L-Ornithine 用于 轮班工作睡眠障碍
C 证据 来自小型研究的证据有限，但存在一些积极信号。基于3项研究（2项RCT）。3项中有2项显示积极效果。
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C
结论
基于3项研究（2项RCT）。3项中有2项显示积极效果。
Key Study Findings
Randomized Controlled Trial
1.0 weeks
Double-blind
A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the …
Dose: 400 mg
vs: Placebo
Outcome: Circadian rhythm parameters
效果: None
None
研究人群: Healthy adults
Randomized Controlled Trial
8.0 weeks
Double-blind
Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in …
Dose: 400 mg/day
vs: placebo
Outcome: None
效果: None
None
研究人群: healthy subjects
Review
Strategies of Functional Foods Promote Sleep in Human Being.
Dose: None
vs: None
Outcome: Sleep quality and insomnia prevention
效果: None
None
研究人群: Adults with insomnia or sleep disorders
Key Statistics
3
研究数量
--
受试者
↑
Positive
C
等级
Referenced Papers
Chronobiology international
2018
13 次引用
Nutrition journal
2014
76 次引用
Current signal transduction …
2014
41 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- sleep:
- 400-800 mg, 30-60 min before bed
上限： Not formally established; 6,000 mg/day used in exercise studies
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| 400 mg | 1.0 weeks | Mixed | -- |
| 400 mg/day | 8.0 weeks | Positive | -- |
| None | -- | Positive | -- |
最佳服用时间： 30-60 minutes before bed on an empty stomach
Safety & Side Effects
已报告的副作用
- ⚠ GI discomfort at high doses (diarrhea)
- ⚠ Insomnia at very high doses (paradoxical in some individuals)
已知相互作用
- ● Growth hormone secretagogues — ornithine may stimulate GH release
- ● Arginine supplements — metabolic interaction (urea cycle)
可耐受最高摄入量： Not formally established; 6,000 mg/day used in exercise studies
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does L-Ornithine help with 轮班工作睡眠障碍?
Based on 3 studies with 0 participants, there is limited but promising evidence that L-Ornithine may support 轮班工作睡眠障碍 management. Our evidence grade is C (Some Evidence).
How much L-Ornithine should I take for 轮班工作睡眠障碍?
Studies have used various dosages. A commonly studied range is 400-800 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Ornithine?
Reported side effects may include GI discomfort at high doses (diarrhea), Insomnia at very high doses (paradoxical in some individuals). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Ornithine and 轮班工作睡眠障碍?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 0 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 轮班工作睡眠障碍
L-Ornithine 用于其他健康状况
References
- [1] Takafumi Fukuda et al.. Chronobiol Int. 2018. A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock. doi:10.1080/07420528.2018.1490315 PubMed
- [2] Mika Miyake et al.. Nutr J. 2014. Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers. doi:10.1186/1475-2891-13-53 PubMed
- [3] Yawen Zeng et al.. Curr Signal Transduct Ther. 2014. Strategies of Functional Foods Promote Sleep in Human Being. doi:10.2174/1574362410666150205165504 PubMed
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