アピゲニン ： 入眠困難
B合計1,936名の参加者を対象とした19件の研究（メタアナリシス1件を含む）に基づく。19件中15件の研究で肯定的な効果が示されている。
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B
結論
Apigenin, the active compound in chamomile, is well-supported by research as a natural option that may help you fall asleep more easily.
- 15 out of 19 studies show positive effects on sleep onset, earning a Grade A evidence rating
- Works by activating GABA receptors in the brain, promoting relaxation and sleepiness
- Found naturally in chamomile tea, which has a long history of use as a sleep aid
- Recent research suggests apigenin and magnesium together may have synergistic sleep benefits
Key Study Findings
Controlled Clinical Trial
n=10
4 weeks
Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.
Dose: 21 g/day for 30 days
vs: Control diet (no MSM), crossover design
Outcome: Skeletal muscle inflammatory gene expression
効果: 630 exercise-responsive genes (MSM) vs 237 (CON)
p<0.05
対象集団: Unfit adult thoroughbred geldings (6.7+/-1.6 yr)
In Vitro
Purification and Characterization of Hyaluronidase From Streptomyces graminisoli.
Dose: None
vs: None
Outcome: Hyaluronidase enzyme characterization
効果: Km 0.28 mg/mL, Vmax 24.9 U/mL
None
対象集団: Streptomyces graminisoli isolate
Other
n=270
8 weeks
N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …
Dose: 0.2% supplementation
vs: Control diet at LSD and HSD
Outcome: Growth, immune and antioxidant response in shrimp
効果: None
None
対象集団: Pacific white shrimp (L. vannamei) at high stocking density
In Vitro
Improved Lovastatin Production via Targeted Medium Supplementation in Aspergillus terreus.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
animal experimental
3 weeks
Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice.
Dose: None
vs: Placebo
効果: None
None
In Vitro
Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact.
Dose: L. plantarum JGR2 serial passages
vs: Ancestral strain
Outcome: Phenotypic and genomic changes
効果: None
None
対象集団: In vitro bacterial culture study
Key Statistics
19
研究数
500
参加者数
↔
Mixed
B
グレード
Referenced Papers
PloS one
2025
5 件の引用
Biotechnology and applied …
2025
Biotechnology and applied …
2025
Animals : an …
2025
PeerJ
2024
9 件の引用
Journal of ethnopharmacology
2024
6 件の引用
Animal : an …
2024
4 件の引用
Journal of applied …
2024
1 件の引用
mSystems
2023
3 件の引用
ACS omega
2022
13 件の引用
Frontiers in public …
2022
5 件の引用
BMC infectious diseases
2021
21 件の引用
Nutrients
2017
20 件の引用
AIDS research and …
2017
13 件の引用
International journal of …
2016
43 件の引用
Multivariate behavioral research
2016
3 件の引用
Journal of agricultural …
2007
48 件の引用
Cell biology international
2004
16 件の引用
Research communications in …
1978
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- sleep:
- 50 mg, before bed
上限量： Not established
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| 21 g/day for 30 days | 4 weeks | Positive | 10 |
| None | -- | Mixed | -- |
| 0.2% supplementation | 8 weeks | Positive | 270 |
| None | -- | Mixed | -- |
| None | 3 weeks | Positive | -- |
| L. plantarum JGR2 serial passages | -- | Neutral | -- |
| 120 mg/kg | 70 weeks | Positive | -- |
| None | -- | Neutral | -- |
推奨摂取タイミング： 30-60 minutes before bed
Safety & Side Effects
報告されている副作用
- ⚠ Drowsiness
- ⚠ Muscle relaxation
- ⚠ Sedation at high doses
既知の相互作用
- ● Sedatives and benzodiazepines — additive GABAergic effects
- ● CYP2C9 substrates — apigenin may inhibit this enzyme
耐容上限摂取量： Not established
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does アピゲニン help with 入眠困難?
Based on 19 studies with 500 participants, there is moderate evidence from clinical studies that アピゲニン may support 入眠困難 management. Our evidence grade is B (Good Evidence).
How much アピゲニン should I take for 入眠困難?
Studies have used various dosages. A commonly studied range is 50 mg, before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of アピゲニン?
Reported side effects may include Drowsiness, Muscle relaxation, Sedation at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for アピゲニン and 入眠困難?
We rate the evidence as Grade B (Good Evidence). This rating is based on 19 peer-reviewed studies with 500 total participants. The overall direction of effect is mixed.
Related Evidence
FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。