by a Bacterial Consortium B2R. Other

ACS omega 2022 13 sitasi

Non-disclosed men who have sex with men within local MSM HIV-1 genetic transmission networks in Guangyuan, China. Other

Frontiers in public … 2022 5 sitasi

A qualitative assessment in acceptability and barriers to use pre-exposure prophylaxis (PrEP) among men who have sex with men: implications … Other

BMC infectious diseases 2021 21 sitasi

Small Intestinal Absorption of Methylsulfonylmethane (MSM) and Accumulation of the Sulfur Moiety in Selected Tissues of Mice. Other

Nutrients 2017 20 sitasi

What influences quality of life in older people living with HIV? Other

AIDS research and … 2017 13 sitasi

Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial. RCT

International journal of … 2016 43 sitasi

Using Marginal Structural Modeling for Grade Retention Effects. Other

Multivariate behavioral research 2016 3 sitasi

Pharmacokinetics and distribution of [35S]methylsulfonylmethane following oral administration to rats. Other

Journal of agricultural … 2007 48 sitasi

Cultured peritoneal mesothelial cells exhibit apical primary cilia. Other

Cell biology international 2004 16 sitasi

Effects of L-cysteine, L-cysteine derivatives and ascorbic acid on lead excretion in rats. Other

Research communications in … 1978

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

sleep:: 50 mg, before bed

Batas atas: Not established

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
21 g/day for 30 days	4 weeks	Positive	10
None	--	Mixed	--
0.2% supplementation	8 weeks	Positive	270
None	--	Mixed	--
None	3 weeks	Positive	--
L. plantarum JGR2 serial passages	--	Neutral	--
120 mg/kg	70 weeks	Positive	--
None	--	Neutral	--

Waktu terbaik diminum: 30-60 minutes before bed

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Drowsiness
⚠ Muscle relaxation
⚠ Sedation at high doses

Interaksi yang Diketahui

● Sedatives and benzodiazepines — additive GABAergic effects
● CYP2C9 substrates — apigenin may inhibit this enzyme

Asupan atas yang dapat ditoleransi: Not established

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Apigenin help with Kesulitan Onset Tidur?

Based on 19 studies with 500 participants, there is moderate evidence from clinical studies that Apigenin may support Kesulitan Onset Tidur management. Our evidence grade is B (Good Evidence).

How much Apigenin should I take for Kesulitan Onset Tidur?

Studies have used various dosages. A commonly studied range is 50 mg, before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Apigenin?

Reported side effects may include Drowsiness, Muscle relaxation, Sedation at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Apigenin and Kesulitan Onset Tidur?

We rate the evidence as Grade B (Good Evidence). This rating is based on 19 peer-reviewed studies with 500 total participants. The overall direction of effect is mixed.

Related Evidence

Bahan lain untuk Kesulitan Onset Tidur

Magnesium Glycinate A Vitamin B6 A Seng A Melatonin A Hops A L-Theanine A

Kesimpulan Singkat

Berdasarkan 19 studi (1 meta-analysis) dengan 1,936 peserta secara total. 15/19 studi menunjukkan efek positif.

Evidence Strength72%

High confidence

Rincian Studi

RCT (1)Meta (0)Other (18)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Kesulitan Onset Tidur

Pelajari Lebih Lanjut

Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.