Melatonin cho Rối Loạn Giấc Ngủ Do Làm Việc Ca
A Bằng chứng Nhiều thử nghiệm lâm sàng lớn liên tục cho thấy những lợi ích đáng kể.Dựa trên 33 nghiên cứu (4 meta-analyses, 2 RCTs) với 1,917 người tham gia. 19/33 nghiên cứu cho thấy tác động tích cực.
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A
Kết luận
Melatonin may help shift workers get better sleep by supporting the body's adjustment to irregular schedules, though results can vary from person to person.
- 33 studies including 4 meta-analyses and 2 RCTs examine this use
- 58% of studies show positive effects for shift work sleep problems
- Systematic reviews of healthcare workers specifically support melatonin use
- Strategic timing of melatonin around desired sleep periods may improve effectiveness
Key Study Findings
review
Shift work sleep disorder.
Dose: melatonin, light therapy, prescription medications (modafinil/armodafinil); optimized shift schedule
so với: Placebo
Hiệu quả: None
None
In Vitro
Exogenous L-Cysteine and Its Transport Through CtaP Play a Role in Biofilm Formation, Swimming Motility, …
Dose: 1.57 and 3.67 mM
so với: Basal defined media without L-cysteine
Outcome: Biofilm formation and motility of L. monocytogenes
Hiệu quả: None
None
Đối tượng nghiên cứu: Listeria monocytogenes 10403S and ctaP mutant
Other
Melatonin-Loaded Hydrogel Modulates Circadian Rhythms and Alleviates Oxidative Stress and Inflammation to Promote Wound Healing.
Dose: None
so với: Wounds without hydrogel
Outcome: Wound healing and circadian rhythm modulation
Hiệu quả: None
None
Đối tượng nghiên cứu: Animal wound model with circadian disruption
Review
Circadian rhythms and breast cancer: from molecular level to therapeutic advancements.
Dose: None
so với: None
Outcome: Inflammatory markers
Hiệu quả: None
None
Đối tượng nghiên cứu: Cancer patients
Other
Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice.
Dose: None
so với: None
Outcome: Fibrosis markers
Hiệu quả: None
None
Đối tượng nghiên cứu: Mouse model
systematic review
The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A …
Dose: 1–10 mg
so với: Placebo
Hiệu quả: None
None
Key Statistics
51
Nghiên cứu
1903
Người tham gia
↑
Positive
A
Xếp hạng
Referenced Papers
Shift work sleep disorder.
Review
Handbook of clinical …
2025
10 trích dẫn
ACS applied bio …
2025
4 trích dẫn
Foods (Basel, Switzerland)
2025
1 trích dẫn
Diabetes & metabolism …
2024
18 trích dẫn
Journal of cancer …
2024
11 trích dẫn
Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice.
Other
Journal of pineal …
2024
9 trích dẫn
International journal of …
2023
146 trích dẫn
Current neuropharmacology
2022
40 trích dẫn
The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review.
Systematic Review
International journal of …
2022
25 trích dẫn
Is Shift Work Sleep Disorder a Risk Factor for Metabolic Syndrome and Its Components? A Systematic Review of Cross-Sectional Studies.
Systematic Review
Metabolic syndrome and …
2022
16 trích dẫn
Journal of environmental …
2022
9 trích dẫn
Culture media, DMSO and efflux affect the antibacterial activity of cisplatin and oxaliplatin.
Other
Letters in applied …
2022
7 trích dẫn
Methods in molecular …
2022
1 trích dẫn
Neurotherapeutics : the …
2021
73 trích dẫn
Evening wear of blue-blocking glasses for sleep and mood disorders: a systematic review.
Systematic Review
Chronobiology international
2021
47 trích dẫn
Frontiers in neurology
2021
16 trích dẫn
Critical reviews in …
2021
3 trích dẫn
Journal of biological …
2020
110 trích dẫn
Nature
2019
186 trích dẫn
Resetting the late timing of 'night owls' has a positive impact on mental health and performance.
RCT
Sleep medicine
2019
102 trích dẫn
New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation.
Review
British journal of …
2018
685 trích dẫn
Sexual medicine reviews
2018
74 trích dẫn
Current opinion in …
2018
29 trích dẫn
Current biology : …
2017
455 trích dẫn
Diabetologia
2017
71 trích dẫn
Journal of pineal …
2017
45 trích dẫn
FP essentials
2017
15 trích dẫn
Diabetes, obesity & …
2015
132 trích dẫn
Sao Paulo medical …
2015
131 trích dẫn
Sleep medicine clinics
2015
75 trích dẫn
Reproductive biology
2015
6 trích dẫn
Pathologie-biologie
2014
467 trích dẫn
Pharmacological interventions for sleepiness and sleep disturbances caused by shift work.
