CBD para Problemas de Sono Relacionados à Ansiedade

Baseado em 35 estudos (5 meta-analyses, 11 RCTs) com 17,358 participantes no total. 19/35 estudos mostram efeitos positivos.

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Conclusão

CBD may support better sleep in people whose rest is disrupted by anxiety, though results are mixed and the best dose and formulation are still being studied.

35 studies with 17,358 participants — the largest evidence base among anxiety-sleep supplements
Roughly 54% of studies show positive effects, with others showing mixed results
May work through 5-HT1A serotonin receptors to reduce anxiety and promote sleep
Dosing varies widely across studies (25 mg to 300+ mg), making direct comparisons difficult

Key Study Findings

Other

Development of a novel Δ9-THC-specific color test reagent.

Dose: None vs: None Outcome: None Efeito: None None

População: Lab study: novel THC-specific color test reagent

Observational Study

Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions …

Dose: None vs: None Outcome: DALYs and mortality rates of congenital birth defects Efeito: DALYs decreased 59.77%, deaths decreased 63.81% None

População: G20 countries population, 1990-2021

Other

Policy reform and the international future of Moroccan Cannabis production.

Dose: None vs: None Outcome: None Efeito: None None

População: None

Observational Study n=126

The use of complementary and alternative medicine among cancer patients in Hawaii.

Dose: None vs: None Outcome: CAM therapy use patterns among cancer patients Efeito: 57.1% used at least one CAM therapy None

População: Cancer patients in Hawaii

Systematic Review

The Effect of Cannabidiol on Performance and Post-Load Recovery among Healthy and Physically Active Individuals: …

Dose: None vs: None Outcome: None Efeito: None None

População: Healthy adults

Other 5 weeks

Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS-Induced Colitis …

Dose: 200 mg vs: None Outcome: Colitis severity Efeito: None None

População: Mouse model

Key Statistics

Estudos

1794

Participantes

↔

Mixed

Nota

Referenced Papers

Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions for 2022-2040. Other

BMC pregnancy and … 2025 6 citações

Development of a novel Δ9-THC-specific color test reagent. Other

Forensic toxicology 2025 1 citações

Policy reform and the international future of Moroccan Cannabis production. Other

The International journal … 2025 1 citações

The use of complementary and alternative medicine among cancer patients in Hawaii. Other

BMC complementary medicine … 2025

Pharmacokinetic Variability of Oral Cannabidiol and Its Major Metabolites after Short-Term High-Dose Exposure in Healthy Subjects. Other

Medical cannabis and … 2024 26 citações

Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS-Induced Colitis Mice. Other

Molecular nutrition & … 2024 15 citações

Cannabidiol Exerts Sedative and Hypnotic Effects in Normal and Insomnia Model Mice Through Activation of 5-HT1A Receptor. Other

Neurochemical research 2024 14 citações

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes. Other

Cannabis and cannabinoid … 2024 10 citações

A systematic review and meta-analysis of functional vitamin B12 status among adult vegans. Meta-Analysis

Nutrition bulletin 2024 9 citações

Interaction Between Peroxisome Proliferator-Activated Receptors and Cannabidiol in the Gut of Chickens Applied to Different Challenge Conditions. Other

International journal of … 2024 7 citações

Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review. Systematic Review

Nutrients 2024 5 citações

The Effect of Cannabidiol on Performance and Post-Load Recovery among Healthy and Physically Active Individuals: A Systematic Review. Systematic Review

Nutrients 2024 4 citações

Evaluation of the Drug-Drug Interaction Potential of Cannabidiol Against UGT2B7-Mediated Morphine Metabolism Using Physiologically Based Pharmacokinetic Modeling. Other

Pharmaceutics 2024 4 citações

Medicinal cannabis improves sleep in adults with insomnia: a randomised double-blind placebo-controlled crossover study. RCT

Journal of sleep … 2023 40 citações

A micronutrient mixture with collagen peptides, probiotics, cannabidiol, and diet may reduce aging, and development and progression of age-related alzheimer's … Other

Mechanisms of ageing … 2023 8 citações

A Systematic Review of the Benefit of B-Vitamins as a Complementary Treatment in Cancer Patients. Systematic Review

Nutrition and cancer 2023 5 citações

Vitamin B6: a scoping review for Nordic Nutrition Recommendations 2023. Review

Food & nutrition … 2023 5 citações

Apical Vertebras Distribution Modifier for Coronal Balance Classification in Adult Idiopathic Scoliosis. Other

