Melatonin untuk Gangguan Ritme Sirkadian

Q: Does Melatonin help with Gangguan Ritme Sirkadian?

Based on 176 studies with 4,513 participants, there is strong evidence from multiple clinical trials that Melatonin may support Gangguan Ritme Sirkadian management. Our evidence grade is A (Strong Evidence).

Q: How much Melatonin should I take for Gangguan Ritme Sirkadian?

Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Melatonin?

Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Melatonin and Gangguan Ritme Sirkadian?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 176 peer-reviewed studies with 4,513 total participants. The overall direction of effect is mixed.

Berdasarkan 104 studi (7 meta-analyses, 6 RCTs) dengan 2,780 peserta secara total. 58/104 studi menunjukkan efek positif.

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Kesimpulan

Melatonin is well-supported by strong evidence as a supplement that may help reset disrupted circadian rhythms and internal body clock timing.

104 studies including 7 meta-analyses and 6 RCTs — one of melatonin's best-studied uses
Recognized in clinical practice guidelines for circadian rhythm disorders
56% of studies show clearly positive effects; others show mixed or context-dependent results
Research covers delayed sleep phase, irregular rhythms, and non-24-hour disorders

Key Study Findings

Observational Study n=55

Correlation between sleep problems and morning serum melatonin and ferritin levels in Japanese 5-year-old children …

Dose: None vs: None Outcome: correlation between sleep problems and morning serum melatonin … Efek: None p<0.05

Populasi: Japanese 5-year-old children (45 ASD, 10 non-ASD)

Other

An HPLC-MS-Based Method for Determination of the D- and L- 5-Methyltetrahydrofolate Isomer Ratio in Dietary …

Dose: None vs: None Outcome: separation and quantification of D- and L-5-MTHF diastereomers … Efek: None None

Populasi: None

Other

Identifying potential mechanisms of circadian rhythm-related gene marker prognosis, immune infiltration, and melatonin intervention in …

Dose: None vs: None Outcome: None Efek: None None

Populasi: None

Case Reports n=1 Open-label

A novel CSNK1Dvariant in pediatric advanced sleep-wake phase syndrome.

Dose: None vs: None Outcome: Sleep-wake phase improvement Efek: None None

Populasi: 4-year-old girl with advanced sleep-wake phase disorder

In Vitro

Exogenous L-Cysteine and Its Transport Through CtaP Play a Role in Biofilm Formation, Swimming Motility, …

Dose: 1.57 and 3.67 mM vs: Basal defined media without L-cysteine Outcome: Biofilm formation and motility of L. monocytogenes Efek: None None

Populasi: Listeria monocytogenes 10403S and ctaP mutant

Review

Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment.

Dose: None vs: None Outcome: ISWRD symptom management Efek: None None

Populasi: Patients with irregular sleep-wake rhythm disorder

Key Statistics

176

Studi

4513

Peserta

↔

Mixed

Peringkat

Referenced Papers

An HPLC-MS-Based Method for Determination of the D- and L- 5-Methyltetrahydrofolate Isomer Ratio in Dietary Supplements. Other

Journal of AOAC … 2026

Correlation between sleep problems and morning serum melatonin and ferritin levels in Japanese 5-year-old children with autism spectrum disorder. Other

PCN reports : … 2026

Disruption of the circadian rhythm induces acute pancreatitis via amino acid metabolism-mediated macrophage infiltration. Other

Cellular and molecular … 2026

Shift work sleep disorder. Review

Handbook of clinical … 2025 10 sitasi

Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment. Review

Handbook of clinical … 2025 4 sitasi

Melatonin-Loaded Hydrogel Modulates Circadian Rhythms and Alleviates Oxidative Stress and Inflammation to Promote Wound Healing. Other

ACS applied bio … 2025 4 sitasi

The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs. Review

Molecules (Basel, Switzerland) 2025 2 sitasi

Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics. Other

NPJ science of … 2025 2 sitasi

Melatonin agonist tasimelteon (HETLIOZ®) improves sleep in patients with primary insomnia: A multicenter, randomized, double-blind, placebo-controlled trial. RCT

