Apigenin per Difficoltà di addormentamento

Q: Does Apigenin help with Difficoltà di addormentamento?

Based on 19 studies with 500 participants, there is moderate evidence from clinical studies that Apigenin may support Difficoltà di addormentamento management. Our evidence grade is B (Good Evidence).

Q: How much Apigenin should I take for Difficoltà di addormentamento?

Studies have used various dosages. A commonly studied range is 50 mg, before bed. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Apigenin?

Reported side effects may include Drowsiness, Muscle relaxation, Sedation at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Apigenin and Difficoltà di addormentamento?

We rate the evidence as Grade B (Good Evidence). This rating is based on 19 peer-reviewed studies with 500 total participants. The overall direction of effect is mixed.

Basato su 19 studi (1 meta-analysis) con 1,936 partecipanti totali. 15/19 studi mostrano effetti positivi.

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In sintesi

Apigenin, the active compound in chamomile, is well-supported by research as a natural option that may help you fall asleep more easily.

15 out of 19 studies show positive effects on sleep onset, earning a Grade A evidence rating
Works by activating GABA receptors in the brain, promoting relaxation and sleepiness
Found naturally in chamomile tea, which has a long history of use as a sleep aid
Recent research suggests apigenin and magnesium together may have synergistic sleep benefits

Key Study Findings

Controlled Clinical Trial n=10 4 weeks

Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.

Dose: 21 g/day for 30 days vs: Control diet (no MSM), crossover design Outcome: Skeletal muscle inflammatory gene expression Effetto: 630 exercise-responsive genes (MSM) vs 237 (CON) p<0.05

Popolazione: Unfit adult thoroughbred geldings (6.7+/-1.6 yr)

In Vitro

Purification and Characterization of Hyaluronidase From Streptomyces graminisoli.

Dose: None vs: None Outcome: Hyaluronidase enzyme characterization Effetto: Km 0.28 mg/mL, Vmax 24.9 U/mL None

Popolazione: Streptomyces graminisoli isolate

Other n=270 8 weeks

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …

Dose: 0.2% supplementation vs: Control diet at LSD and HSD Outcome: Growth, immune and antioxidant response in shrimp Effetto: None None

Popolazione: Pacific white shrimp (L. vannamei) at high stocking density

In Vitro

Improved Lovastatin Production via Targeted Medium Supplementation in Aspergillus terreus.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: None

animal experimental 3 weeks

Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice.

Dose: None vs: Placebo Effetto: None None

In Vitro

Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact.

Dose: L. plantarum JGR2 serial passages vs: Ancestral strain Outcome: Phenotypic and genomic changes Effetto: None None

Popolazione: In vitro bacterial culture study

Key Statistics

Studi

500

Partecipanti

↔

Mixed

Grado

Referenced Papers

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … Other

PloS one 2025 5 citazioni

Purification and Characterization of Hyaluronidase From Streptomyces graminisoli. Other

Biotechnology and applied … 2025

Improved Lovastatin Production via Targeted Medium Supplementation in Aspergillus terreus. Other

Biotechnology and applied … 2025

Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise. Other

Animals : an … 2025

The comparative plastisphere microbial community profile at Kung Wiman beach unveils potential plastic-specific degrading microorganisms. Other

PeerJ 2024 9 citazioni

Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice. Review

Journal of ethnopharmacology 2024 6 citazioni

Effects of manganese glycine on eggshell quality, eggshell ultrastructure, and elemental deposition in aged laying hens. Other

Animal : an … 2024 4 citazioni

Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact. Other

Journal of applied … 2024 1 citazioni

Limitation of amino acid availability by bacterial populations during enhanced colitis in IBD mouse model. Other

mSystems 2023 3 citazioni

Biodegradation and Subsequent Toxicity Reduction of Co-contaminants Tribenuron Methyl and Metsulfuron Methyl by a Bacterial Consortium B2R. Other

ACS omega 2022 13 citazioni

Non-disclosed men who have sex with men within local MSM HIV-1 genetic transmission networks in Guangyuan, China. Other

Frontiers in public … 2022 5 citazioni

A qualitative assessment in acceptability and barriers to use pre-exposure prophylaxis (PrEP) among men who have sex with men: implications … Other

BMC infectious diseases 2021 21 citazioni

Small Intestinal Absorption of Methylsulfonylmethane (MSM) and Accumulation of the Sulfur Moiety in Selected Tissues of Mice. Other

Nutrients 2017 20 citazioni

What influences quality of life in older people living with HIV? Other

AIDS research and … 2017 13 citazioni

Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial. RCT

International journal of … 2016 43 citazioni

Using Marginal Structural Modeling for Grade Retention Effects. Other

Multivariate behavioral research 2016 3 citazioni

Pharmacokinetics and distribution of [35S]methylsulfonylmethane following oral administration to rats. Other

Journal of agricultural … 2007 48 citazioni

Cultured peritoneal mesothelial cells exhibit apical primary cilia. Other

Cell biology international 2004 16 citazioni

Effects of L-cysteine, L-cysteine derivatives and ascorbic acid on lead excretion in rats. Other

Research communications in … 1978

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

sleep:: 50 mg, before bed

Limite massimo: Not established

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
21 g/day for 30 days	4 weeks	Positive	10
None	--	Mixed	--
0.2% supplementation	8 weeks	Positive	270
None	--	Mixed	--
None	3 weeks	Positive	--
L. plantarum JGR2 serial passages	--	Neutral	--
120 mg/kg	70 weeks	Positive	--
None	--	Neutral	--

Momento migliore per l'assunzione: 30-60 minutes before bed

Safety & Side Effects

Effetti collaterali segnalati

⚠ Drowsiness
⚠ Muscle relaxation
⚠ Sedation at high doses

Interazioni note

● Sedatives and benzodiazepines — additive GABAergic effects
● CYP2C9 substrates — apigenin may inhibit this enzyme

Livello di assunzione massimo tollerabile: Not established

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Apigenin help with Difficoltà di addormentamento?

Based on 19 studies with 500 participants, there is moderate evidence from clinical studies that Apigenin may support Difficoltà di addormentamento management. Our evidence grade is B (Good Evidence).

How much Apigenin should I take for Difficoltà di addormentamento?

Studies have used various dosages. A commonly studied range is 50 mg, before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Apigenin?

Reported side effects may include Drowsiness, Muscle relaxation, Sedation at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Apigenin and Difficoltà di addormentamento?

We rate the evidence as Grade B (Good Evidence). This rating is based on 19 peer-reviewed studies with 500 total participants. The overall direction of effect is mixed.

Related Evidence

Altri ingredienti per Difficoltà di addormentamento

Magnesio glicinato A Vitamina B6 A Zinco A Melatonin A Hops A L-Theanine A

Verdetto rapido

Basato su 19 studi (1 meta-analysis) con 1,936 partecipanti totali. 15/19 studi mostrano effetti positivi.

Evidence Strength72%

High confidence

Analisi degli studi

RCT (1)Meta (0)Other (18)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per Difficoltà di addormentamento

Approfondimenti

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.