L-Ornithine لـ اضطراب نوم العمل بنظام الورديات

C الأدلة أدلة محدودة من دراسات صغيرة، غير أن ثمة بعض الإشارات الإيجابية.

Based on 3 studies (2 RCTs). 2/3 studies show positive effects.

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الخلاصة

Based on 3 studies (2 RCTs). 2/3 studies show positive effects.

Key Study Findings

Randomized Controlled Trial 1.0 weeks Double-blind

A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the …

Dose: 400 mg مقابل: Placebo Outcome: Circadian rhythm parameters التأثير: None None

المجتمع المدروس: Healthy adults

Randomized Controlled Trial 8.0 weeks Double-blind

Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in …

Dose: 400 mg/day مقابل: placebo Outcome: None التأثير: None None

المجتمع المدروس: healthy subjects

Review

Strategies of Functional Foods Promote Sleep in Human Being.

Dose: None مقابل: None Outcome: Sleep quality and insomnia prevention التأثير: None None

المجتمع المدروس: Adults with insomnia or sleep disorders

Key Statistics

الدراسات

المشاركون

↑

Positive

التقييم

Referenced Papers

A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock. RCT

Chronobiology international 2018 13 اقتباسات

Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers. RCT

Nutrition journal 2014 76 اقتباسات

Strategies of Functional Foods Promote Sleep in Human Being. Other

Current signal transduction … 2014 41 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

sleep:: 400-800 mg, 30-60 min before bed

الحد الأعلى: Not formally established; 6,000 mg/day used in exercise studies

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
400 mg	1.0 weeks	Mixed	--
400 mg/day	8.0 weeks	Positive	--
None	--	Positive	--

أفضل وقت للتناول: 30-60 minutes before bed on an empty stomach

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ GI discomfort at high doses (diarrhea)
⚠ Insomnia at very high doses (paradoxical in some individuals)

التفاعلات المعروفة

● Growth hormone secretagogues — ornithine may stimulate GH release
● Arginine supplements — metabolic interaction (urea cycle)

الحد الأقصى المسموح به: Not formally established; 6,000 mg/day used in exercise studies

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does L-Ornithine help with اضطراب نوم العمل بنظام الورديات?

Based on 3 studies with 0 participants, there is limited but promising evidence that L-Ornithine may support اضطراب نوم العمل بنظام الورديات management. Our evidence grade is C (Some Evidence).

How much L-Ornithine should I take for اضطراب نوم العمل بنظام الورديات?

Studies have used various dosages. A commonly studied range is 400-800 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of L-Ornithine?

Reported side effects may include GI discomfort at high doses (diarrhea), Insomnia at very high doses (paradoxical in some individuals). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for L-Ornithine and اضطراب نوم العمل بنظام الورديات?

We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 0 total participants. The overall direction of effect is positive.

مكونات أخرى لـ اضطراب نوم العمل بنظام الورديات

Melatonin A

L-Ornithine لحالات أخرى

الأرق C

References

[1] Takafumi Fukuda et al.. Chronobiol Int. 2018. A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock. doi:10.1080/07420528.2018.1490315 PubMed
[2] Mika Miyake et al.. Nutr J. 2014. Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers. doi:10.1186/1475-2891-13-53 PubMed
[3] Yawen Zeng et al.. Curr Signal Transduct Ther. 2014. Strategies of Functional Foods Promote Sleep in Human Being. doi:10.2174/1574362410666150205165504 PubMed

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