PloS one 2025 1 sitasi

Delayed sleep-wake phase disorder. Review

JAAPA : official … 2025 1 sitasi

ADHD as a circadian rhythm disorder: evidence and implications for chronotherapy. Other

Frontiers in psychiatry 2025 1 sitasi

Exogenous L-Cysteine and Its Transport Through CtaP Play a Role in Biofilm Formation, Swimming Motility, and Swarming Motility of Listeria … Other

Foods (Basel, Switzerland) 2025 1 sitasi

Unraveling the connection between the Mediterranean diet and sleep health: from biological mechanisms to clinical implications. Review

Sleep & breathing … 2025

A novel CSNK1Dvariant in pediatric advanced sleep-wake phase syndrome. Case Report

Sleep medicine 2025

Identifying potential mechanisms of circadian rhythm-related gene marker prognosis, immune infiltration, and melatonin intervention in thyroid cancer based on bioinformatics … Other

Medicine 2025

A prospective randomized controlled trial of antioxidants in human IVF and embryo culture media. RCT

Human reproduction (Oxford, … 2025

Melatonin, Melatonin Receptors and Sleep: Moving Beyond Traditional Views. Review

Journal of pineal … 2024 40 sitasi

Molecular strategies to enhance the keratinase gene expression and its potential implications in poultry feed industry. Other

Poultry science 2024 17 sitasi

Bipolar Disorder, Circadian Rhythm and Clock Genes. Review

Clinical psychopharmacology and … 2024 14 sitasi

Delayed sleep wake phase disorder in adolescents: an updated review. Review

Current opinion in … 2024 12 sitasi

Inhibition of sulfur assimilation by S-benzyl-L-cysteine: Impacts on growth, photosynthesis, and leaf proteome of maize plants. Other

Plant physiology and … 2024 9 sitasi

The use of prolonged-release melatonin in circadian medicine: a systematic review. Systematic Review

Minerva medica 2024 3 sitasi

A cocktail of histidine, carnosine, cysteine and serine reduces adiposity and improves metabolic health and adipose tissue immunometabolic function in … Other

Biomedicine & pharmacotherapy … 2024 3 sitasi

Synergistic application of atmospheric and room temperature plasma mutagenesis and adaptive laboratory evolution improves the tolerance of Escherichia coli to … Other

Biotechnology journal 2024 3 sitasi

Impact of N-acetyl-L-cysteine on spindle morphology and reactive oxygen species in vitrified/warmed in vitro matured bovine oocytes. Other

Reproduction in domestic … 2024 2 sitasi

Sustained xanthine oxidase inhibitor treat to target urate lowering therapy rewires a tight inflammation serum protein interactome. Other

Research square 2024 1 sitasi

Images: "Too much heat for my non-24-hour sleep-wake disorder!" A case report. Case Report

Journal of clinical … 2024

Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism. Review

International journal of … 2023 146 sitasi

Current Insights into the Risks of Using Melatonin as a Treatment for Sleep Disorders in Older Adults. Review

Clinical interventions in … 2023 41 sitasi

Melatonin as a Chronobiotic with Sleep-promoting Properties. Review

Current neuropharmacology 2023 38 sitasi

Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice. Other

Frontiers in pharmacology 2023 14 sitasi

Colorimetric sensing assay based on aptamer-gold nanoparticles for rapid detection of salivary melatonin to monitor circadian rhythm sleep disorders. Other

Analytica chimica acta 2023 12 sitasi

Circadian rhythm disorders in patients with advanced cancer: a scoping review. Review

Frontiers in oncology 2023 10 sitasi

The Effect of Blindness on Biological Rhythms and the Consequences of Circadian Rhythm Disorder. Other

Turkish journal of … 2023 10 sitasi

RP58 knockdown contributes to hypoxia-ischemia-induced pineal dysfunction and circadian rhythm disruption in neonatal rats. Other

Journal of pineal … 2023 7 sitasi

Objective Diagnosis of Circadian Rhythm Disorders. Other

Journal of clinical … 2023 6 sitasi

Updates and confounding factors in delayed sleep-wake phase disorder. Review

Sleep and biological … 2023 6 sitasi

Targeting neuroendocrine abnormalities in Parkinson's disease with exercise. Other