Journal of personalized … 2023 3 citações

Top 20 Research Studies of 2022 for Primary Care Physicians. Other

American family physician 2023

Topical Cannabidiol (CBD) After Total Knee Arthroplasty Does Not Decrease Pain or Opioid Use: A Prospective Randomized Double-Blinded Placebo-Controlled Trial. RCT

The Journal of … 2022 35 citações

Therapeutic Claims in Cannabidiol (CBD) Marketing Messages on Twitter. Other

Proceedings. IEEE International … 2021 29 citações

Prevalence of Cannabidiol Use in Patients With Spine Complaints: Results of an Anonymous Survey. Other

International journal of … 2021 14 citações

Cannabinoid, Terpene, and Heavy Metal Analysis of 29 Over-the-Counter Commercial Veterinary Hemp Supplements. Other

Veterinary medicine (Auckland, … 2020 45 citações

A Case of Toxicity from Cannabidiol Gummy Ingestion. Case Report

Cureus 2020 23 citações

Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies. Case Report

Brain sciences 2020 12 citações

Community-based distribution of iron-folic acid supplementation in low- and middle-income countries: a review of evidence and programme implications. Review

Public health nutrition 2018 35 citações

NUTRITIONAL AND TOXICOLOGICAL ASPECTS OF SPIRULINA (ARTHROSPIRA). Review

Nutricion hospitalaria 2015 161 citações

Vitamin B12, folic acid, and bone. Review

Current osteoporosis reports 2013 43 citações

Considering biomedical/CAM treatments. Review

Adolescent medicine: state … 2013 3 citações

Vitamin B12 and cognitive function: an evidence-based analysis. Review

Ontario health technology … 2013

Systematic review: Progression of beryllium sensitization to chronic beryllium disease. Systematic Review

Occupational medicine (Oxford, … 2012 33 citações

Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. Systematic Review

Archives of internal … 2007 222 citações

A systematic review of the evidence supporting the use of priority dispatch of emergency ambulances. Systematic Review

Prehospital emergency care 2002 33 citações

Chemoprevention of bladder cancer. Review

The Urologic clinics … 2002 20 citações

Vitamin B6 requirements and recommendations. Review

European journal of … 1989

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

sleep:: 25-150 mg, 1 hour before bed

Limite superior: Not established; FDA max studied ~20 mg/kg/day

Dosagens Estudadas em Pesquisas

Dosagem	Duração	Efeito	N
None	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	126
None	--	Positive	--
200 mg	5 weeks	Positive	--
cannabidiol (CBD) at various doses administered to mice	--	Positive	--
None	--	Positive	--

Melhor horário: 1 hour before bed

Safety & Side Effects

Efeitos Colaterais Relatados

⚠ Fatigue
⚠ Diarrhea
⚠ Changes in appetite
⚠ Dry mouth
⚠ Liver enzyme elevation at high doses

Interações Conhecidas

● CYP3A4/CYP2C19 substrates — CBD inhibits these liver enzymes
● Blood thinners (warfarin) — CBD may increase warfarin levels
● Clobazam — CBD significantly increases clobazam levels
● Sedatives — additive drowsiness

Ingestão máxima tolerável: Not established; FDA max studied ~20 mg/kg/day

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does CBD help with Problemas de Sono Relacionados à Ansiedade?

Based on 35 studies with 1,794 participants, there is strong evidence from multiple clinical trials that CBD may support Problemas de Sono Relacionados à Ansiedade management. Our evidence grade is A (Strong Evidence).

How much CBD should I take for Problemas de Sono Relacionados à Ansiedade?

Studies have used various dosages. A commonly studied range is 25-150 mg, 1 hour before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of CBD?

Reported side effects may include Fatigue, Diarrhea, Changes in appetite, Dry mouth. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for CBD and Problemas de Sono Relacionados à Ansiedade?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 35 peer-reviewed studies with 1,794 total participants. The overall direction of effect is mixed.

Related Evidence

Outros ingredientes para Problemas de Sono Relacionados à Ansiedade

Kava A Lavanda A Passiflora A Raiz de valeriana B Manjericão sagrado B GABA B

CBD para outras condições

Insônia A

Veredito Rápido

Baseado em 35 estudos (5 meta-analyses, 11 RCTs) com 17,358 participantes no total. 19/35 estudos mostram efeitos positivos.

Evidence Strength92%

High confidence

Detalhamento dos Estudos

RCT (2)Meta (1)Other (32)

Comparar Alternativas

Veja como outros ingredientes se comparam para esta condição.

Ver todos os ingredientes para Problemas de Sono Relacionados à Ansiedade

Saiba Mais

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.