褪黑素（Melatonin）用于昼夜节律障碍

Q: Does 褪黑素（Melatonin） help with 昼夜节律障碍?

Based on 176 studies with 4,513 participants, there is strong evidence from multiple clinical trials that 褪黑素（Melatonin） may support 昼夜节律障碍 management. Our evidence grade is A (Strong Evidence).

Q: How much 褪黑素（Melatonin） should I take for 昼夜节律障碍?

Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of 褪黑素（Melatonin）?

Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for 褪黑素（Melatonin） and 昼夜节律障碍?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 176 peer-reviewed studies with 4,513 total participants. The overall direction of effect is mixed.

基于104项研究（7项荟萃分析、6项RCT），共2,780名参与者。58/104项研究显示积极效果。

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结论

Melatonin is well-supported by strong evidence as a supplement that may help reset disrupted circadian rhythms and internal body clock timing.

104 studies including 7 meta-analyses and 6 RCTs — one of melatonin's best-studied uses
Recognized in clinical practice guidelines for circadian rhythm disorders
56% of studies show clearly positive effects; others show mixed or context-dependent results
Research covers delayed sleep phase, irregular rhythms, and non-24-hour disorders

Key Study Findings

Observational Study n=55

Correlation between sleep problems and morning serum melatonin and ferritin levels in Japanese 5-year-old children …

Dose: None vs: None Outcome: correlation between sleep problems and morning serum melatonin … 效果: None p<0.05

研究人群: Japanese 5-year-old children (45 ASD, 10 non-ASD)

Other

An HPLC-MS-Based Method for Determination of the D- and L- 5-Methyltetrahydrofolate Isomer Ratio in Dietary …

Dose: None vs: None Outcome: separation and quantification of D- and L-5-MTHF diastereomers … 效果: None None

研究人群: None

Other

Identifying potential mechanisms of circadian rhythm-related gene marker prognosis, immune infiltration, and melatonin intervention in …

Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Case Reports n=1 Open-label

A novel CSNK1Dvariant in pediatric advanced sleep-wake phase syndrome.

Dose: None vs: None Outcome: Sleep-wake phase improvement 效果: None None

研究人群: 4-year-old girl with advanced sleep-wake phase disorder

In Vitro

Exogenous L-Cysteine and Its Transport Through CtaP Play a Role in Biofilm Formation, Swimming Motility, …

Dose: 1.57 and 3.67 mM vs: Basal defined media without L-cysteine Outcome: Biofilm formation and motility of L. monocytogenes 效果: None None

研究人群: Listeria monocytogenes 10403S and ctaP mutant

Review

Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment.

Dose: None vs: None Outcome: ISWRD symptom management 效果: None None

研究人群: Patients with irregular sleep-wake rhythm disorder

Key Statistics

176

研究数量

4513

受试者

↔

Mixed

等级

Referenced Papers

An HPLC-MS-Based Method for Determination of the D- and L- 5-Methyltetrahydrofolate Isomer Ratio in Dietary Supplements. Other

Journal of AOAC … 2026

Correlation between sleep problems and morning serum melatonin and ferritin levels in Japanese 5-year-old children with autism spectrum disorder. Other

PCN reports : … 2026

Disruption of the circadian rhythm induces acute pancreatitis via amino acid metabolism-mediated macrophage infiltration. Other

Cellular and molecular … 2026

Shift work sleep disorder. Review

Handbook of clinical … 2025 10 次引用

Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment. Review

Handbook of clinical … 2025 4 次引用

Melatonin-Loaded Hydrogel Modulates Circadian Rhythms and Alleviates Oxidative Stress and Inflammation to Promote Wound Healing. Other

ACS applied bio … 2025 4 次引用

The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs. Review

Molecules (Basel, Switzerland) 2025 2 次引用

Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics. Other

NPJ science of … 2025 2 次引用

Melatonin agonist tasimelteon (HETLIOZ®) improves sleep in patients with primary insomnia: A multicenter, randomized, double-blind, placebo-controlled trial. RCT

PloS one 2025 1 次引用

Delayed sleep-wake phase disorder. Review

JAAPA : official … 2025 1 次引用

ADHD as a circadian rhythm disorder: evidence and implications for chronotherapy. Other

Frontiers in psychiatry 2025 1 次引用

Exogenous L-Cysteine and Its Transport Through CtaP Play a Role in Biofilm Formation, Swimming Motility, and Swarming Motility of Listeria … Other