Frontiers in neuroscience 2023 5 sitasi

N-acetyl-L-cysteine improves the performance of chronic cyclic heat-stressed finisher broilers but has no effect on tissue glutathione levels. Other

British poultry science 2023 4 sitasi

A Novel Home-Based Study of Circadian Rhythms: Design, Rationale, and Methods for the Circadia Study. Other

Sleep 2023 3 sitasi

Prevalence and risk factors of sub-health and circadian rhythm disorder of cortisol, melatonin, and temperature among Chinese midwives. Other

Frontiers in public … 2023 3 sitasi

Melatonin in sleep disorders. Review

Neurologia 2022 78 sitasi

Physiological and pharmacological perspectives of melatonin. Review

Archives of physiology … 2022 69 sitasi

Melatonin in sleep disorders. Review

Neurologia 2022 47 sitasi

Treatment of Circadian Rhythm Sleep-Wake Disorders. Review

Current neuropharmacology 2022 40 sitasi

Hypnotic and Melatonin/Melatonin-Receptor Agonist Treatment in Bipolar Disorder: A Systematic Review and Meta-Analysis. Meta-Analysis

CNS drugs 2022 25 sitasi

The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review. Systematic Review

International journal of … 2022 25 sitasi

Bacillus amyloliquefaciens CU33 fermented feather meal-soybean meal product improves the intestinal morphology to promote the growth performance of broilers. RCT

Poultry science 2022 20 sitasi

Melatonin pretreatment prevents propofol-induced sleep disturbance by modulating circadian rhythm in rats. Other

Experimental neurology 2022 17 sitasi

Is Shift Work Sleep Disorder a Risk Factor for Metabolic Syndrome and Its Components? A Systematic Review of Cross-Sectional Studies. Systematic Review

Metabolic syndrome and … 2022 16 sitasi

Exogenous melatonin protects preimplantation embryo development from decabromodiphenyl ethane-induced circadian rhythm disorder and endogenous melatonin reduction. Other

Environmental pollution (Barking, … 2022 15 sitasi

Sini powder with paroxetine ameliorates major depressive disorder by modulating circadian rhythm: A randomized, double-blind, placebo-controlled trial. RCT

Journal of pineal … 2022 13 sitasi

Culture media, DMSO and efflux affect the antibacterial activity of cisplatin and oxaliplatin. Other

Letters in applied … 2022 7 sitasi

Inhibitory effects of zinc chloride (ZnCl2), n-acetyl-L-cysteine (NAC), and calcium/calmodulin dependent protein kinase II inhibitor (KN93) on Cd2+-induced abnormal cell … Other

The Science of … 2022 4 sitasi

Melatonin supplementation for the treatment of infantile spasms: protocol for a randomised placebo-controlled triple-blind trial. Other

BMJ open 2022 3 sitasi

Self-assembly in systems based on L-cysteine-silver-nitrate aqueous solution: multiscale computer simulation. Other

Soft matter 2022 2 sitasi

Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα-dependent pathway. Other

NPJ Parkinson's disease 2022

Structural basis of the ligand binding and signaling mechanism of melatonin receptors. Other

Nature communications 2022

Circadian Rhythm Sleep-Wake Disorders: a Contemporary Review of Neurobiology, Treatment, and Dysregulation in Neurodegenerative Disease. Review

Neurotherapeutics : the … 2021 73 sitasi

Evening wear of blue-blocking glasses for sleep and mood disorders: a systematic review. Systematic Review

Chronobiology international 2021 47 sitasi

Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1. Other

Clinical and translational … 2021 36 sitasi

Role of circadian rhythm disorders on EMT and tumour-immune interactions in endocrine-related cancers. Review

Endocrine-related cancer 2021 26 sitasi

Biological action of docosahexaenoic acid in a 3D tissue-engineered psoriatic skin model: Focus on the PPAR signaling pathway. Other

Biochimica et biophysica … 2021 19 sitasi

Circadian Rhythm Disorders and Corresponding Functional Brain Abnormalities in Young Female Nurses: A Preliminary Study. Other

Frontiers in neurology 2021 16 sitasi

Neurotherapeutic and antioxidant response of D-ribose-L-Cysteine nutritional dietary supplements on Alzheimer-type hippocampal neurodegeneration induced by cuprizone in adult male wistar … Other

