Effects of serotonin synthesis inhibition on sleep in hippocampectomized rats.

R F Laguzzi

Other Brain research 1982 2 citations

<\/script>\n

`; }, get iframeSnippet() { const domain = 'sleepcited.com'; const params = 'pmid\u003D6212096'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

Study Design

Study Type: Animal study

Intervention: Effects of serotonin synthesis inhibition on sleep in hippocampectomized rats. None
Comparator: Placebo
Effect Direction: Positive
Risk of Bias: Moderate

Abstract

In adult rats an anterodorsal bilateral hippocampectomy produced an increase in motor activity without modification of the amount of the different sleep stages. In hippocampectomized rats p-chlorophenylalanine produced an insomnia which can be reversed by 5-HTP. These results show that the insomnia produced by brain serotonin depletion is not a result of the hyperactivity produced by the treatments which cause such depletion.

Used In Evidence Reviews

B 5-HTP for Insomnia

Effects of serotonin synthesis inhibition on sleep in hippocampectomized rats.

Embed This Widget

Study Design

Abstract

Used In Evidence Reviews

Similar Papers

5-Hydroxytryptophan: a clinically-effective serotonin precursor.

Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian.

Spinosin, a C-glycoside flavonoid from semen Zizhiphi Spinozae, potentiated pentobarbital-induced sleep via the serotonergic system.

Engineering bacterial phenylalanine 4-hydroxylase for microbial synthesis of human neurotransmitter precursor 5-hydroxytryptophan.

Complementary and alternative medicine (CAM) use in an Italian cohort of pediatric headache patients: the tip of the iceberg.

Antidepressant activity of standardised extract of Marsilea minuta Linn.