CBD（大麻二酚）用于焦虑相关性睡眠问题

基于35项研究（5项荟萃分析、11项RCT），共17,358名参与者。19/35项研究显示积极效果。

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结论

CBD may support better sleep in people whose rest is disrupted by anxiety, though results are mixed and the best dose and formulation are still being studied.

35 studies with 17,358 participants — the largest evidence base among anxiety-sleep supplements
Roughly 54% of studies show positive effects, with others showing mixed results
May work through 5-HT1A serotonin receptors to reduce anxiety and promote sleep
Dosing varies widely across studies (25 mg to 300+ mg), making direct comparisons difficult

Key Study Findings

Other

Development of a novel Δ9-THC-specific color test reagent.

Dose: None vs: None Outcome: None 效果: None None

研究人群: Lab study: novel THC-specific color test reagent

Observational Study

Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions …

Dose: None vs: None Outcome: DALYs and mortality rates of congenital birth defects 效果: DALYs decreased 59.77%, deaths decreased 63.81% None

研究人群: G20 countries population, 1990-2021

Other

Policy reform and the international future of Moroccan Cannabis production.

Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Observational Study n=126

The use of complementary and alternative medicine among cancer patients in Hawaii.

Dose: None vs: None Outcome: CAM therapy use patterns among cancer patients 效果: 57.1% used at least one CAM therapy None

研究人群: Cancer patients in Hawaii

Systematic Review

The Effect of Cannabidiol on Performance and Post-Load Recovery among Healthy and Physically Active Individuals: …

Dose: None vs: None Outcome: None 效果: None None

研究人群: Healthy adults

Other 5 weeks

Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS-Induced Colitis …

Dose: 200 mg vs: None Outcome: Colitis severity 效果: None None

研究人群: Mouse model

Key Statistics

研究数量

1794

受试者

↔

Mixed

等级

Referenced Papers

Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions for 2022-2040. Other

BMC pregnancy and … 2025 6 次引用

Development of a novel Δ9-THC-specific color test reagent. Other

Forensic toxicology 2025 1 次引用

Policy reform and the international future of Moroccan Cannabis production. Other

The International journal … 2025 1 次引用

The use of complementary and alternative medicine among cancer patients in Hawaii. Other

BMC complementary medicine … 2025

Pharmacokinetic Variability of Oral Cannabidiol and Its Major Metabolites after Short-Term High-Dose Exposure in Healthy Subjects. Other

Medical cannabis and … 2024 26 次引用

Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS-Induced Colitis Mice. Other

Molecular nutrition & … 2024 15 次引用

Cannabidiol Exerts Sedative and Hypnotic Effects in Normal and Insomnia Model Mice Through Activation of 5-HT1A Receptor. Other

Neurochemical research 2024 14 次引用

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes. Other

Cannabis and cannabinoid … 2024 10 次引用

A systematic review and meta-analysis of functional vitamin B12 status among adult vegans. Meta-Analysis

Nutrition bulletin 2024 9 次引用

Interaction Between Peroxisome Proliferator-Activated Receptors and Cannabidiol in the Gut of Chickens Applied to Different Challenge Conditions. Other

International journal of … 2024 7 次引用

Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review. Systematic Review

Nutrients 2024 5 次引用

The Effect of Cannabidiol on Performance and Post-Load Recovery among Healthy and Physically Active Individuals: A Systematic Review. Systematic Review

Nutrients 2024 4 次引用

Evaluation of the Drug-Drug Interaction Potential of Cannabidiol Against UGT2B7-Mediated Morphine Metabolism Using Physiologically Based Pharmacokinetic Modeling. Other

Pharmaceutics 2024 4 次引用

Medicinal cannabis improves sleep in adults with insomnia: a randomised double-blind placebo-controlled crossover study. RCT

Journal of sleep … 2023 40 次引用

A micronutrient mixture with collagen peptides, probiotics, cannabidiol, and diet may reduce aging, and development and progression of age-related alzheimer's … Other

Mechanisms of ageing … 2023 8 次引用

A Systematic Review of the Benefit of B-Vitamins as a Complementary Treatment in Cancer Patients. Systematic Review

Nutrition and cancer 2023 5 次引用

Vitamin B6: a scoping review for Nordic Nutrition Recommendations 2023. Review

Food & nutrition … 2023 5 次引用

Apical Vertebras Distribution Modifier for Coronal Balance Classification in Adult Idiopathic Scoliosis. Other

Journal of personalized … 2023 3 次引用

Top 20 Research Studies of 2022 for Primary Care Physicians. Other

American family physician 2023

Topical Cannabidiol (CBD) After Total Knee Arthroplasty Does Not Decrease Pain or Opioid Use: A Prospective Randomized Double-Blinded Placebo-Controlled Trial. RCT

