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褪黑素(Melatonin) 用于 轮班工作睡眠障碍

A 证据 多项大型临床试验一致显示出显著的益处。

基于33项研究(4项荟萃分析、2项RCT),共1,917名参与者。19/33项研究显示积极效果。

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A

结论

Melatonin may help shift workers get better sleep by supporting the body's adjustment to irregular schedules, though results can vary from person to person.

  • 33 studies including 4 meta-analyses and 2 RCTs examine this use
  • 58% of studies show positive effects for shift work sleep problems
  • Systematic reviews of healthcare workers specifically support melatonin use
  • Strategic timing of melatonin around desired sleep periods may improve effectiveness

Key Study Findings

review
Shift work sleep disorder.
Dose: melatonin, light therapy, prescription medications (modafinil/armodafinil); optimized shift schedule vs: Placebo 效果: None None
In Vitro
Exogenous L-Cysteine and Its Transport Through CtaP Play a Role in Biofilm Formation, Swimming Motility, …
Dose: 1.57 and 3.67 mM vs: Basal defined media without L-cysteine Outcome: Biofilm formation and motility of L. monocytogenes 效果: None None

研究人群: Listeria monocytogenes 10403S and ctaP mutant

Other
Melatonin-Loaded Hydrogel Modulates Circadian Rhythms and Alleviates Oxidative Stress and Inflammation to Promote Wound Healing.
Dose: None vs: Wounds without hydrogel Outcome: Wound healing and circadian rhythm modulation 效果: None None

研究人群: Animal wound model with circadian disruption

Review
Circadian rhythms and breast cancer: from molecular level to therapeutic advancements.
Dose: None vs: None Outcome: Inflammatory markers 效果: None None

研究人群: Cancer patients

Other
Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice.
Dose: None vs: None Outcome: Fibrosis markers 效果: None None

研究人群: Mouse model

systematic review
The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A …
Dose: 1–10 mg vs: Placebo 效果: None None

Key Statistics

51

研究数量

1903

受试者

Positive

A

等级

Referenced Papers

Handbook of clinical … 2025 10 次引用
Current neuropharmacology 2022 40 次引用
Journal of environmental … 2022 9 次引用
Chronobiology international 2021 47 次引用
Critical reviews in … 2021 3 次引用
Journal of biological … 2020 110 次引用
Sexual medicine reviews 2018 74 次引用
Current biology : … 2017 455 次引用
FP essentials 2017 15 次引用
Diabetes, obesity & … 2015 132 次引用
Sleep medicine clinics 2015 75 次引用
Pathologie-biologie 2014 467 次引用
Continuum (Minneapolis, Minn.) 2013 172 次引用
Methods in molecular … 2013
Nihon rinsho. Japanese … 2013
Cleveland Clinic journal … 2011 73 次引用
Postgraduate medicine 2011
Journal of pineal … 2011
The International journal … 2010 55 次引用
Current treatment options … 2010
Tidsskrift for den … 2009 6 次引用
Arzneimittel-Forschung 2008 89 次引用
Sleep medicine 2007 201 次引用
Cellular and molecular … 2007 88 次引用
The American journal … 2007 3 次引用
The FEBS journal 2006 56 次引用
Tidsskrift for den … 2006
Bulletin de l'Academie … 2005
Experimental gerontology 2001 178 次引用
Novartis Foundation symposium 2000 47 次引用
Current treatment options … 1999 23 次引用
Postgraduate medical journal 1998 17 次引用
Journal of biological … 1997 255 次引用
Duodecim; laaketieteellinen aikakauskirja 1991

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:
0.5-3 mg, 30-60 min before bed
jetlag:
0.5-5 mg

上限: No established UL; 5 mg typically considered maximum

研究中使用的剂量

剂量 持续时间 效果 N
melatonin, light therapy, prescription medications (modafinil/armodafinil); optimized shift schedule -- Mixed --
1.57 and 3.67 mM -- Mixed --
None -- Positive --
None -- Positive --
None -- Positive --
1–10 mg -- Positive --
None -- Mixed --
Melatonin (various doses); light therapy; chronotherapy (various schedules) -- Positive --

最佳服用时间: 30-60 minutes before bed

Safety & Side Effects

已报告的副作用

  • Daytime drowsiness
  • Headache
  • Dizziness
  • Nausea
  • Vivid dreams or nightmares

已知相互作用

  • Blood thinners (warfarin) — may increase bleeding risk
  • Immunosuppressants — melatonin may stimulate immune function
  • Diabetes medications — may affect blood sugar levels
  • Sedatives and CNS depressants — additive drowsiness

可耐受最高摄入量: No established UL; 5 mg typically considered maximum

在开始服用任何补充剂之前,请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does 褪黑素(Melatonin) help with 轮班工作睡眠障碍?
Based on 51 studies with 1,903 participants, there is strong evidence from multiple clinical trials that 褪黑素(Melatonin) may support 轮班工作睡眠障碍 management. Our evidence grade is A (Strong Evidence).
How much 褪黑素(Melatonin) should I take for 轮班工作睡眠障碍?
Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 褪黑素(Melatonin)?
Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 褪黑素(Melatonin) and 轮班工作睡眠障碍?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 51 peer-reviewed studies with 1,903 total participants. The overall direction of effect is positive.

其他成分用于 轮班工作睡眠障碍

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