멜라토닌 관련 교대근무 수면장애

총 1,917명의 참여자를 대상으로 한 33건의 연구(메타분석 4건, RCT 2건)에 근거합니다. 33건 중 19건의 연구에서 긍정적인 효과가 나타났습니다.

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결론

Melatonin may help shift workers get better sleep by supporting the body's adjustment to irregular schedules, though results can vary from person to person.

33 studies including 4 meta-analyses and 2 RCTs examine this use
58% of studies show positive effects for shift work sleep problems
Systematic reviews of healthcare workers specifically support melatonin use
Strategic timing of melatonin around desired sleep periods may improve effectiveness

Key Study Findings

review

Shift work sleep disorder.

Dose: melatonin, light therapy, prescription medications (modafinil/armodafinil); optimized shift schedule vs: Placebo 효과: None None

In Vitro

Exogenous L-Cysteine and Its Transport Through CtaP Play a Role in Biofilm Formation, Swimming Motility, …

Dose: 1.57 and 3.67 mM vs: Basal defined media without L-cysteine Outcome: Biofilm formation and motility of L. monocytogenes 효과: None None

대상 집단: Listeria monocytogenes 10403S and ctaP mutant

Other

Melatonin-Loaded Hydrogel Modulates Circadian Rhythms and Alleviates Oxidative Stress and Inflammation to Promote Wound Healing.

Dose: None vs: Wounds without hydrogel Outcome: Wound healing and circadian rhythm modulation 효과: None None

대상 집단: Animal wound model with circadian disruption

Review

Circadian rhythms and breast cancer: from molecular level to therapeutic advancements.

Dose: None vs: None Outcome: Inflammatory markers 효과: None None

대상 집단: Cancer patients

Other

Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice.

Dose: None vs: None Outcome: Fibrosis markers 효과: None None

대상 집단: Mouse model

systematic review

The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A …

Dose: 1–10 mg vs: Placebo 효과: None None

Key Statistics

연구

1903

참여자

↑

Positive

등급

Referenced Papers

Shift work sleep disorder. Review

Handbook of clinical … 2025 10 인용

Melatonin-Loaded Hydrogel Modulates Circadian Rhythms and Alleviates Oxidative Stress and Inflammation to Promote Wound Healing. Other

ACS applied bio … 2025 4 인용

Exogenous L-Cysteine and Its Transport Through CtaP Play a Role in Biofilm Formation, Swimming Motility, and Swarming Motility of Listeria … Other

Foods (Basel, Switzerland) 2025 1 인용

Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes. Review

Diabetes & metabolism … 2024 18 인용

Circadian rhythms and breast cancer: from molecular level to therapeutic advancements. Review

Journal of cancer … 2024 11 인용

Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice. Other

Journal of pineal … 2024 9 인용

Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism. Review

International journal of … 2023 146 인용

Treatment of Circadian Rhythm Sleep-Wake Disorders. Review

Current neuropharmacology 2022 40 인용

The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review. Systematic Review

International journal of … 2022 25 인용

Is Shift Work Sleep Disorder a Risk Factor for Metabolic Syndrome and Its Components? A Systematic Review of Cross-Sectional Studies. Systematic Review

Metabolic syndrome and … 2022 16 인용

Melatonin: A Potential Antineoplastic Agent in Breast Cancer. Review

Journal of environmental … 2022 9 인용

Culture media, DMSO and efflux affect the antibacterial activity of cisplatin and oxaliplatin. Other

Letters in applied … 2022 7 인용

Methods to Assess Melatonin Receptor-Mediated Phase-Shift and Re-entrainment of Rhythmic Behaviors in Mouse Models. Other

Methods in molecular … 2022 1 인용

Circadian Rhythm Sleep-Wake Disorders: a Contemporary Review of Neurobiology, Treatment, and Dysregulation in Neurodegenerative Disease. Review

Neurotherapeutics : the … 2021 73 인용

Evening wear of blue-blocking glasses for sleep and mood disorders: a systematic review. Systematic Review

Chronobiology international 2021 47 인용

Circadian Rhythm Disorders and Corresponding Functional Brain Abnormalities in Young Female Nurses: A Preliminary Study. Other

