褪黑素（Melatonin）用于轮班工作睡眠障碍

基于33项研究（4项荟萃分析、2项RCT），共1,917名参与者。19/33项研究显示积极效果。

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结论

Melatonin may help shift workers get better sleep by supporting the body's adjustment to irregular schedules, though results can vary from person to person.

33 studies including 4 meta-analyses and 2 RCTs examine this use
58% of studies show positive effects for shift work sleep problems
Systematic reviews of healthcare workers specifically support melatonin use
Strategic timing of melatonin around desired sleep periods may improve effectiveness

Key Study Findings

review

Shift work sleep disorder.

Dose: melatonin, light therapy, prescription medications (modafinil/armodafinil); optimized shift schedule vs: Placebo 效果: None None

In Vitro

Exogenous L-Cysteine and Its Transport Through CtaP Play a Role in Biofilm Formation, Swimming Motility, …

Dose: 1.57 and 3.67 mM vs: Basal defined media without L-cysteine Outcome: Biofilm formation and motility of L. monocytogenes 效果: None None

研究人群: Listeria monocytogenes 10403S and ctaP mutant

Other

Melatonin-Loaded Hydrogel Modulates Circadian Rhythms and Alleviates Oxidative Stress and Inflammation to Promote Wound Healing.

Dose: None vs: Wounds without hydrogel Outcome: Wound healing and circadian rhythm modulation 效果: None None

研究人群: Animal wound model with circadian disruption

Review

Circadian rhythms and breast cancer: from molecular level to therapeutic advancements.

Dose: None vs: None Outcome: Inflammatory markers 效果: None None

研究人群: Cancer patients

Other

Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice.

Dose: None vs: None Outcome: Fibrosis markers 效果: None None

研究人群: Mouse model

systematic review

The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A …

Dose: 1–10 mg vs: Placebo 效果: None None

Key Statistics

研究数量

1903

受试者

↑

Positive

等级

Referenced Papers

Shift work sleep disorder. Review

Handbook of clinical … 2025 10 次引用

Melatonin-Loaded Hydrogel Modulates Circadian Rhythms and Alleviates Oxidative Stress and Inflammation to Promote Wound Healing. Other

ACS applied bio … 2025 4 次引用

Exogenous L-Cysteine and Its Transport Through CtaP Play a Role in Biofilm Formation, Swimming Motility, and Swarming Motility of Listeria … Other

Foods (Basel, Switzerland) 2025 1 次引用

Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes. Review

Diabetes & metabolism … 2024 18 次引用

Circadian rhythms and breast cancer: from molecular level to therapeutic advancements. Review

Journal of cancer … 2024 11 次引用

Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice. Other

Journal of pineal … 2024 9 次引用

Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism. Review

International journal of … 2023 146 次引用

Treatment of Circadian Rhythm Sleep-Wake Disorders. Review

Current neuropharmacology 2022 40 次引用

The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review. Systematic Review

International journal of … 2022 25 次引用

Is Shift Work Sleep Disorder a Risk Factor for Metabolic Syndrome and Its Components? A Systematic Review of Cross-Sectional Studies. Systematic Review

Metabolic syndrome and … 2022 16 次引用

Melatonin: A Potential Antineoplastic Agent in Breast Cancer. Review

Journal of environmental … 2022 9 次引用

Culture media, DMSO and efflux affect the antibacterial activity of cisplatin and oxaliplatin. Other

Letters in applied … 2022 7 次引用

Methods to Assess Melatonin Receptor-Mediated Phase-Shift and Re-entrainment of Rhythmic Behaviors in Mouse Models. Other

Methods in molecular … 2022 1 次引用

Circadian Rhythm Sleep-Wake Disorders: a Contemporary Review of Neurobiology, Treatment, and Dysregulation in Neurodegenerative Disease. Review

Neurotherapeutics : the … 2021 73 次引用

Evening wear of blue-blocking glasses for sleep and mood disorders: a systematic review. Systematic Review

Chronobiology international 2021 47 次引用

Circadian Rhythm Disorders and Corresponding Functional Brain Abnormalities in Young Female Nurses: A Preliminary Study. Other