Meta-Analysis
The Cochrane database …
2014
131 trích dẫn
Circadian rhythm abnormalities.
Case Report
Continuum (Minneapolis, Minn.)
2013
172 trích dẫn
Methods in molecular …
2013
Nihon rinsho. Japanese …
2013
The Journal of …
2012
Cleveland Clinic journal …
2011
73 trích dẫn
Postgraduate medicine
2011
Journal of pineal …
2011
The International journal …
2010
55 trích dẫn
Nature and science …
2010
3 trích dẫn
Current treatment options …
2010
Primary care
2010
Tidsskrift for den …
2009
6 trích dẫn
Tasimelteon, a melatonin agonist for the treatment of insomnia and circadian rhythm sleep disorders.
Other
Current opinion in …
2009
Nature clinical practice. …
2008
139 trích dẫn
Arzneimittel-Forschung
2008
89 trích dẫn
Travel medicine and …
2008
84 trích dẫn
Sleep medicine
2007
201 trích dẫn
Cellular and molecular …
2007
88 trích dẫn
The American journal …
2007
3 trích dẫn
Sleep
2007
European journal of …
2007
Sleep
2007
Drugs
2006
110 trích dẫn
The FEBS journal
2006
56 trích dẫn
Tidsskrift for den …
2006
The Journal of …
2005
[Melatonin: what for?].
Review
Bulletin de l'Academie …
2005
Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists.
Review
Sleep medicine
2004
Experimental gerontology
2001
178 trích dẫn
CNS drugs
2001
135 trích dẫn
Novartis Foundation symposium
2000
47 trích dẫn
Current treatment options …
1999
23 trích dẫn
Advances in experimental …
1999
Journal of the …
1999
Reviews of reproduction
1998
381 trích dẫn
Postgraduate medical journal
1998
17 trích dẫn
Journal of biological …
1997
255 trích dẫn
Indian journal of …
1996
Duodecim; laaketieteellinen aikakauskirja
1991
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Liều lượng thường dùng
- general:
- 0.5-3 mg, 30-60 min before bed
- jetlag:
- 0.5-5 mg
Giới hạn trên: No established UL; 5 mg typically considered maximum
Liều lượng đã nghiên cứu
| Liều lượng | Thời gian | Hiệu quả | N |
|---|---|---|---|
| melatonin, light therapy, prescription medications (modafinil/armodafinil); optimized shift schedule | -- | Mixed | -- |
| 1.57 and 3.67 mM | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 1–10 mg | -- | Positive | -- |
| None | -- | Mixed | -- |
| Melatonin (various doses); light therapy; chronotherapy (various schedules) | -- | Positive | -- |
Thời điểm dùng tốt nhất: 30-60 minutes before bed
Safety & Side Effects
Tác dụng phụ đã được báo cáo
- ⚠ Daytime drowsiness
- ⚠ Headache
- ⚠ Dizziness
- ⚠ Nausea
- ⚠ Vivid dreams or nightmares
Tương tác đã biết
- ● Blood thinners (warfarin) — may increase bleeding risk
- ● Immunosuppressants — melatonin may stimulate immune function
- ● Diabetes medications — may affect blood sugar levels
- ● Sedatives and CNS depressants — additive drowsiness
Mức hấp thụ tối đa cho phép: No established UL; 5 mg typically considered maximum
Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
Frequently Asked Questions
Does Melatonin help with Rối Loạn Giấc Ngủ Do Làm Việc Ca?
Based on 51 studies with 1,903 participants, there is strong evidence from multiple clinical trials that Melatonin may support Rối Loạn Giấc Ngủ Do Làm Việc Ca management. Our evidence grade is A (Strong Evidence).
How much Melatonin should I take for Rối Loạn Giấc Ngủ Do Làm Việc Ca?
Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Melatonin?
Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Melatonin and Rối Loạn Giấc Ngủ Do Làm Việc Ca?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 51 peer-reviewed studies with 1,903 total participants. The overall direction of effect is positive.
Related Evidence
Các thành phần khác cho Rối Loạn Giấc Ngủ Do Làm Việc Ca
Melatonin cho các tình trạng khác
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