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Melatonin para Trastorno del Sueño por Trabajo por Turnos

A Evidencia Múltiples ensayos clínicos de gran tamaño muestran de forma consistente beneficios significativos.

Basado en 33 estudios (4 meta-analyses, 2 RCTs) con 1,917 participantes en total. 19/33 estudios muestran efectos positivos.

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A

Conclusión

Melatonin may help shift workers get better sleep by supporting the body's adjustment to irregular schedules, though results can vary from person to person.

  • 33 studies including 4 meta-analyses and 2 RCTs examine this use
  • 58% of studies show positive effects for shift work sleep problems
  • Systematic reviews of healthcare workers specifically support melatonin use
  • Strategic timing of melatonin around desired sleep periods may improve effectiveness

Key Study Findings

review
Shift work sleep disorder.
Dose: melatonin, light therapy, prescription medications (modafinil/armodafinil); optimized shift schedule vs: Placebo Efecto: None None
In Vitro
Exogenous L-Cysteine and Its Transport Through CtaP Play a Role in Biofilm Formation, Swimming Motility, …
Dose: 1.57 and 3.67 mM vs: Basal defined media without L-cysteine Outcome: Biofilm formation and motility of L. monocytogenes Efecto: None None

Población: Listeria monocytogenes 10403S and ctaP mutant

Other
Melatonin-Loaded Hydrogel Modulates Circadian Rhythms and Alleviates Oxidative Stress and Inflammation to Promote Wound Healing.
Dose: None vs: Wounds without hydrogel Outcome: Wound healing and circadian rhythm modulation Efecto: None None

Población: Animal wound model with circadian disruption

Review
Circadian rhythms and breast cancer: from molecular level to therapeutic advancements.
Dose: None vs: None Outcome: Inflammatory markers Efecto: None None

Población: Cancer patients

Other
Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice.
Dose: None vs: None Outcome: Fibrosis markers Efecto: None None

Población: Mouse model

systematic review
The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A …
Dose: 1–10 mg vs: Placebo Efecto: None None

Key Statistics

51

Estudios

1903

Participantes

Positive

A

Calificación

Referenced Papers

Handbook of clinical … 2025 10 citas
Current neuropharmacology 2022 40 citas
Journal of environmental … 2022 9 citas
Chronobiology international 2021 47 citas
Sexual medicine reviews 2018 74 citas
Current biology : … 2017 455 citas
Diabetes, obesity & … 2015 132 citas
Sleep medicine clinics 2015 75 citas
Pathologie-biologie 2014 467 citas
Continuum (Minneapolis, Minn.) 2013 172 citas
Methods in molecular … 2013
Nihon rinsho. Japanese … 2013
Postgraduate medicine 2011
Journal of pineal … 2011
The International journal … 2010 55 citas
Current treatment options … 2010
Tidsskrift for den … 2009 6 citas
Arzneimittel-Forschung 2008 89 citas
Cellular and molecular … 2007 88 citas
The FEBS journal 2006 56 citas
Tidsskrift for den … 2006
Bulletin de l'Academie … 2005
Experimental gerontology 2001 178 citas
Novartis Foundation symposium 2000 47 citas
Current treatment options … 1999 23 citas
Postgraduate medical journal 1998 17 citas
Journal of biological … 1997 255 citas
Duodecim; laaketieteellinen aikakauskirja 1991

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

general:
0.5-3 mg, 30-60 min before bed
jetlag:
0.5-5 mg

Límite superior: No established UL; 5 mg typically considered maximum

Dosificaciones estudiadas en la investigación

Dosificación Duración Efecto N
melatonin, light therapy, prescription medications (modafinil/armodafinil); optimized shift schedule -- Mixed --
1.57 and 3.67 mM -- Mixed --
None -- Positive --
None -- Positive --
None -- Positive --
1–10 mg -- Positive --
None -- Mixed --
Melatonin (various doses); light therapy; chronotherapy (various schedules) -- Positive --

Mejor momento para tomar: 30-60 minutes before bed

Safety & Side Effects

Efectos secundarios reportados

  • Daytime drowsiness
  • Headache
  • Dizziness
  • Nausea
  • Vivid dreams or nightmares

Interacciones conocidas

  • Blood thinners (warfarin) — may increase bleeding risk
  • Immunosuppressants — melatonin may stimulate immune function
  • Diabetes medications — may affect blood sugar levels
  • Sedatives and CNS depressants — additive drowsiness

Ingesta máxima tolerable: No established UL; 5 mg typically considered maximum

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Melatonin help with Trastorno del Sueño por Trabajo por Turnos?
Based on 51 studies with 1,903 participants, there is strong evidence from multiple clinical trials that Melatonin may support Trastorno del Sueño por Trabajo por Turnos management. Our evidence grade is A (Strong Evidence).
How much Melatonin should I take for Trastorno del Sueño por Trabajo por Turnos?
Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Melatonin?
Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Melatonin and Trastorno del Sueño por Trabajo por Turnos?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 51 peer-reviewed studies with 1,903 total participants. The overall direction of effect is positive.

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Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.