Frontiers in neurology 2021 16 次引用

The Potential Oncostatic Effects of Melatonin against Prostate Cancer. Review

Critical reviews in … 2021 3 次引用

Novel Approaches for Assessing Circadian Rhythmicity in Humans: A Review. Review

Journal of biological … 2020 110 次引用

Structural basis of ligand recognition at the human MT1 melatonin receptor. Other

Nature 2019 186 次引用

Resetting the late timing of 'night owls' has a positive impact on mental health and performance. RCT

Sleep medicine 2019 102 次引用

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. Review

British journal of … 2018 685 次引用

The Relationship Between Shift Work and Men's Health. Review

Sexual medicine reviews 2018 74 次引用

The use and misuse of exogenous melatonin in the treatment of sleep disorders. Review

Current opinion in … 2018 29 次引用

Meal Timing Regulates the Human Circadian System. Other

Current biology : … 2017 455 次引用

Chronomedicine and type 2 diabetes: shining some light on melatonin. Review

Diabetologia 2017 71 次引用

Melatonin restores hippocampal neural precursor cell proliferation and prevents cognitive deficits induced by jet lag simulation in adult mice. Other

Journal of pineal … 2017 45 次引用

Sleep Disorders: Circadian Rhythm Sleep-Wake Disorders. Review

FP essentials 2017 15 次引用

Keeping circadian time with hormones. Review

Diabetes, obesity & … 2015 132 次引用

Pharmacological interventions for sleepiness and sleep disturbances caused by shift work. Other

Sao Paulo medical … 2015 131 次引用

Jet Lag and Shift Work Disorder. Review

Sleep medicine clinics 2015 75 次引用

Short-term incubation of bovine placentome sections as a tool to study xenobiotic mechanism of action. Other

Reproductive biology 2015 6 次引用

Impacts of shift work on sleep and circadian rhythms. Review

Pathologie-biologie 2014 467 次引用

Pharmacological interventions for sleepiness and sleep disturbances caused by shift work. Meta-Analysis

The Cochrane database … 2014 131 次引用

Circadian rhythm abnormalities. Case Report

Continuum (Minneapolis, Minn.) 2013 172 次引用

Measurement of melatonin and 6-sulphatoxymelatonin. Other

Methods in molecular … 2013

[Circadian rhythm sleep disorder]. Review

Nihon rinsho. Japanese … 2013

Shift work disorder case studies: applying management principles in clinical practice. Case Report

The Journal of … 2012

Jet lag and shift work sleep disorders: how to help reset the internal clock. Review

Cleveland Clinic journal … 2011 73 次引用

Understanding and diagnosing shift work disorder. Review

Postgraduate medicine 2011

Update on the use of melatonin in pediatrics. Review

Journal of pineal … 2011

Melatonin: pharmacological aspects and clinical trends. Review

The International journal … 2010 55 次引用

Ready for takeoff? A critical review of armodafinil and modafinil for the treatment of sleepiness associated with jet lag. Other

Nature and science … 2010 3 次引用

Treatment of shift work disorder and jet lag. Other

Current treatment options … 2010

Complementary and alternative medicine usage for behavioral health indications. Review

Primary care 2010

[Circadian rhythm sleep disorders]. Review

Tidsskrift for den … 2009 6 次引用

Tasimelteon, a melatonin agonist for the treatment of insomnia and circadian rhythm sleep disorders. Other

Current opinion in … 2009

The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders. Review

Nature clinical practice. … 2008 139 次引用

Melatonergic drugs in clinical practice. Review

Arzneimittel-Forschung 2008 89 次引用

Jet lag: therapeutic use of melatonin and possible application of melatonin analogs. Review

Travel medicine and … 2008 84 次引用

A clinical approach to circadian rhythm sleep disorders. Review

Sleep medicine 2007 201 次引用

Chronobiology of sleep in humans. Review

Cellular and molecular … 2007 88 次引用

Circadian rhythmicity and the pharmacologic management of insomnia. Review

The American journal … 2007 3 次引用

Circadian rhythm sleep disorders: part I, basic principles, shift work and jet lag disorders. An American Academy of Sleep Medicine … Review

