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SleepCited

Skullcap for Anxiety-Related Sleep Problems

B

Based on 2 studies (1 meta-analysis). 2/2 studies show positive effects.

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            B

        

        

            
The Bottom Line

            
            
Based on 2 studies (1 meta-analysis). 2/2 studies show positive effects.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
2

        
Studies

    

    

        
--

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
Grade

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence.
                        
                        
                            
                                Systematic Review
                            
                            
                            
                        
                    

                    

                        Phytotherapy research : …
                        2018
                        
                        95 citations
                        
                    

                

                
                

                    

                        
                            Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Medical science monitor …
                        2009
                        
                        85 citations
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
sleep:

                        
350-500 mg dried herb or 1-2 mL tincture, before bed

                    

                    
                

                
                

                    Upper limit: Not formally established
                

                
            

            

            

            
            

                Best taken: 30-60 minutes before bed
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
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                            ⚠
                            Drowsiness (intended effect)
                        
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                            ⚠
                            Rare hepatotoxicity (usually from adulterated products)
                        
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                            ⚠
                            GI discomfort
                        
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Known Interactions

                    
    
                        
                        
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                            ●
                            Sedatives and benzodiazepines — additive CNS depression
                        
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                            Hepatotoxic medications — potential additive liver stress
                        
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                            Anticonvulsants — may alter seizure threshold
                        
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                        Tolerable upper intake: Not formally established
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Skullcap help with Anxiety-Related Sleep Problems?
            
        
        

            Based on 2 studies with 0 participants, there is moderate evidence from clinical studies that Skullcap may support Anxiety-Related Sleep Problems management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Skullcap should I take for Anxiety-Related Sleep Problems?
            
        
        

            Studies have used various dosages. A commonly studied range is 350-500 mg dried herb or 1-2 mL tincture, before bed. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Skullcap?
            
        
        

            Reported side effects may include Drowsiness (intended effect), Rare hepatotoxicity (usually from adulterated products), GI discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Skullcap and Anxiety-Related Sleep Problems?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 2 peer-reviewed studies with 0 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
                

                    
Skullcap for other conditions

                    

                        
                        
                            Hyperarousal and Cognitive Insomnia
                            B

                        
                        
                    

                

                
            

        

        

    


    
    












    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.