The Journal of … 2022 35 次引用

Therapeutic Claims in Cannabidiol (CBD) Marketing Messages on Twitter. Other

Proceedings. IEEE International … 2021 29 次引用

Prevalence of Cannabidiol Use in Patients With Spine Complaints: Results of an Anonymous Survey. Other

International journal of … 2021 14 次引用

Cannabinoid, Terpene, and Heavy Metal Analysis of 29 Over-the-Counter Commercial Veterinary Hemp Supplements. Other

Veterinary medicine (Auckland, … 2020 45 次引用

A Case of Toxicity from Cannabidiol Gummy Ingestion. Case Report

Cureus 2020 23 次引用

Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies. Case Report

Brain sciences 2020 12 次引用

Community-based distribution of iron-folic acid supplementation in low- and middle-income countries: a review of evidence and programme implications. Review

Public health nutrition 2018 35 次引用

NUTRITIONAL AND TOXICOLOGICAL ASPECTS OF SPIRULINA (ARTHROSPIRA). Review

Nutricion hospitalaria 2015 161 次引用

Vitamin B12, folic acid, and bone. Review

Current osteoporosis reports 2013 43 次引用

Considering biomedical/CAM treatments. Review

Adolescent medicine: state … 2013 3 次引用

Vitamin B12 and cognitive function: an evidence-based analysis. Review

Ontario health technology … 2013

Systematic review: Progression of beryllium sensitization to chronic beryllium disease. Systematic Review

Occupational medicine (Oxford, … 2012 33 次引用

Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. Systematic Review

Archives of internal … 2007 222 次引用

A systematic review of the evidence supporting the use of priority dispatch of emergency ambulances. Systematic Review

Prehospital emergency care 2002 33 次引用

Chemoprevention of bladder cancer. Review

The Urologic clinics … 2002 20 次引用

Vitamin B6 requirements and recommendations. Review

European journal of … 1989

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

sleep:: 25-150 mg, 1 hour before bed

上限： Not established; FDA max studied ~20 mg/kg/day

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	126
None	--	Positive	--
200 mg	5 weeks	Positive	--
cannabidiol (CBD) at various doses administered to mice	--	Positive	--
None	--	Positive	--

最佳服用时间： 1 hour before bed

Safety & Side Effects

已报告的副作用

⚠ Fatigue
⚠ Diarrhea
⚠ Changes in appetite
⚠ Dry mouth
⚠ Liver enzyme elevation at high doses

已知相互作用

● CYP3A4/CYP2C19 substrates — CBD inhibits these liver enzymes
● Blood thinners (warfarin) — CBD may increase warfarin levels
● Clobazam — CBD significantly increases clobazam levels
● Sedatives — additive drowsiness

可耐受最高摄入量： Not established; FDA max studied ~20 mg/kg/day

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does CBD（大麻二酚） help with 焦虑相关性睡眠问题?

Based on 35 studies with 1,794 participants, there is strong evidence from multiple clinical trials that CBD（大麻二酚） may support 焦虑相关性睡眠问题 management. Our evidence grade is A (Strong Evidence).

How much CBD（大麻二酚） should I take for 焦虑相关性睡眠问题?

Studies have used various dosages. A commonly studied range is 25-150 mg, 1 hour before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of CBD（大麻二酚）?

Reported side effects may include Fatigue, Diarrhea, Changes in appetite, Dry mouth. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for CBD（大麻二酚） and 焦虑相关性睡眠问题?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 35 peer-reviewed studies with 1,794 total participants. The overall direction of effect is mixed.

Related Evidence

其他成分用于焦虑相关性睡眠问题

Kava A 薰衣草 A 西番莲 A 缬草根 B 圣罗勒（Holy Basil） B GABA（γ-氨基丁酸） B

CBD（大麻二酚）用于其他健康状况

失眠 A

快速结论

基于35项研究（5项荟萃分析、11项RCT），共17,358名参与者。19/35项研究显示积极效果。

Evidence Strength92%

High confidence

研究分析

RCT (2)Meta (1)Other (32)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于焦虑相关性睡眠问题

了解更多

FDA 免责声明: 这些声明未经美国食品药品监督管理局（FDA）评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析，不构成医疗建议。在开始任何补充剂方案之前，请务必咨询您的医疗保健提供者。

CBD（大麻二酚） 用于 焦虑相关性睡眠问题

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结论

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

常用剂量

研究中使用的剂量

Safety & Side Effects

已报告的副作用

已知相互作用

Frequently Asked Questions

Related Evidence

其他成分用于 焦虑相关性睡眠问题

CBD（大麻二酚） 用于其他健康状况

CBD（大麻二酚）用于焦虑相关性睡眠问题

其他成分用于焦虑相关性睡眠问题

CBD（大麻二酚）用于其他健康状况