Melatonin untuk Gangguan Ritme Sirkadian
A Bukti Beberapa uji klinis besar secara konsisten menunjukkan manfaat yang signifikan.Berdasarkan 104 studi (7 meta-analyses, 6 RCTs) dengan 2,780 peserta secara total. 58/104 studi menunjukkan efek positif.
Kesimpulan
Melatonin is well-supported by strong evidence as a supplement that may help reset disrupted circadian rhythms and internal body clock timing.
- 104 studies including 7 meta-analyses and 6 RCTs — one of melatonin's best-studied uses
- Recognized in clinical practice guidelines for circadian rhythm disorders
- 56% of studies show clearly positive effects; others show mixed or context-dependent results
- Research covers delayed sleep phase, irregular rhythms, and non-24-hour disorders
Key Study Findings
Populasi: Japanese 5-year-old children (45 ASD, 10 non-ASD)
Populasi: None
Populasi: None
Populasi: 4-year-old girl with advanced sleep-wake phase disorder
Populasi: Listeria monocytogenes 10403S and ctaP mutant
Populasi: Patients with irregular sleep-wake rhythm disorder
Key Statistics
176
Studi
4513
Peserta
Mixed
Peringkat
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 0.5-3 mg, 30-60 min before bed
- jetlag:
- 0.5-5 mg
Batas atas: No established UL; 5 mg typically considered maximum
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| None | -- | Positive | 55 |
| None | -- | Neutral | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | 1 |
| 1.57 and 3.67 mM | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| 20 mg or 50 mg tasimelteon daily | 5 weeks | Positive | 322 |
Waktu terbaik diminum: 30-60 minutes before bed
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Daytime drowsiness
- ⚠ Headache
- ⚠ Dizziness
- ⚠ Nausea
- ⚠ Vivid dreams or nightmares
Interaksi yang Diketahui
- ● Blood thinners (warfarin) — may increase bleeding risk
- ● Immunosuppressants — melatonin may stimulate immune function
- ● Diabetes medications — may affect blood sugar levels
- ● Sedatives and CNS depressants — additive drowsiness
Asupan atas yang dapat ditoleransi: No established UL; 5 mg typically considered maximum
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does Melatonin help with Gangguan Ritme Sirkadian?
How much Melatonin should I take for Gangguan Ritme Sirkadian?
Are there side effects of Melatonin?
How strong is the evidence for Melatonin and Gangguan Ritme Sirkadian?
Related Evidence
Melatonin untuk kondisi lain
References
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