B6 Vitamini için Uykusuzluk

5 çalışmaya (1 RCT), toplam 50 katılımcıyla dayanmaktadır. 3/5 çalışma olumlu etkiler göstermektedir.

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Sonuç

Vitamin B6 may play a role in supporting sleep through its involvement in melatonin production, but the direct evidence for insomnia is limited and preliminary.

Only 5 studies with 50 total participants — evidence is preliminary
B6 is involved in producing serotonin and melatonin, both important for sleep
Genetic studies (Mendelian randomization) suggest a link between B6 and sleep behaviors
More clinical trials with larger sample sizes are needed

Key Study Findings

Other

Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study.

Dose: None vs: None Outcome: Causal association of nutrients with insomnia Etki: Magnesium OR 0.869 (95% CI 0.763-0.990) P<0.05

Popülasyon: FinnGen insomnia GWAS population

review

[Nutrition in improving sleep quality and fighting insomnia].

Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral vs: Placebo Etki: None None

Mendelian randomization

Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study.

Dose: None vs: Placebo Etki: Folate vs chronotype OR 1.09 (95% CI 1.01-1.17); Vitamin B6 vs chronotype OR 0.91 (95% CI 0.86-0.96) Folate p=0.02; Vitamin B6 p=1.

prospective single-arm open-label pilot study n=40 4 weeks Open-label

A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: …

Dose: not specified per component vs: Placebo Etki: mean sleep quality +1.9 points p < 0.001

Review

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not?

Dose: None vs: None Outcome: None Etki: None None

Popülasyon: Crohn's disease patients (micronutrient deficiency)

Review

Strategies of Functional Foods Promote Sleep in Human Being.

Dose: None vs: None Outcome: Sleep quality and insomnia prevention Etki: None None

Popülasyon: Adults with insomnia or sleep disorders

Key Statistics

Çalışmalar

Katılımcılar

↑

Positive

Derece

Referenced Papers

Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study. Other

Medicine 2025

[Nutrition in improving sleep quality and fighting insomnia]. Review

Nutricion hospitalaria 2025

Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study. Other

Brain and behavior 2025

A Cross-Sectional Study on the Drug Use of Insomnia in a Chinese Medicine Hospital in Shenzhen. Other

Psychiatry and clinical … 2025

A genome-wide methylation analysis of Chinese Han patients with chronic insomnia disorder. Other

Sleep & breathing … 2024

A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. Other

Complementary therapies in … 2019 26 atıf

Exploring the Effect of Lactium™ and Zizyphus Complex on Sleep Quality: A Double-Blind, Randomized Placebo-Controlled Trial. RCT

Nutrients 2017 27 atıf

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? Review

Digestive diseases (Basel, … 2016 41 atıf

Strategies of Functional Foods Promote Sleep in Human Being. Other

Current signal transduction … 2014 41 atıf

Complementary and alternative medicine (CAM) use in an Italian cohort of pediatric headache patients: the tip of the iceberg. Other

Neurological sciences : … 2014

Nutritional and safety outcomes from an open-label micronutrient intervention for pediatric bipolar spectrum disorders. Other

Journal of child … 2013

Influence of mineral and vitamin supplements on pregnancy outcome. Review

European journal of … 2012 225 atıf

Kidney damage in acute intermittent porphyria. Other

Przeglad lekarski 2011

Sleep disturbances, oxidative stress and cardiovascular risk parameters in postmenopausal women complaining of insomnia. Other

Climacteric : the … 2006

Vitamin supplements and cardiovascular risk: review of the randomized trials of homocysteine-lowering vitamin supplements. Review

Seminars in thrombosis … 2000 194 atıf

Nutritional factors in the etiology of the premenstrual tension syndromes. Other

The Journal of … 1983

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Yaygın Kullanılan Dozajlar

sleep:: 25-50 mg with B-complex
general:: 1.3-1.7 mg/day

Üst sınır: 100 mg/day (neuropathy risk above)

Araştırmalarda İncelenen Dozajlar

Dozaj	Süre	Etki	N
None	--	Positive	--
tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral	--	Positive	--
None	--	Mixed	--
not specified per component	4 weeks	Positive	40
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--
5 mg	--	Mixed	--

En iyi alım zamanı: Morning or with dinner; high doses before bed may increase dream vividness

Safety & Side Effects

Bildirilen Yan Etkiler

⚠ Nausea
⚠ Peripheral neuropathy at high doses (>100 mg/day)
⚠ Vivid dreams
⚠ Heartburn

Bilinen Etkileşimler

● Levodopa — B6 may reduce effectiveness (without carbidopa)
● Phenobarbital and phenytoin — B6 may reduce serum levels
● Cycloserine — B6 deficiency may worsen side effects

Tolere edilebilir üst alım: 100 mg/day (neuropathy risk above)

Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.

Frequently Asked Questions

Does B6 Vitamini help with Uykusuzluk?

Based on 8 studies with 40 participants, there is moderate evidence from clinical studies that B6 Vitamini may support Uykusuzluk management. Our evidence grade is B (Good Evidence).

How much B6 Vitamini should I take for Uykusuzluk?

Studies have used various dosages. A commonly studied range is 25-50 mg with B-complex. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of B6 Vitamini?

Reported side effects may include Nausea, Peripheral neuropathy at high doses (>100 mg/day), Vivid dreams, Heartburn. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for B6 Vitamini and Uykusuzluk?

We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 40 total participants. The overall direction of effect is positive.

Related Evidence

Şu durum için diğer içerikler: Uykusuzluk

Melatonin A Valerian Kökü A CBD A Omega-3 Yağ Asitleri A Tryptophan A D Vitamini A

B6 Vitamini diğer sağlık durumları için

Uykuya Dalma Güçlüğü A

Hızlı Değerlendirme

5 çalışmaya (1 RCT), toplam 50 katılımcıyla dayanmaktadır. 3/5 çalışma olumlu etkiler göstermektedir.

Evidence Strength72%

High confidence

Çalışma Dağılımı

RCT (1)Meta (0)Other (7)

Alternatifleri Karşılaştır

Bu durum için diğer bileşenlerin nasıl karşılaştırıldığını görün.Diğer içeriklerin bu sağlık durumu için nasıl karşılaştırıldığını görün.

Şu durum için tüm içerikleri görüntüle: Uykusuzluk

Daha Fazla Bilgi

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