KavaKava
herb
别名: Piper methysticum, Kava kava, Awa
About
Kava (Piper methysticum) contains kavalactones that demonstrate anxiolytic and muscle-relaxant properties through modulation of GABA-A receptors and voltage-gated sodium channels. Clinical trials support its use for anxiety reduction, which may indirectly improve sleep onset. Consult your healthcare provider regarding hepatotoxicity concerns.
How It Works
Kavalactones (kavain, methysticin) enhance GABA-A receptor binding; block voltage-gated sodium and calcium channels; reduce norepinephrine reuptake for anxiolysis.
Evidence For Conditions
Side Effects
- Drowsiness and reduced coordination
- Hepatotoxicity (rare but serious — consult healthcare provider)
- Skin rash (kava dermopathy) with chronic high-dose use
- GI discomfort
Drug & Supplement Interactions
- Alcohol — increased hepatotoxicity risk and CNS depression
- Hepatotoxic medications (acetaminophen, statins) — additive liver stress
- Benzodiazepines and sedatives — additive CNS depression
- CYP450 substrates (2E1, 1A2, 2D6) — kavalactones may inhibit metabolism
- Levodopa and dopaminergic drugs — kava may reduce efficacy
请务必告知您的医疗保健提供者您正在服用的所有补充剂。
Related Ingredients
FDA 免责声明: 这些声明未经美国食品药品监督管理局(FDA)评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析,不构成医疗建议。在开始任何补充剂方案之前,请务必咨询您的医疗保健提供者。