Food and chemical … 2021 7 sitasi

Potential anti-toxic effect of d-ribose-l-cysteine supplement on the reproductive functions of male rats administered cyclophosphamide. Other

Journal of basic … 2021 7 sitasi

The role of pineal microRNA-325 in regulating circadian rhythms after neonatal hypoxic-ischemic brain damage. Other

Neural regeneration research 2021 6 sitasi

Melatonin Receptor Gene Polymorphism in Bipolar-I Disorder. Other

Archives of medical … 2021 6 sitasi

Effects of circadian rhythm disorder on body composition in women aged 31-40 years. Other

Annals of palliative … 2021 5 sitasi

Sleep and Circadian Rhythm Disorder in Bipolar Affective Disorder. Other

Current topics in … 2021 5 sitasi

Insomnia and menopause: a narrative review on mechanisms and treatments. Review

Climacteric : the … 2020 97 sitasi

Sleep Issues in Parkinson's Disease and Their Management. Review

Neurotherapeutics : the … 2020 80 sitasi

The role of melatonin and melatonin receptor agonist in the prevention of sleep disturbances and delirium in intensive care unit … Review

Sleep medicine 2020 44 sitasi

Can Vitamin D and L-Cysteine Co-Supplementation Reduce 25(OH)-Vitamin D Deficiency and the Mortality Associated with COVID-19 in African Americans? Other

Journal of the … 2020 43 sitasi

Circadian Rhythm and Glaucoma: What do We Know? Review

Journal of glaucoma 2020 32 sitasi

Therapy for Insomnia and Circadian Rhythm Disorder in Alzheimer Disease. Review

Current treatment options … 2020 29 sitasi

Effect of L-cysteine, Boswellia serrata, and Whey Protein on the Antioxidant and Physicochemical Properties of Pork Patties. Other

Foods (Basel, Switzerland) 2020 15 sitasi

The effect of jet lag on the human brain: A neuroimaging study. Other

Human brain mapping 2020 15 sitasi

Optimized one-pot derivatization and enantioseparation of cysteine: Application to the study of a dietary supplement. Other

Journal of pharmaceutical … 2020 8 sitasi

Sleep parameters assessed by actigraphy in Fabry's disease patients: a proof-of-concept. Other

Sleep medicine 2020 4 sitasi

Study on the preventive effect of ramelteon on the onset of sleep disorder after general anesthesia in patients with autism … Other

Medicine 2020 4 sitasi

Resetting the late timing of 'night owls' has a positive impact on mental health and performance. RCT

Sleep medicine 2019 102 sitasi

Sleep regularity is associated with sleep-wake and circadian timing, and mediates daytime function in Delayed Sleep-Wake Phase Disorder. RCT

Sleep medicine 2019 50 sitasi

Is Idiopathic Hypersomnia a Circadian Rhythm Disorder? Other

Current sleep medicine … 2019 28 sitasi

Rhythmic changes in Fabry disease: Inversion and non-oscillatory pattern in 6-sulfatoxymelatonin daily profile. Other

Chronobiology international 2019 6 sitasi

Teens Who Can't Sleep: Insomnia or Circadian Rhythm Disorder? Case Report

Journal of the … 2019 5 sitasi

Challenging Circadian Rhythm Disorder Cases. Case Report

Neurologic clinics 2019

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. Review

British journal of … 2018 685 sitasi

Increased sensitivity of the circadian system to light in delayed sleep-wake phase disorder. Other

The Journal of … 2018 61 sitasi

Circadian Rhythm Disturbances in the Blind. Review

Current neurology and … 2018 39 sitasi

A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock. RCT

Chronobiology international 2018 13 sitasi

Non-24-Hour Sleep-Wake Circadian Rhythm Disorder in a Sighted Male With Normal Functioning. Case Report

Journal of clinical … 2018 6 sitasi

Recurrent Chemical Meningitis Due to Parasellar Epidermoid Cyst. Case Report

Cureus 2018 4 sitasi

European guideline for the diagnosis and treatment of insomnia. Other

Journal of sleep … 2017 1691 sitasi

Meal Timing Regulates the Human Circadian System. Other

Current biology : … 2017 455 sitasi

A review of sleep disorders and melatonin. Review

Neurological research 2017 331 sitasi

Melatonin Natural Health Products and Supplements: Presence of Serotonin and Significant Variability of Melatonin Content. Other

