Skullcap for Hyperarousal and Cognitive Insomnia

Based on 2 studies (1 meta-analysis). 2/2 studies show positive effects.

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The Bottom Line

Based on 2 studies (1 meta-analysis). 2/2 studies show positive effects.

Key Statistics

Studies

Participants

↑

Positive

Grade

Referenced Papers

GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Systematic Review

Phytotherapy research : … 2018 95 citations

Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. Review

Medical science monitor … 2009 85 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Commonly Used Dosages

sleep:: 350-500 mg dried herb or 1-2 mL tincture, before bed

Upper limit: Not formally established

Best taken: 30-60 minutes before bed

Safety & Side Effects

Reported Side Effects

⚠ Drowsiness (intended effect)
⚠ Rare hepatotoxicity (usually from adulterated products)
⚠ GI discomfort

Known Interactions

● Sedatives and benzodiazepines — additive CNS depression
● Hepatotoxic medications — potential additive liver stress
● Anticonvulsants — may alter seizure threshold

Tolerable upper intake: Not formally established

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does Skullcap help with Hyperarousal and Cognitive Insomnia?

Based on 2 studies with 0 participants, there is moderate evidence from clinical studies that Skullcap may support Hyperarousal and Cognitive Insomnia management. Our evidence grade is B (Good Evidence).

How much Skullcap should I take for Hyperarousal and Cognitive Insomnia?

Studies have used various dosages. A commonly studied range is 350-500 mg dried herb or 1-2 mL tincture, before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Skullcap?

Reported side effects may include Drowsiness (intended effect), Rare hepatotoxicity (usually from adulterated products), GI discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Skullcap and Hyperarousal and Cognitive Insomnia?

We rate the evidence as Grade B (Good Evidence). This rating is based on 2 peer-reviewed studies with 0 total participants. The overall direction of effect is positive.

Related Evidence

Other ingredients for Hyperarousal and Cognitive Insomnia

Kava A Magnesium L-Threonate D

Skullcap for other conditions

Anxiety-Related Sleep Problems B

Quick Verdict

Based on 2 studies (1 meta-analysis). 2/2 studies show positive effects.

Evidence Strength72%

High confidence

Study Breakdown

RCT (0)Meta (0)Other (2)

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FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.