Valerian Root
herbAlso known as: Valeriana officinalis, All-heal, Garden heliotrope
About
Valerian root is one of the most widely studied herbal sleep aids, used for centuries in traditional medicine. Research suggests it may support sleep quality by increasing GABA availability in the brain, though effects may take 2-4 weeks of consistent use to become apparent.
How It Works
Valerenic acid inhibits GABA breakdown (GABA transaminase inhibitor); isovaleric acid is a partial GABA-A agonist.
Evidence For Conditions
| Condition | Grade | Studies | Participants | |
|---|---|---|---|---|
| Insomnia | A Strong | 40 | 9762 | Xem → |
| Anxiety-Related Sleep Problems | B Moderate | 11 | -- | Xem → |
| Sleep Onset Difficulty | B Moderate | 5 | 15 | Xem → |
Side Effects
- Headache
- Dizziness
- GI upset
- Morning grogginess
- Vivid dreams
Drug & Supplement Interactions
- Sedatives and alcohol — additive CNS depression
- CYP3A4-metabolized drugs — valerian may inhibit this enzyme
- Benzodiazepines — potential additive GABA effects
Always inform your healthcare provider about all supplements you take.
Related Ingredients
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.