Journal of clinical … 2017 226 sitasi

Circadian Rhythm Sleep-Wake Disorders. Review

Continuum (Minneapolis, Minn.) 2017 132 sitasi

Treatment of Sleep Dysfunction in Parkinson's Disease. Review

Current treatment options … 2017 56 sitasi

Melatonin restores hippocampal neural precursor cell proliferation and prevents cognitive deficits induced by jet lag simulation in adult mice. Other

Journal of pineal … 2017 45 sitasi

Diagnosis and Treatment of Non-24-h Sleep-Wake Disorder in the Blind. Review

Drugs 2017 45 sitasi

Sleep Disorders: Circadian Rhythm Sleep-Wake Disorders. Review

FP essentials 2017 15 sitasi

Use of versican variant V3 and versican antisense expression to engineer cultured human skin containing increased content of insoluble elastin. Other

Journal of tissue … 2017 12 sitasi

[The application of N-acetylcysteine in optimization of specific pharmacological therapies]. Review

Polski merkuriusz lekarski … 2017 10 sitasi

MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective. Review

Annual review of … 2016 557 sitasi

Disruption of adolescents' circadian clock: The vicious circle of media use, exposure to light at night, sleep loss and risk … Review

Journal of physiology, … 2016 238 sitasi

L-cysteine protects intestinal integrity, attenuates intestinal inflammation and oxidant stress, and modulates NF-κB and Nrf2 pathways in weaned piglets after … Other

Innate immunity 2016 88 sitasi

Optimization of Corneal Epithelial Progenitor Cell Growth on Bombyx mori Silk Fibroin Membranes. Other

Stem cells international 2016 14 sitasi

Cysteic Acid in Dietary Keratin is Metabolized to Glutathione and Liver Taurine in a Rat Model of Human Digestion. Other

Nutrients 2016 13 sitasi

Non-24-hour sleep-wake syndrome improved by low-dose valproic acid: a case report. Case Report

Neuropsychiatric disease and … 2016 6 sitasi

Protective Effects of AGE and Its Components on Neuroinflammation and Neurodegeneration. Other

Neuromolecular medicine 2016

Tasimelteon for non-24-hour sleep-wake disorder in totally blind people (SET and RESET): two multicentre, randomised, double-masked, placebo-controlled phase 3 trials. RCT

Lancet (London, England) 2015 112 sitasi

Jet Lag and Shift Work Disorder. Review

Sleep medicine clinics 2015 75 sitasi

Non-24-Hour Sleep-Wake Rhythm Disorder in Sighted and Blind Patients. Review

Sleep medicine clinics 2015 67 sitasi

Irregular Sleep-Wake Rhythm Disorder. Review

Sleep medicine clinics 2015 30 sitasi

Tasimelteon for the treatment of non-24-hour sleep-wake disorder. Review

Drugs of today … 2015 15 sitasi

Is melatonin useful for jet lag? Meta-Analysis

Medwave 2015 6 sitasi

Short-term incubation of bovine placentome sections as a tool to study xenobiotic mechanism of action. Other

Reproductive biology 2015 6 sitasi

Forced entrainment by using light therapy, modafinil and melatonin in a sighted patient with non-24-hour sleep-wake disorder. Case Report

Sleep medicine 2015 4 sitasi

[Circadian rhythm sleep-wake disorder (circadian rhythm sleep disorder)]. Review

Nihon rinsho. Japanese … 2015

Circadian Rhythm Disorders and Melatonin Production in 127 Blind Women with and without Light Perception. Other

Journal of biological … 2014 105 sitasi

Sleep-wake pattern following gunshot suprachiasmatic damage. Case Report

Journal of clinical … 2014 19 sitasi

The melatonin receptor agonist is effective for free-running type circadian rhythm sleep disorder: case report on two sighted patients. Case Report

The Tohoku journal … 2014 14 sitasi

Mechanism of action of tasimelteon in non-24 sleep-wake syndrome: treatment for a circadian rhythm disorder in blind patients. Review

