Raiz de valeriana para Problemas de Sono Relacionados à Ansiedade
B Evidências Pelo menos um ensaio aleatorizado apoia esta conclusão, com resultados maioritariamente consistentes.Baseado em 11 estudos (4 meta-analyses). 9/11 estudos mostram efeitos positivos.
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B
Conclusão
Valerian root may help improve sleep when anxiety is a contributing factor, supported by mostly positive findings from multiple meta-analyses and reviews.
- 9 out of 11 studies (including 4 meta-analyses) show positive effects
- Research suggests valerian works through the GABA system to promote relaxation
- Long history of traditional use for nervousness and sleep problems
- Participant data not reported for this specific condition grouping
Key Study Findings
Review
The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, …
Dose: None
vs: Placebo
Efeito: None
None
Meta-Analysis
Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.
Dose: Various medicinal herbs: Silexan, Kava, Ginkgo biloba, Withania somnifera, Galphimia glauca, Passion
vs: Placebo
Efeito: Silexan MD -3.84 (95% CrI -6.31 to -1.34); Kava MD -2.46 (95% CrI -4.47 to -0.32); Ginkgo biloba MD
None
Review
Medicinal Plants for Insomnia Related to Anxiety: An Updated Review.
Dose: None
vs: Placebo
Efeito: None
None
in vitro / metabolic engineering study
Metabolic engineering of Escherichia coli for production of valerenadiene.
Dose: None
vs: Placebo
Efeito: highest yield: 62.0 mg/L valerenadiene (19.4 mg/L/OD600)
None
systematic review
[Use of valerian in anxiety and sleep disorders: what is the best evidence?].
Dose: variable valerian root extract doses
vs: Placebo
Efeito: None
None
In Vitro
Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats.
Dose: valerian root extract 3 ml/kg; valerenic acid 3 mg/kg; diazepam 1 mg/kg; ethanol 1 ml/kg
vs: Placebo
Efeito: significant reduction in anxious behavior vs ethanol control
Key Statistics
11
Estudos
--
Participantes
↑
Positive
B
Nota
Referenced Papers
Molecules (Basel, Switzerland)
2025
2 citações
Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.
Meta-Analysis
Pharmacological research
2022
51 citações
Nutrients
2021
85 citações
Planta medica
2021
41 citações
GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence.
Systematic Review
Phytotherapy research : …
2018
95 citações
Journal of biotechnology
2017
25 citações
Acta medica portuguesa
2011
21 citações
Phytomedicine : international …
2010
148 citações
Medical science monitor …
2009
85 citações
Journal of psychopharmacology …
2005
176 citações
Integrative cancer therapies
2004
59 citações
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosagens Comumente Utilizadas
- sleep:
- 300-600 mg standardized extract, 30 min before bed
Limite superior: Not established
Dosagens Estudadas em Pesquisas
| Dosagem | Duração | Efeito | N |
|---|---|---|---|
| None | -- | Positive | -- |
| Various medicinal herbs: Silexan, Kava, Ginkgo biloba, Withania somnifera, Galphimia glauca, Passion | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| variable valerian root extract doses | -- | Mixed | -- |
| valerian root extract 3 ml/kg; valerenic acid 3 mg/kg; diazepam 1 mg/kg; ethanol 1 ml/kg | -- | Positive | -- |
| None | -- | Positive | -- |
Melhor horário: 30-60 minutes before bed; may require 2-4 weeks for full effect
Safety & Side Effects
Efeitos Colaterais Relatados
- ⚠ Headache
- ⚠ Dizziness
- ⚠ GI upset
- ⚠ Morning grogginess
- ⚠ Vivid dreams
Interações Conhecidas
- ● Sedatives and alcohol — additive CNS depression
- ● CYP3A4-metabolized drugs — valerian may inhibit this enzyme
- ● Benzodiazepines — potential additive GABA effects
Ingestão máxima tolerável: Not established
Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
Frequently Asked Questions
Does Raiz de valeriana help with Problemas de Sono Relacionados à Ansiedade?
Based on 11 studies with 0 participants, there is moderate evidence from clinical studies that Raiz de valeriana may support Problemas de Sono Relacionados à Ansiedade management. Our evidence grade is B (Good Evidence).
How much Raiz de valeriana should I take for Problemas de Sono Relacionados à Ansiedade?
Studies have used various dosages. A commonly studied range is 300-600 mg standardized extract, 30 min before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Raiz de valeriana?
Reported side effects may include Headache, Dizziness, GI upset, Morning grogginess. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Raiz de valeriana and Problemas de Sono Relacionados à Ansiedade?
We rate the evidence as Grade B (Good Evidence). This rating is based on 11 peer-reviewed studies with 0 total participants. The overall direction of effect is positive.
Related Evidence
Outros ingredientes para Problemas de Sono Relacionados à Ansiedade
Raiz de valeriana para outras condições
References
- [1] Kacper Żełabowski et al.. Molecules. 2025. The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs. doi:10.3390/molecules30183814 PubMed
- [2] Wenting Zhang et al.. Pharmacol Res. 2022. Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis. doi:10.1016/j.phrs.2022.106204 PubMed
- [3] Oliviero Bruni et al.. Nutrients. 2021. Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep. doi:10.3390/nu13020530 PubMed
- [4] Silvia Borrás et al.. Planta Med. 2021. Medicinal Plants for Insomnia Related to Anxiety: An Updated Review. doi:10.1055/a-1510-9826 PubMed
- [5] Karen Savage et al.. Phytother Res. 2018. GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. doi:10.1002/ptr.5940 PubMed
- [6] S Eric Nybo et al.. J Biotechnol. 2017. Metabolic engineering of Escherichia coli for production of valerenadiene. doi:10.1016/j.jbiotec.2017.10.004 PubMed
- [7] Ana Nunes et al.. Acta Med Port. 2011. [Use of valerian in anxiety and sleep disorders: what is the best evidence?]. PubMed
- [8] K Murphy et al.. Phytomedicine. 2010. Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. doi:10.1016/j.phymed.2009.10.020 PubMed
- [9] Benjamin S Weeks. Med Sci Monit. 2009. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. PubMed
- [10] David Wheatley. J Psychopharmacol. 2005. Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. doi:10.1177/0269881105053309 PubMed
- [11] Keith I Block et al.. Integr Cancer Ther. 2004. Safety and efficacy of herbal sedatives in cancer care. doi:10.1177/1534735404265003 PubMed
Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.