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فيتامين B6 لـ الأرق

B

بناءً على 5 دراسة (1 RCT) بمشاركة 50 مشاركًا إجمالاً. 3/5 دراسة تُظهر تأثيرات إيجابية.

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B

الخلاصة

Vitamin B6 may play a role in supporting sleep through its involvement in melatonin production, but the direct evidence for insomnia is limited and preliminary.

  • Only 5 studies with 50 total participants — evidence is preliminary
  • B6 is involved in producing serotonin and melatonin, both important for sleep
  • Genetic studies (Mendelian randomization) suggest a link between B6 and sleep behaviors
  • More clinical trials with larger sample sizes are needed

Key Study Findings

Other
Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study.
Dose: None مقابل: None Outcome: Causal association of nutrients with insomnia التأثير: Magnesium OR 0.869 (95% CI 0.763-0.990) P<0.05

المجتمع المدروس: FinnGen insomnia GWAS population

review
[Nutrition in improving sleep quality and fighting insomnia].
Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral مقابل: Placebo التأثير: None None
Mendelian randomization
Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study.
Dose: None مقابل: Placebo التأثير: Folate vs chronotype OR 1.09 (95% CI 1.01-1.17); Vitamin B6 vs chronotype OR 0.91 (95% CI 0.86-0.96) Folate p=0.02; Vitamin B6 p=1.
prospective single-arm open-label pilot study n=40 4 weeks Open-label
A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: …
Dose: not specified per component مقابل: Placebo التأثير: mean sleep quality +1.9 points p < 0.001
Review
Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not?
Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: Crohn's disease patients (micronutrient deficiency)

Review
Strategies of Functional Foods Promote Sleep in Human Being.
Dose: None مقابل: None Outcome: Sleep quality and insomnia prevention التأثير: None None

المجتمع المدروس: Adults with insomnia or sleep disorders

Key Statistics

8

الدراسات

40

المشاركون

Positive

B

التقييم

Referenced Papers

Current signal transduction … 2014 41 اقتباسات
European journal of … 2012 225 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

sleep:
25-50 mg with B-complex
general:
1.3-1.7 mg/day

الحد الأعلى: 100 mg/day (neuropathy risk above)

الجرعات المدروسة في الأبحاث

الجرعة المدة التأثير ن
None -- Positive --
tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral -- Positive --
None -- Mixed --
not specified per component 4 weeks Positive 40
None -- Mixed --
None -- Positive --
None -- Positive --
5 mg -- Mixed --

أفضل وقت للتناول: Morning or with dinner; high doses before bed may increase dream vividness

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

  • Nausea
  • Peripheral neuropathy at high doses (>100 mg/day)
  • Vivid dreams
  • Heartburn

التفاعلات المعروفة

  • Levodopa — B6 may reduce effectiveness (without carbidopa)
  • Phenobarbital and phenytoin — B6 may reduce serum levels
  • Cycloserine — B6 deficiency may worsen side effects

الحد الأقصى المسموح به: 100 mg/day (neuropathy risk above)

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does فيتامين B6 help with الأرق?
Based on 8 studies with 40 participants, there is moderate evidence from clinical studies that فيتامين B6 may support الأرق management. Our evidence grade is B (Good Evidence).
How much فيتامين B6 should I take for الأرق?
Studies have used various dosages. A commonly studied range is 25-50 mg with B-complex. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of فيتامين B6?
Reported side effects may include Nausea, Peripheral neuropathy at high doses (>100 mg/day), Vivid dreams, Heartburn. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for فيتامين B6 and الأرق?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 40 total participants. The overall direction of effect is positive.

Related Evidence

إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.