CNS spectrums 2014 13 sitasi

Estimation of the melatonin suppression index through clear and yellow-tinted intraocular lenses. Other

Japanese journal of … 2014 3 sitasi

[Effects of ramelteon on a patient with circadian rhythm sleep disorder and mood disorder]. Case Report

Seishin shinkeigaku zasshi … 2014 1 sitasi

Assessment and management of sleep problems in youths with attention-deficit/hyperactivity disorder. Review

Journal of the … 2013 219 sitasi

Circadian rhythm abnormalities. Case Report

Continuum (Minneapolis, Minn.) 2013 172 sitasi

L-cysteine and hydrogen sulfide increase PIP3 and AMPK/PPARγ expression and decrease ROS and vascular inflammation markers in high glucose treated … Other

Journal of cellular … 2013 78 sitasi

A randomized controlled trial with bright light and melatonin for the treatment of delayed sleep phase disorder: effects on subjective … RCT

Journal of biological … 2013 67 sitasi

Circadian rhythm disorders among adolescents: assessment and treatment options. Review

The Medical journal … 2013 59 sitasi

Intrinsic circadian period of sighted patients with circadian rhythm sleep disorder, free-running type. CCT

Biological psychiatry 2013 40 sitasi

[Circadian rhythm sleep disorder]. Review

Nihon rinsho. Japanese … 2013

Circadian typology: a comprehensive review. Review

Chronobiology international 2012 1248 sitasi

The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Other

Frontiers in neurology 2012 27 sitasi

Familial circadian rhythm disorder in the diurnal primate, Macaca mulatta. Other

PloS one 2012 14 sitasi

Shift work disorder case studies: applying management principles in clinical practice. Case Report

The Journal of … 2012

Excitotoxicity triggered by Neurobasal culture medium. Other

PloS one 2011 39 sitasi

Ramelteon for Insomnia Related to Attention-Deficit/Hyperactivity Disorder (ADHD). Other

Psychopharmacology bulletin 2011 1 sitasi

Circadian rhythm sleep disorder, free-running type in a sighted male with severe depression, anxiety, and agoraphobia. Case Report

Journal of clinical … 2011

Understanding and diagnosing shift work disorder. Review

Postgraduate medicine 2011

Light-induced changes of the circadian clock of humans: increasing duration is more effective than increasing light intensity. RCT

Sleep 2011

Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. Review

Advances in therapy 2010 136 sitasi

Melatonin agonists and insomnia. Review

Expert review of … 2010 58 sitasi

Keratinolytic activity of Bacillus subtilis AMR using human hair. Other

Letters in applied … 2010 57 sitasi

Melatonin: pharmacological aspects and clinical trends. Review

The International journal … 2010 55 sitasi

A circadian rhythm sleep disorder: melatonin resets the biological clock. Case Report

The journal of … 2010

Advances in protein-amino acid nutrition of poultry. Review

Amino acids 2009 321 sitasi

Delayed onset of the diurnal melatonin rise in patients with Huntington's disease. Other

Journal of neurology 2009 102 sitasi

The pathophysiology of jet lag. Review

Travel medicine and … 2009 101 sitasi

Circadian rhythm disorders. Review

Seminars in neurology 2009 17 sitasi

[Circadian rhythm sleep disorders]. Review

Tidsskrift for den … 2009 6 sitasi

Sleep timing and circadian phase in delayed sleep phase syndrome. Other

Journal of biological … 2009

[Use of combined treatment with melatonin and clomethiazole in circadian rhythm sleep disorder in the elderly with dementia]. Other

Revista espanola de … 2009

[Delayed sleep phase type sleep disorder and chronotherapy]. Case Report

Turk psikiyatri dergisi … 2009

Tasimelteon, a melatonin agonist for the treatment of insomnia and circadian rhythm sleep disorders. Other

Current opinion in … 2009

The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders. Review

Nature clinical practice. … 2008 139 sitasi

Melatonergic drugs in clinical practice. Review

Arzneimittel-Forschung 2008 89 sitasi

Jet lag: therapeutic use of melatonin and possible application of melatonin analogs. Review