Frontiers in neurology 2021 16 인용

The Potential Oncostatic Effects of Melatonin against Prostate Cancer. Review

Critical reviews in … 2021 3 인용

Novel Approaches for Assessing Circadian Rhythmicity in Humans: A Review. Review

Journal of biological … 2020 110 인용

Structural basis of ligand recognition at the human MT1 melatonin receptor. Other

Nature 2019 186 인용

Resetting the late timing of 'night owls' has a positive impact on mental health and performance. RCT

Sleep medicine 2019 102 인용

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. Review

British journal of … 2018 685 인용

The Relationship Between Shift Work and Men's Health. Review

Sexual medicine reviews 2018 74 인용

The use and misuse of exogenous melatonin in the treatment of sleep disorders. Review

Current opinion in … 2018 29 인용

Meal Timing Regulates the Human Circadian System. Other

Current biology : … 2017 455 인용

Chronomedicine and type 2 diabetes: shining some light on melatonin. Review

Diabetologia 2017 71 인용

Melatonin restores hippocampal neural precursor cell proliferation and prevents cognitive deficits induced by jet lag simulation in adult mice. Other

Journal of pineal … 2017 45 인용

Sleep Disorders: Circadian Rhythm Sleep-Wake Disorders. Review

FP essentials 2017 15 인용

Keeping circadian time with hormones. Review

Diabetes, obesity & … 2015 132 인용

Pharmacological interventions for sleepiness and sleep disturbances caused by shift work. Other

Sao Paulo medical … 2015 131 인용

Jet Lag and Shift Work Disorder. Review

Sleep medicine clinics 2015 75 인용

Short-term incubation of bovine placentome sections as a tool to study xenobiotic mechanism of action. Other

Reproductive biology 2015 6 인용

Impacts of shift work on sleep and circadian rhythms. Review

Pathologie-biologie 2014 467 인용

Pharmacological interventions for sleepiness and sleep disturbances caused by shift work. Meta-Analysis

The Cochrane database … 2014 131 인용

Circadian rhythm abnormalities. Case Report

Continuum (Minneapolis, Minn.) 2013 172 인용

Measurement of melatonin and 6-sulphatoxymelatonin. Other

Methods in molecular … 2013

[Circadian rhythm sleep disorder]. Review

Nihon rinsho. Japanese … 2013

Shift work disorder case studies: applying management principles in clinical practice. Case Report

The Journal of … 2012

Jet lag and shift work sleep disorders: how to help reset the internal clock. Review

Cleveland Clinic journal … 2011 73 인용

Understanding and diagnosing shift work disorder. Review

Postgraduate medicine 2011

Update on the use of melatonin in pediatrics. Review

Journal of pineal … 2011

Melatonin: pharmacological aspects and clinical trends. Review

The International journal … 2010 55 인용

Ready for takeoff? A critical review of armodafinil and modafinil for the treatment of sleepiness associated with jet lag. Other

Nature and science … 2010 3 인용

Treatment of shift work disorder and jet lag. Other

Current treatment options … 2010

Complementary and alternative medicine usage for behavioral health indications. Review

Primary care 2010

[Circadian rhythm sleep disorders]. Review

Tidsskrift for den … 2009 6 인용

Tasimelteon, a melatonin agonist for the treatment of insomnia and circadian rhythm sleep disorders. Other

Current opinion in … 2009

The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders. Review

Nature clinical practice. … 2008 139 인용

Melatonergic drugs in clinical practice. Review

Arzneimittel-Forschung 2008 89 인용

Jet lag: therapeutic use of melatonin and possible application of melatonin analogs. Review

Travel medicine and … 2008 84 인용

A clinical approach to circadian rhythm sleep disorders. Review

Sleep medicine 2007 201 인용

Chronobiology of sleep in humans. Review

Cellular and molecular … 2007 88 인용

Circadian rhythmicity and the pharmacologic management of insomnia. Review

The American journal … 2007 3 인용

Circadian rhythm sleep disorders: part I, basic principles, shift work and jet lag disorders. An American Academy of Sleep Medicine … Review