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Unraveling the connection between the Mediterranean diet and sleep health: from biological mechanisms to clinical implications. Review

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A novel CSNK1Dvariant in pediatric advanced sleep-wake phase syndrome. Case Report

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Identifying potential mechanisms of circadian rhythm-related gene marker prognosis, immune infiltration, and melatonin intervention in thyroid cancer based on bioinformatics … Other

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Melatonin, Melatonin Receptors and Sleep: Moving Beyond Traditional Views. Review

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Bipolar Disorder, Circadian Rhythm and Clock Genes. Review

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Delayed sleep wake phase disorder in adolescents: an updated review. Review

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Inhibition of sulfur assimilation by S-benzyl-L-cysteine: Impacts on growth, photosynthesis, and leaf proteome of maize plants. Other

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The use of prolonged-release melatonin in circadian medicine: a systematic review. Systematic Review

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Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism. Review

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Current Insights into the Risks of Using Melatonin as a Treatment for Sleep Disorders in Older Adults. Review

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Melatonin as a Chronobiotic with Sleep-promoting Properties. Review

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Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice. Other

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Colorimetric sensing assay based on aptamer-gold nanoparticles for rapid detection of salivary melatonin to monitor circadian rhythm sleep disorders. Other

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Circadian rhythm disorders in patients with advanced cancer: a scoping review. Review

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The Effect of Blindness on Biological Rhythms and the Consequences of Circadian Rhythm Disorder. Other

Turkish journal of … 2023 10 次引用

RP58 knockdown contributes to hypoxia-ischemia-induced pineal dysfunction and circadian rhythm disruption in neonatal rats. Other

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Objective Diagnosis of Circadian Rhythm Disorders. Other

Journal of clinical … 2023 6 次引用

Updates and confounding factors in delayed sleep-wake phase disorder. Review

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Targeting neuroendocrine abnormalities in Parkinson's disease with exercise. Other

Frontiers in neuroscience 2023 5 次引用

N-acetyl-L-cysteine improves the performance of chronic cyclic heat-stressed finisher broilers but has no effect on tissue glutathione levels. Other

British poultry science 2023 4 次引用

A Novel Home-Based Study of Circadian Rhythms: Design, Rationale, and Methods for the Circadia Study. Other

Sleep 2023 3 次引用

Prevalence and risk factors of sub-health and circadian rhythm disorder of cortisol, melatonin, and temperature among Chinese midwives. Other

Frontiers in public … 2023 3 次引用

Melatonin in sleep disorders. Review

Neurologia 2022 78 次引用

Physiological and pharmacological perspectives of melatonin. Review

Archives of physiology … 2022 69 次引用

Melatonin in sleep disorders. Review

Neurologia 2022 47 次引用

Treatment of Circadian Rhythm Sleep-Wake Disorders. Review

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Hypnotic and Melatonin/Melatonin-Receptor Agonist Treatment in Bipolar Disorder: A Systematic Review and Meta-Analysis. Meta-Analysis

CNS drugs 2022 25 次引用

The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review. Systematic Review

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Bacillus amyloliquefaciens CU33 fermented feather meal-soybean meal product improves the intestinal morphology to promote the growth performance of broilers. RCT

Poultry science 2022 20 次引用

Melatonin pretreatment prevents propofol-induced sleep disturbance by modulating circadian rhythm in rats. Other

Experimental neurology 2022 17 次引用

Is Shift Work Sleep Disorder a Risk Factor for Metabolic Syndrome and Its Components? A Systematic Review of Cross-Sectional Studies. Systematic Review

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Exogenous melatonin protects preimplantation embryo development from decabromodiphenyl ethane-induced circadian rhythm disorder and endogenous melatonin reduction. Other

Environmental pollution (Barking, … 2022 15 次引用

Sini powder with paroxetine ameliorates major depressive disorder by modulating circadian rhythm: A randomized, double-blind, placebo-controlled trial. RCT

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Culture media, DMSO and efflux affect the antibacterial activity of cisplatin and oxaliplatin. Other

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Inhibitory effects of zinc chloride (ZnCl2), n-acetyl-L-cysteine (NAC), and calcium/calmodulin dependent protein kinase II inhibitor (KN93) on Cd2+-induced abnormal cell … Other

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Melatonin supplementation for the treatment of infantile spasms: protocol for a randomised placebo-controlled triple-blind trial. Other

