KavaKava
herb
Kava
Kava
别名: Piper methysticum, Kava kava, Awa
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About
卡瓦根（学名 Piper methysticum）含有卡瓦内酯，可通过调节GABA-A受体及电压门控钠通道发挥抗焦虑与肌肉舒缓作用。临床试验支持其用于缓解焦虑，从而可间接支持入睡过程。请注意，卡瓦根存在潜在的肝毒性风险，使用前建议咨询专业医疗人员，以确保安全合理地使用。
How It Works
Kavalactones (kavain, methysticin) enhance GABA-A receptor binding; block voltage-gated sodium and calcium channels; reduce norepinephrine reuptake for anxiolysis.
Evidence For Conditions
Side Effects
- Drowsiness and reduced coordination
- Hepatotoxicity (rare but serious — consult healthcare provider)
- Skin rash (kava dermopathy) with chronic high-dose use
- GI discomfort
Drug & Supplement Interactions
- Alcohol — increased hepatotoxicity risk and CNS depression
- Hepatotoxic medications (acetaminophen, statins) — additive liver stress
- Benzodiazepines and sedatives — additive CNS depression
- CYP450 substrates (2E1, 1A2, 2D6) — kavalactones may inhibit metabolism
- Levodopa and dopaminergic drugs — kava may reduce efficacy
请务必告知您的医疗保健提供者您正在服用的所有补充剂。
Related Ingredients
FDA 免责声明: 这些声明未经美国食品药品监督管理局（FDA）评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析，不构成医疗建议。在开始任何补充剂方案之前，请务必咨询您的医疗保健提供者。