Sleep 2007

Neurobiological effects of melatonin as related to cancer. Review

European journal of … 2007

Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. An American Academy of Sleep Medicine report. Review

Sleep 2007

Shift work sleep disorder: burden of illness and approaches to management. Review

Drugs 2006 110 인용

Melatonin: Nature's most versatile biological signal? Review

The FEBS journal 2006 56 인용

[Rhythms, depressions and light]. Review

Tidsskrift for den … 2006

The human circadian system in normal and disordered sleep. Review

The Journal of … 2005

[Melatonin: what for?]. Review

Bulletin de l'Academie … 2005

Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists. Review

Sleep medicine 2004

Human aging and melatonin. Clinical relevance. Review

Experimental gerontology 2001 178 인용

Circadian rhythm sleep disorders: pathophysiology and potential approaches to management. Review

CNS drugs 2001 135 인용

Pathophysiology of human circadian rhythms. Review

Novartis Foundation symposium 2000 47 인용

Circadian Rhythm Sleep Disorders. Other

Current treatment options … 1999 23 인용

Use of melatonin in the treatment of phase shift and sleep disorders. Review

Advances in experimental … 1999

Jet-lag and shift work: (2). Therapeutic use of melatonin. Review

Journal of the … 1999

Melatonin and the pineal gland: influence on mammalian seasonal and circadian physiology. Other

Reviews of reproduction 1998 381 인용

Disorders of the sleep-wake cycle in adults. Review

Postgraduate medical journal 1998 17 인용

Efficacy of melatonin treatment in jet lag, shift work, and blindness. Review

Journal of biological … 1997 255 인용

Melatonin: a master hormone and a candidate for universal panacea. Review

Indian journal of … 1996

[Shift work, jet lag and sleep]. Review

Duodecim; laaketieteellinen aikakauskirja 1991

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

일반적으로 사용되는 용량

general:: 0.5-3 mg, 30-60 min before bed
jetlag:: 0.5-5 mg

상한량: No established UL; 5 mg typically considered maximum

연구에서 사용된 용량

용량	기간	효과	N
melatonin, light therapy, prescription medications (modafinil/armodafinil); optimized shift schedule	--	Mixed	--
1.57 and 3.67 mM	--	Mixed	--
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
1–10 mg	--	Positive	--
None	--	Mixed	--
Melatonin (various doses); light therapy; chronotherapy (various schedules)	--	Positive	--

권장 복용 시간: 30-60 minutes before bed

Safety & Side Effects

보고된 부작용

⚠ Daytime drowsiness
⚠ Headache
⚠ Dizziness
⚠ Nausea
⚠ Vivid dreams or nightmares

알려진 상호작용

● Blood thinners (warfarin) — may increase bleeding risk
● Immunosuppressants — melatonin may stimulate immune function
● Diabetes medications — may affect blood sugar levels
● Sedatives and CNS depressants — additive drowsiness

일일 최대 섭취 허용량: No established UL; 5 mg typically considered maximum

건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.

Frequently Asked Questions

Does 멜라토닌 help with 교대근무 수면장애?

Based on 51 studies with 1,903 participants, there is strong evidence from multiple clinical trials that 멜라토닌 may support 교대근무 수면장애 management. Our evidence grade is A (Strong Evidence).

How much 멜라토닌 should I take for 교대근무 수면장애?

Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of 멜라토닌?

Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for 멜라토닌 and 교대근무 수면장애?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 51 peer-reviewed studies with 1,903 total participants. The overall direction of effect is positive.

Related Evidence

멜라토닌 다른 건강 상태에 대한 근거

불면증 A 일주기 리듬 장애 A 시차증(제트래그) A 수면 개시 장애 A 노화에 따른 수면 변화 B

한눈에 보기

총 1,917명의 참여자를 대상으로 한 33건의 연구(메타분석 4건, RCT 2건)에 근거합니다. 33건 중 19건의 연구에서 긍정적인 효과가 나타났습니다.

Evidence Strength92%

High confidence

연구 분석

RCT (1)Meta (1)Other (49)

대안 비교

이 건강 상태에 대한 다른 성분의 비교 결과를 확인하세요.

모든 성분 보기: 교대근무 수면장애

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FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.