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Self-assembly in systems based on L-cysteine-silver-nitrate aqueous solution: multiscale computer simulation. Other

Soft matter 2022 2 次引用

Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα-dependent pathway. Other

NPJ Parkinson's disease 2022

Structural basis of the ligand binding and signaling mechanism of melatonin receptors. Other

Nature communications 2022

Circadian Rhythm Sleep-Wake Disorders: a Contemporary Review of Neurobiology, Treatment, and Dysregulation in Neurodegenerative Disease. Review

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Evening wear of blue-blocking glasses for sleep and mood disorders: a systematic review. Systematic Review

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Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1. Other

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The role of pineal microRNA-325 in regulating circadian rhythms after neonatal hypoxic-ischemic brain damage. Other

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Melatonin Receptor Gene Polymorphism in Bipolar-I Disorder. Other

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Is Idiopathic Hypersomnia a Circadian Rhythm Disorder? Other

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Rhythmic changes in Fabry disease: Inversion and non-oscillatory pattern in 6-sulfatoxymelatonin daily profile. Other

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Teens Who Can't Sleep: Insomnia or Circadian Rhythm Disorder? Case Report

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Increased sensitivity of the circadian system to light in delayed sleep-wake phase disorder. Other

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Circadian Rhythm Disturbances in the Blind. Review

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A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock. RCT

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Non-24-Hour Sleep-Wake Circadian Rhythm Disorder in a Sighted Male With Normal Functioning. Case Report

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Melatonin restores hippocampal neural precursor cell proliferation and prevents cognitive deficits induced by jet lag simulation in adult mice. Other

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PloS one 2011 39 次引用

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The American journal … 2000 472 次引用

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Melatonin for the treatment of handicapped children with severe sleep disorders. Other

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Light, melatonin and the sleep-wake cycle. Review

Journal of psychiatry … 1994 118 次引用

Circadian sleep regulation in the absence of light perception: chronic non-24-hour circadian rhythm sleep disorder in a blind man with … Case Report

Sleep 1993

Transplantation of cultured thymic fragments in congenitally athymic and euthymic rats. Culture with deoxyguanosine or cyclosporin A does not influence … Other

Scandinavian journal of … 1992 3 次引用

Differences in growth requirements between epithelial and stromal cells derived from rat ventral prostate in serum-free primary culture. Other

The Prostate 1990 29 次引用

Long-term culture of human esophageal explants and cells. Other

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Regulation of terminal differentiation of cultured human keratinocytes by vitamin A. Other

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Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 0.5-3 mg, 30-60 min before bed
jetlag:: 0.5-5 mg

上限： No established UL; 5 mg typically considered maximum

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Positive	55
None	--	Neutral	--
None	--	Mixed	--
None	--	Positive	1
1.57 and 3.67 mM	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--
20 mg or 50 mg tasimelteon daily	5 weeks	Positive	322

最佳服用时间： 30-60 minutes before bed

Safety & Side Effects

已报告的副作用

⚠ Daytime drowsiness
⚠ Headache
⚠ Dizziness
⚠ Nausea
⚠ Vivid dreams or nightmares

已知相互作用

● Blood thinners (warfarin) — may increase bleeding risk
● Immunosuppressants — melatonin may stimulate immune function
● Diabetes medications — may affect blood sugar levels
● Sedatives and CNS depressants — additive drowsiness

可耐受最高摄入量： No established UL; 5 mg typically considered maximum

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does 褪黑素（Melatonin） help with 昼夜节律障碍?

Based on 176 studies with 4,513 participants, there is strong evidence from multiple clinical trials that 褪黑素（Melatonin） may support 昼夜节律障碍 management. Our evidence grade is A (Strong Evidence).

How much 褪黑素（Melatonin） should I take for 昼夜节律障碍?

Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of 褪黑素（Melatonin）?

Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for 褪黑素（Melatonin） and 昼夜节律障碍?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 176 peer-reviewed studies with 4,513 total participants. The overall direction of effect is mixed.

Related Evidence

褪黑素（Melatonin）用于其他健康状况

失眠 A 时差综合征 A 轮班工作睡眠障碍 A 入睡困难 A 年龄相关性睡眠变化 B

快速结论

基于104项研究（7项荟萃分析、6项RCT），共2,780名参与者。58/104项研究显示积极效果。

Evidence Strength92%

High confidence

研究分析

RCT (10)Meta (2)Other (164)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于昼夜节律障碍

了解更多

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