Melatonin untuk Kesulitan Onset Tidur
ABerdasarkan 30 studi (7 meta-analyses, 6 RCTs) dengan 10,634 peserta secara total. 19/30 studi menunjukkan efek positif.
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A
Kesimpulan
Melatonin is strongly supported by research as a supplement that may help you fall asleep faster, which is one of its best-established benefits.
- 30 studies with 10,634 participants, including 7 meta-analyses and 6 RCTs
- About 63% of studies confirm melatonin helps reduce the time it takes to fall asleep
- Dose-response meta-analyses have helped identify effective dosing ranges
- Recognized in clinical guidelines for both adults and children
Key Study Findings
review
Pediatric Insomnia.
Dose: Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other)
vs: Placebo
Efek: CBT-I most effective treatment; melatonin beneficial in children with ASD or ADHD; limited evidence
None
review
Unraveling the connection between the Mediterranean diet and sleep health: from biological mechanisms to clinical …
Dose: Mediterranean diet (high adherence vs. low adherence); polyphenols, omega-3, fiber as key components
vs: Placebo
Efek: None
None
Review
The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, …
Dose: None
vs: Placebo
Efek: None
None
animal study (preclinical)
The therapeutic potential of Ziziphi Spinosae Semen and Polygalae Radix in insomnia management: Insights from …
Dose: not specified (intragastric administration)
vs: Placebo
Efek: None
None
Meta-Analysis
n=1689
Double-blind
Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of …
Dose: melatonin (various doses, peak efficacy at 4 mg/day)
vs: Placebo
Efek: Melatonin reduces sleep onset latency and increases total sleep time, peaking at 4 mg/day; insomnia
insomnia status p<0.001; time
animal study (preclinical)
4 weeks
Shen Yuan extract exerts a hypnotic effect via the tryptophan/5-hydroxytryptamine/melatonin pathway in mice.
Dose: 0.5 g/kg and 1.0 g/kg intragastrically
vs: Placebo
Efek: None
None
Key Statistics
30
Studi
10634
Peserta
↑
Positive
A
Peringkat
Referenced Papers
Pediatric Insomnia.
Review
Pediatrics in review
2026
Molecules (Basel, Switzerland)
2025
2 sitasi
Sleep & breathing …
2025
Journal of pineal …
2024
31 sitasi
European journal of …
2024
19 sitasi
Journal of ethnopharmacology
2024
13 sitasi
Journal of ethnopharmacology
2024
13 sitasi
Journal of sleep …
2023
17 sitasi
Sleep medicine reviews
2022
48 sitasi
The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review.
Systematic Review
International journal of …
2022
25 sitasi
Evening wear of blue-blocking glasses for sleep and mood disorders: a systematic review.
Systematic Review
Chronobiology international
2021
47 sitasi
Sleep medicine
2020
41 sitasi
Complementary therapies in …
2019
26 sitasi
Journal of child …
2018
133 sitasi
Drugs & aging
2018
131 sitasi
Journal of clinical …
2017
1097 sitasi
Journal of the …
2017
245 sitasi
Continuum (Minneapolis, Minn.)
2017
132 sitasi
American family physician
2017
124 sitasi
Journal of physiology, …
2016
238 sitasi
Pharmacological interventions for sleepiness and sleep disturbances caused by shift work.
Meta-Analysis
The Cochrane database …
2014
131 sitasi
PloS one
2013
447 sitasi
Circadian rhythm abnormalities.
Case Report
Continuum (Minneapolis, Minn.)
2013
172 sitasi
To sleep or not to sleep: a systematic review of the literature of pharmacological treatments of insomnia in children and …
Systematic Review
Journal of child …
2013
56 sitasi
Journal of pineal …
2012
322 sitasi
Effects of a tart cherry juice beverage on the sleep of older adults with insomnia: a pilot study.
RCT
Journal of medicinal …
2010
157 sitasi
Sleep medicine reviews
2008
46 sitasi
The American journal …
2007
41 sitasi
Neuro endocrinology letters
2002
Journal of sleep …
1996
95 sitasi
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 0.5-3 mg, 30-60 min before bed
- jetlag:
- 0.5-5 mg
Batas atas: No established UL; 5 mg typically considered maximum
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other) | -- | Positive | -- |
| Mediterranean diet (high adherence vs. low adherence); polyphenols, omega-3, fiber as key components | -- | Positive | -- |
| None | -- | Positive | -- |
| not specified (intragastric administration) | -- | Positive | -- |
| melatonin (various doses, peak efficacy at 4 mg/day) | -- | Positive | 1689 |
| 0.5 g/kg and 1.0 g/kg intragastrically | 4 weeks | Positive | -- |
| low-dose melatonin administered 30-60 min before bedtime | -- | Positive | -- |
| variable (prolonged-release melatonin; ramelteon standard doses) | -- | Positive | 4875 |
Waktu terbaik diminum: 30-60 minutes before bed
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Daytime drowsiness
- ⚠ Headache
- ⚠ Dizziness
- ⚠ Nausea
- ⚠ Vivid dreams or nightmares
Interaksi yang Diketahui
- ● Blood thinners (warfarin) — may increase bleeding risk
- ● Immunosuppressants — melatonin may stimulate immune function
- ● Diabetes medications — may affect blood sugar levels
- ● Sedatives and CNS depressants — additive drowsiness
Asupan atas yang dapat ditoleransi: No established UL; 5 mg typically considered maximum
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Frequently Asked Questions
Does Melatonin help with Kesulitan Onset Tidur?
Based on 30 studies with 10,634 participants, there is strong evidence from multiple clinical trials that Melatonin may support Kesulitan Onset Tidur management. Our evidence grade is A (Strong Evidence).
How much Melatonin should I take for Kesulitan Onset Tidur?
Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Melatonin?
Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Melatonin and Kesulitan Onset Tidur?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 30 peer-reviewed studies with 10,634 total participants. The overall direction of effect is positive.
Related Evidence
Bahan lain untuk Kesulitan Onset Tidur
Melatonin untuk kondisi lain
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