Travel medicine and … 2008 84 sitasi

A clinical approach to circadian rhythm sleep disorders. Review

Sleep medicine 2007 201 sitasi

Methionine sulfoxide reductase A and a dietary supplement S-methyl-L-cysteine prevent Parkinson's-like symptoms. Other

The Journal of … 2007 117 sitasi

Excess dietary L-cysteine, but not L-cystine, is lethal for chicks but not for rats or pigs. Other

The Journal of … 2007 48 sitasi

L-cysteine supplementation prevents exercise-induced alterations in human erythrocyte membrane acetylcholinesterase and Na+,K+-ATPase activities. Other

Clinical chemistry and … 2007 8 sitasi

Clinical management of delayed sleep phase disorder. Review

Behavioral sleep medicine 2007

Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. An American Academy of Sleep Medicine report. Review

Sleep 2007

Circadian rhythm sleep disorders: part I, basic principles, shift work and jet lag disorders. An American Academy of Sleep Medicine … Review

Sleep 2007

Melatonin: Nature's most versatile biological signal? Review

The FEBS journal 2006 56 sitasi

Circadian rhythm disorder in a rare disease: Smith-Magenis syndrome. Other

Molecular and cellular … 2006 54 sitasi

Generation and differentiation of human embryonic stem cell-derived keratinocyte precursors. Other

Tissue engineering 2006 50 sitasi

A new dermal equivalent: the use of dermal fibroblast culture alone without exogenous materials. Other

Journal of dermatological … 2006 39 sitasi

Melatonin: characteristics, concerns, and prospects. Review

Journal of biological … 2005 316 sitasi

Idiopathic chronic sleep onset insomnia in attention-deficit/hyperactivity disorder: a circadian rhythm sleep disorder. Other

Chronobiology international 2005 272 sitasi

The human circadian system in normal and disordered sleep. Review

The Journal of … 2005

Working under daylight intensity lamp: an occupational risk for developing circadian rhythm sleep disorder? Case Report

Chronobiology international 2005

Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappaB activation. Other

Journal of cell … 2004 60 sitasi

Circadian rhythm disorders. Review

Seminars in neurology 2004 16 sitasi

Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists. Review

Sleep medicine 2004

Role of melatonin in the regulation of human circadian rhythms and sleep. Review

Journal of neuroendocrinology 2003 719 sitasi

Melatonin: clinical relevance. Review

Best practice & … 2003 339 sitasi

N-acetyl-L-cysteine prevents DNA damage induced by UVA, UVB and visible radiation in human fibroblasts. Other

Journal of photochemistry … 2003 71 sitasi

Melatonin for the prevention and treatment of jet lag. Systematic Review

The Cochrane database … 2002 154 sitasi

[Melatonin and epilepsy]. Review

Revista de neurologia 2002 35 sitasi

Case study of circadian rhythm sleep disorder following haloperidol treatment: reversal by risperidone and melatonin. Case Report

Chronobiology international 2002

Melatonin in sleep disorders and jet-lag. Review

Neuro endocrinology letters 2002

Melatonin for preventing and treating jet lag. Systematic Review

The Cochrane database … 2001 154 sitasi

Circadian rhythm sleep disorders: pathophysiology and potential approaches to management. Review

CNS drugs 2001 135 sitasi

Thiol homeostasis and supplements in physical exercise. Review

The American journal … 2000 472 sitasi

Melatonin and climactery. Review

Medical science monitor … 2000 11 sitasi

Melatonin for the treatment of handicapped children with severe sleep disorders. Other

Pediatric neurology 2000

Sleep and activity rhythms are related to circadian phase in the blind. Other

Sleep 1999 115 sitasi

Continuous axenic cultivation of Pneumocystis carinii. Other

Proceedings of the … 1999 96 sitasi

Melatonin and clinical application. Review

Reproduction, nutrition, development 1999 64 sitasi

Circadian Rhythm Sleep Disorders. Other

Current treatment options … 1999 23 sitasi

Melatonin and jet-lag. Review

European journal of … 1999

Use of melatonin in the treatment of phase shift and sleep disorders. Review

Advances in experimental … 1999

Circadian rhythm sleep disorder associated with pontine lesion. Case Report

European journal of … 1999

[Usefulness of melatonin for developmental sleep and emotional/behavior disorders--studies of melatonin trial on 50 patients with developmental disorders]. Other

