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Magnesium Glycinate for Anxiety-Related Sleep Problems

B

Based on 1 study (1 meta-analysis) with 2,619 total participants. 1/1 studies show positive effects.

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The Bottom Line

            
            
Magnesium may help with sleep problems caused by anxiety based on one positive systematic review, but more research is needed for this specific use.

            
            
            
    
                
                
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                    Only 1 systematic review with 2,619 participants available for this specific use
                
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                    Magnesium supports GABA activity, which is important for calming the nervous system
                
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                    Grade B evidence based on the quality of the single study (systematic review)
                
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                    Broader magnesium research for insomnia and sleep onset is much stronger
                
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Key Statistics





            


    

        
1

        
Studies

    

    

        
2619

        
Participants

    

    

        
            
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Positive

    

    

        B

        
Grade

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review.
                        
                        
                            
                                Systematic Review
                            
                            
                            
                        
                    

                    

                        Nutrition journal
                        2010
                        
                        187 citations
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
200-400 mg elemental Mg, before bed

                    

                    
                

                
                

                    Upper limit: 350 mg/day (supplemental Mg)
                

                
            

            

            

            
            

                Best taken: 30-60 minutes before bed
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
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                            Loose stools or diarrhea
                        
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                            Nausea
                        
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                            Abdominal cramping
                        
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                            Low blood pressure at high doses
                        
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Known Interactions

                    
    
                        
                        
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                            Antibiotics (tetracyclines, fluoroquinolones) — may reduce absorption
                        
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                            Bisphosphonates — magnesium may decrease efficacy
                        
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                            Blood pressure medications — additive hypotensive effects
                        
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                        Tolerable upper intake: 350 mg/day (supplemental Mg)
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Magnesium Glycinate help with Anxiety-Related Sleep Problems?
            
        
        

            Based on 1 studies with 2,619 participants, there is moderate evidence from clinical studies that Magnesium Glycinate may support Anxiety-Related Sleep Problems management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Magnesium Glycinate should I take for Anxiety-Related Sleep Problems?
            
        
        

            Studies have used various dosages. A commonly studied range is 200-400 mg elemental Mg, before bed. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Magnesium Glycinate?
            
        
        

            Reported side effects may include Loose stools or diarrhea, Nausea, Abdominal cramping, Low blood pressure at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Magnesium Glycinate and Anxiety-Related Sleep Problems?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 1 peer-reviewed studies with 2,619 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
                
                
            

        

        

    


    
    












    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.