What is the recommended dosage for Skullcap?

Sleep: 350-500 mg dried herb or 1-2 mL tincture, before bed

What are the side effects of Skullcap?

Potential side effects include: Drowsiness (intended effect), Rare hepatotoxicity (usually from adulterated products), GI discomfort.

What is skullcap and can it help with sleep anxiety?

American skullcap (Scutellaria lateriflora) is a mint-family herb traditionally used as a nervine (nerve-calming agent). Its flavonoids, including baicalin and scutellarein, may modulate GABA-A receptors, which are the same receptors targeted by benzodiazepines. A small double-blind study found anxiolytic effects without significant sedation. Note: American skullcap differs from Chinese skullcap (S. baicalensis). Clinical evidence for sleep is very preliminary. Consult your healthcare provider.

Which type of skullcap is used for sleep support?

Two distinct species are sold as 'skullcap': American skullcap (Scutellaria lateriflora) and Chinese skullcap (Scutellaria baicalensis), with quite different active compounds and traditional uses. American skullcap is the species traditionally used for sleep and anxiety support — it contains flavonoids like baicalin, scutellarein, and lateriflorin that may modulate GABA-A receptors. Chinese skullcap (Huang Qin) is primarily used for inflammation and immune support. When selecting a supplement for sleep, look specifically for Scutellaria lateriflora rather than S. baicalensis.

What does the research say about skullcap for anxiety and sleep?

The clinical evidence for American skullcap is limited but encouraging. A double-blind crossover study with 43 participants found that 350 mg of freeze-dried skullcap extract significantly reduced anxiety scores compared to placebo, with effects noted within 30 minutes. However, large-scale clinical trials specifically measuring sleep outcomes are lacking. The existing evidence primarily comes from traditional use reports, small clinical studies, and preclinical research showing GABAergic activity. Research suggests skullcap may be most helpful for sleep difficulties related to anxiety or racing thoughts at bedtime.

Skullcap

herb

Also known as: Scutellaria lateriflora, American skullcap, Blue skullcap, Mad dog skullcap

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About

American skullcap (Scutellaria lateriflora) contains baicalin and scutellarein, flavonoids that bind GABA-A receptors and demonstrate anxiolytic properties. A small double-blind study found it significantly reduced anxiety compared to placebo. Its calming effects may support sleep onset in anxious individuals.

How It Works

Baicalin and scutellarein bind GABA-A receptor benzodiazepine site; flavonoids inhibit glutamate release; antioxidant and anti-inflammatory neuroprotective effects.

Evidence For Conditions

Condition	Grade	Studies	Participants
Anxiety-Related Sleep Problems	B	2	--	View →
Hyperarousal and Cognitive Insomnia	B	2	--	View →

Side Effects

Drowsiness (intended effect)
Rare hepatotoxicity (usually from adulterated products)
GI discomfort

Drug & Supplement Interactions

Sedatives and benzodiazepines — additive CNS depression
Hepatotoxic medications — potential additive liver stress
Anticonvulsants — may alter seizure threshold

Always inform your healthcare provider about all supplements you take.

Related Ingredients

California Poppy Chamomile Hops Jujube Seed Extract Kava

Quick Facts

Dosage: Sleep: 350-500 mg dried herb or 1-2 mL tincture, before bed
Forms: capsule tincture tea
Natural Sources: Skullcap aerial parts
Upper Limit: Not formally established
Best Time: 30-60 minutes before bed

Evidence Summary

Anxiety-Related Sleep Problems B

Hyperarousal and Cognitive Insomnia B

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.