No to hattatsu … 1999

Melatonin and the pineal gland: influence on mammalian seasonal and circadian physiology. Other

Reviews of reproduction 1998 381 sitasi

Correlation between concentrations of melatonin in saliva and serum in patients with delayed sleep phase syndrome. CCT

Therapeutic drug monitoring 1998 93 sitasi

Therapeutic entrainment of circadian rhythm disorder by melatonin in a non-blind patient. Case Report

Journal of neurology 1998 18 sitasi

[Jet lag syndrome]. Review

Nihon rinsho. Japanese … 1998

Treatment of circadian rhythm disorders--melatonin. Review

Chronobiology international 1997 135 sitasi

[Jet lag]. Review

Medecine tropicale : … 1997

Cultivation of rabbit corneal epithelial cells in serum-free medium. Other

Investigative ophthalmology & … 1997

Melatonin and jet lag. Review

The Netherlands journal … 1996 13 sitasi

[Sleep-wakefulness rhythm disorders]. Review

La Revue du … 1996

Influence of diethyl maleate and cysteine on tissue glutathione and growth in broiler chickens. Other

Poultry science 1995 16 sitasi

Light, melatonin and the sleep-wake cycle. Review

Journal of psychiatry … 1994 118 sitasi

Circadian sleep regulation in the absence of light perception: chronic non-24-hour circadian rhythm sleep disorder in a blind man with … Case Report

Sleep 1993

Transplantation of cultured thymic fragments in congenitally athymic and euthymic rats. Culture with deoxyguanosine or cyclosporin A does not influence … Other

Scandinavian journal of … 1992 3 sitasi

Differences in growth requirements between epithelial and stromal cells derived from rat ventral prostate in serum-free primary culture. Other

The Prostate 1990 29 sitasi

Long-term culture of human esophageal explants and cells. Other

Cytotechnology 1990 9 sitasi

Regulation of terminal differentiation of cultured human keratinocytes by vitamin A. Other

Cell 1981 747 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 0.5-3 mg, 30-60 min before bed
jetlag:: 0.5-5 mg

Batas atas: No established UL; 5 mg typically considered maximum

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Positive	55
None	--	Neutral	--
None	--	Mixed	--
None	--	Positive	1
1.57 and 3.67 mM	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--
20 mg or 50 mg tasimelteon daily	5 weeks	Positive	322

Waktu terbaik diminum: 30-60 minutes before bed

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Daytime drowsiness
⚠ Headache
⚠ Dizziness
⚠ Nausea
⚠ Vivid dreams or nightmares

Interaksi yang Diketahui

● Blood thinners (warfarin) — may increase bleeding risk
● Immunosuppressants — melatonin may stimulate immune function
● Diabetes medications — may affect blood sugar levels
● Sedatives and CNS depressants — additive drowsiness

Asupan atas yang dapat ditoleransi: No established UL; 5 mg typically considered maximum

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Frequently Asked Questions

Does Melatonin help with Gangguan Ritme Sirkadian?

Based on 176 studies with 4,513 participants, there is strong evidence from multiple clinical trials that Melatonin may support Gangguan Ritme Sirkadian management. Our evidence grade is A (Strong Evidence).

How much Melatonin should I take for Gangguan Ritme Sirkadian?

Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Melatonin?

Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Melatonin and Gangguan Ritme Sirkadian?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 176 peer-reviewed studies with 4,513 total participants. The overall direction of effect is mixed.

Related Evidence

Melatonin untuk kondisi lain

Insomnia A Jet Lag A Gangguan Tidur Kerja Shift A Kesulitan Onset Tidur A Perubahan Tidur Terkait Usia B

Kesimpulan Singkat

Berdasarkan 104 studi (7 meta-analyses, 6 RCTs) dengan 2,780 peserta secara total. 58/104 studi menunjukkan efek positif.

Evidence Strength92%

High confidence

Rincian Studi

RCT (10)Meta (2)Other (164)

Bandingkan Alternatif

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Pelajari Lebih Lanjut

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