Sleep 2007

Neurobiological effects of melatonin as related to cancer. Review

European journal of … 2007

Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. An American Academy of Sleep Medicine report. Review

Sleep 2007

Shift work sleep disorder: burden of illness and approaches to management. Review

Drugs 2006 110 次引用

Melatonin: Nature's most versatile biological signal? Review

The FEBS journal 2006 56 次引用

[Rhythms, depressions and light]. Review

Tidsskrift for den … 2006

The human circadian system in normal and disordered sleep. Review

The Journal of … 2005

[Melatonin: what for?]. Review

Bulletin de l'Academie … 2005

Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists. Review

Sleep medicine 2004

Human aging and melatonin. Clinical relevance. Review

Experimental gerontology 2001 178 次引用

Circadian rhythm sleep disorders: pathophysiology and potential approaches to management. Review

CNS drugs 2001 135 次引用

Pathophysiology of human circadian rhythms. Review

Novartis Foundation symposium 2000 47 次引用

Circadian Rhythm Sleep Disorders. Other

Current treatment options … 1999 23 次引用

Use of melatonin in the treatment of phase shift and sleep disorders. Review

Advances in experimental … 1999

Jet-lag and shift work: (2). Therapeutic use of melatonin. Review

Journal of the … 1999

Melatonin and the pineal gland: influence on mammalian seasonal and circadian physiology. Other

Reviews of reproduction 1998 381 次引用

Disorders of the sleep-wake cycle in adults. Review

Postgraduate medical journal 1998 17 次引用

Efficacy of melatonin treatment in jet lag, shift work, and blindness. Review

Journal of biological … 1997 255 次引用

Melatonin: a master hormone and a candidate for universal panacea. Review

Indian journal of … 1996

[Shift work, jet lag and sleep]. Review

Duodecim; laaketieteellinen aikakauskirja 1991

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 0.5-3 mg, 30-60 min before bed
jetlag:: 0.5-5 mg

上限： No established UL; 5 mg typically considered maximum

研究中使用的剂量

剂量	持续时间	效果	N
melatonin, light therapy, prescription medications (modafinil/armodafinil); optimized shift schedule	--	Mixed	--
1.57 and 3.67 mM	--	Mixed	--
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
1–10 mg	--	Positive	--
None	--	Mixed	--
Melatonin (various doses); light therapy; chronotherapy (various schedules)	--	Positive	--

最佳服用时间： 30-60 minutes before bed

Safety & Side Effects

已报告的副作用

⚠ Daytime drowsiness
⚠ Headache
⚠ Dizziness
⚠ Nausea
⚠ Vivid dreams or nightmares

已知相互作用

● Blood thinners (warfarin) — may increase bleeding risk
● Immunosuppressants — melatonin may stimulate immune function
● Diabetes medications — may affect blood sugar levels
● Sedatives and CNS depressants — additive drowsiness

可耐受最高摄入量： No established UL; 5 mg typically considered maximum

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does 褪黑素（Melatonin） help with 轮班工作睡眠障碍?

Based on 51 studies with 1,903 participants, there is strong evidence from multiple clinical trials that 褪黑素（Melatonin） may support 轮班工作睡眠障碍 management. Our evidence grade is A (Strong Evidence).

How much 褪黑素（Melatonin） should I take for 轮班工作睡眠障碍?

Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of 褪黑素（Melatonin）?

Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for 褪黑素（Melatonin） and 轮班工作睡眠障碍?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 51 peer-reviewed studies with 1,903 total participants. The overall direction of effect is positive.

Related Evidence

其他成分用于轮班工作睡眠障碍

L-Ornithine C

褪黑素（Melatonin）用于其他健康状况

失眠 A 昼夜节律障碍 A 时差综合征 A 入睡困难 A 年龄相关性睡眠变化 B

快速结论

基于33项研究（4项荟萃分析、2项RCT），共1,917名参与者。19/33项研究显示积极效果。

Evidence Strength92%

High confidence

研究分析

RCT (1)Meta (1)Other (49)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于轮班工作睡眠障碍

了解更多

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