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Effects of serotonin synthesis inhibition on sleep in hippocampectomized rats.

R F Laguzzi
Other Brain research 1982 2 trích dẫn
PubMed DOI
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Study Design

Loại nghiên cứu
Animal study
Can thiệp
Effects of serotonin synthesis inhibition on sleep in hippocampectomized rats. None
Đối chứng
Placebo
Xu hướng hiệu quả
Positive
Nguy cơ sai lệch
Moderate

Abstract

In adult rats an anterodorsal bilateral hippocampectomy produced an increase in motor activity without modification of the amount of the different sleep stages. In hippocampectomized rats p-chlorophenylalanine produced an insomnia which can be reversed by 5-HTP. These results show that the insomnia produced by brain serotonin depletion is not a result of the hyperactivity produced by the treatments which cause such depletion.

Used In Evidence Reviews

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