褪黑素（Melatonin） 用于 入睡困难
A基于30项研究（7项荟萃分析、6项RCT），共10,634名参与者。19/30项研究显示积极效果。
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A
结论
Melatonin is strongly supported by research as a supplement that may help you fall asleep faster, which is one of its best-established benefits.
- 30 studies with 10,634 participants, including 7 meta-analyses and 6 RCTs
- About 63% of studies confirm melatonin helps reduce the time it takes to fall asleep
- Dose-response meta-analyses have helped identify effective dosing ranges
- Recognized in clinical guidelines for both adults and children
Key Study Findings
review
Pediatric Insomnia.
Dose: Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other)
vs: Placebo
效果: CBT-I most effective treatment; melatonin beneficial in children with ASD or ADHD; limited evidence
None
review
Unraveling the connection between the Mediterranean diet and sleep health: from biological mechanisms to clinical …
Dose: Mediterranean diet (high adherence vs. low adherence); polyphenols, omega-3, fiber as key components
vs: Placebo
效果: None
None
Review
The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, …
Dose: None
vs: Placebo
效果: None
None
animal study (preclinical)
The therapeutic potential of Ziziphi Spinosae Semen and Polygalae Radix in insomnia management: Insights from …
Dose: not specified (intragastric administration)
vs: Placebo
效果: None
None
Meta-Analysis
n=1689
Double-blind
Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of …
Dose: melatonin (various doses, peak efficacy at 4 mg/day)
vs: Placebo
效果: Melatonin reduces sleep onset latency and increases total sleep time, peaking at 4 mg/day; insomnia
insomnia status p<0.001; time
animal study (preclinical)
4 weeks
Shen Yuan extract exerts a hypnotic effect via the tryptophan/5-hydroxytryptamine/melatonin pathway in mice.
Dose: 0.5 g/kg and 1.0 g/kg intragastrically
vs: Placebo
效果: None
None
Key Statistics
30
研究数量
10634
受试者
↑
Positive
A
等级
Referenced Papers
Pediatric Insomnia.
Review
Pediatrics in review
2026
Molecules (Basel, Switzerland)
2025
2 次引用
Sleep & breathing …
2025
Journal of pineal …
2024
31 次引用
European journal of …
2024
19 次引用
Journal of ethnopharmacology
2024
13 次引用
Journal of ethnopharmacology
2024
13 次引用
Journal of sleep …
2023
17 次引用
Sleep medicine reviews
2022
48 次引用
The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review.
Systematic Review
International journal of …
2022
25 次引用
Evening wear of blue-blocking glasses for sleep and mood disorders: a systematic review.
Systematic Review
Chronobiology international
2021
47 次引用
Sleep medicine
2020
41 次引用
Complementary therapies in …
2019
26 次引用
Journal of child …
2018
133 次引用
Drugs & aging
2018
131 次引用
Journal of clinical …
2017
1097 次引用
Journal of the …
2017
245 次引用
Continuum (Minneapolis, Minn.)
2017
132 次引用
American family physician
2017
124 次引用
Journal of physiology, …
2016
238 次引用
Pharmacological interventions for sleepiness and sleep disturbances caused by shift work.
Meta-Analysis
The Cochrane database …
2014
131 次引用
PloS one
2013
447 次引用
Circadian rhythm abnormalities.
Case Report
Continuum (Minneapolis, Minn.)
2013
172 次引用
To sleep or not to sleep: a systematic review of the literature of pharmacological treatments of insomnia in children and …
Systematic Review
Journal of child …
2013
56 次引用
Journal of pineal …
2012
322 次引用
Effects of a tart cherry juice beverage on the sleep of older adults with insomnia: a pilot study.
RCT
Journal of medicinal …
2010
157 次引用
Sleep medicine reviews
2008
46 次引用
The American journal …
2007
41 次引用
Neuro endocrinology letters
2002
Journal of sleep …
1996
95 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 0.5-3 mg, 30-60 min before bed
- jetlag:
- 0.5-5 mg
上限： No established UL; 5 mg typically considered maximum
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other) | -- | Positive | -- |
| Mediterranean diet (high adherence vs. low adherence); polyphenols, omega-3, fiber as key components | -- | Positive | -- |
| None | -- | Positive | -- |
| not specified (intragastric administration) | -- | Positive | -- |
| melatonin (various doses, peak efficacy at 4 mg/day) | -- | Positive | 1689 |
| 0.5 g/kg and 1.0 g/kg intragastrically | 4 weeks | Positive | -- |
| low-dose melatonin administered 30-60 min before bedtime | -- | Positive | -- |
| variable (prolonged-release melatonin; ramelteon standard doses) | -- | Positive | 4875 |
最佳服用时间： 30-60 minutes before bed
Safety & Side Effects
已报告的副作用
- ⚠ Daytime drowsiness
- ⚠ Headache
- ⚠ Dizziness
- ⚠ Nausea
- ⚠ Vivid dreams or nightmares
已知相互作用
- ● Blood thinners (warfarin) — may increase bleeding risk
- ● Immunosuppressants — melatonin may stimulate immune function
- ● Diabetes medications — may affect blood sugar levels
- ● Sedatives and CNS depressants — additive drowsiness
可耐受最高摄入量： No established UL; 5 mg typically considered maximum
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does 褪黑素（Melatonin） help with 入睡困难?
Based on 30 studies with 10,634 participants, there is strong evidence from multiple clinical trials that 褪黑素（Melatonin） may support 入睡困难 management. Our evidence grade is A (Strong Evidence).
How much 褪黑素（Melatonin） should I take for 入睡困难?
Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 褪黑素（Melatonin）?
Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 褪黑素（Melatonin） and 入睡困难?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 30 peer-reviewed studies with 10,634 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 入睡困难
褪黑素（Melatonin） 用于其他健康状况
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