褪黑素(Melatonin) 用于 轮班工作睡眠障碍
A 证据 多项大型临床试验一致显示出显著的益处。基于33项研究(4项荟萃分析、2项RCT),共1,917名参与者。19/33项研究显示积极效果。
结论
Melatonin may help shift workers get better sleep by supporting the body's adjustment to irregular schedules, though results can vary from person to person.
- 33 studies including 4 meta-analyses and 2 RCTs examine this use
- 58% of studies show positive effects for shift work sleep problems
- Systematic reviews of healthcare workers specifically support melatonin use
- Strategic timing of melatonin around desired sleep periods may improve effectiveness
Key Study Findings
研究人群: Listeria monocytogenes 10403S and ctaP mutant
研究人群: Animal wound model with circadian disruption
研究人群: Cancer patients
研究人群: Mouse model
Key Statistics
51
研究数量
1903
受试者
Positive
等级
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 0.5-3 mg, 30-60 min before bed
- jetlag:
- 0.5-5 mg
上限: No established UL; 5 mg typically considered maximum
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| melatonin, light therapy, prescription medications (modafinil/armodafinil); optimized shift schedule | -- | Mixed | -- |
| 1.57 and 3.67 mM | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 1–10 mg | -- | Positive | -- |
| None | -- | Mixed | -- |
| Melatonin (various doses); light therapy; chronotherapy (various schedules) | -- | Positive | -- |
最佳服用时间: 30-60 minutes before bed
Safety & Side Effects
已报告的副作用
- ⚠ Daytime drowsiness
- ⚠ Headache
- ⚠ Dizziness
- ⚠ Nausea
- ⚠ Vivid dreams or nightmares
已知相互作用
- ● Blood thinners (warfarin) — may increase bleeding risk
- ● Immunosuppressants — melatonin may stimulate immune function
- ● Diabetes medications — may affect blood sugar levels
- ● Sedatives and CNS depressants — additive drowsiness
可耐受最高摄入量: No established UL; 5 mg typically considered maximum
在开始服用任何补充剂之前,请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does 褪黑素(Melatonin) help with 轮班工作睡眠障碍?
How much 褪黑素(Melatonin) should I take for 轮班工作睡眠障碍?
Are there side effects of 褪黑素(Melatonin)?
How strong is the evidence for 褪黑素(Melatonin) and 轮班工作睡眠障碍?
Related Evidence
其他成分用于 轮班工作睡眠障碍
褪黑素(Melatonin) 用于其他健康状况
References
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