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Effects of serotonin synthesis inhibition on sleep in hippocampectomized rats.

R F Laguzzi
Other Brain research 1982 2 atıf
PubMed DOI
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Study Design





            

                

                    

                        
                        

                            
Çalışma Türü

                            
Animal study

                        

                        
                        
                        
                        
                    

                    

                        
                        

                            
Müdahale

                            
Effects of serotonin synthesis inhibition on sleep in hippocampectomized rats. None

                        

                        
                        
                        

                            
Karşılaştırıcı

                            
Placebo

                        

                        
                        
                        

                            
Etki Yönü

                            

                                
                                    Positive
                                
                            

                        

                        
                        

                            
Yanlılık Riski

                            
Moderate

                        

                        
                    

                

            

        

        

        
        
        

            

  
Abstract





            

                
In adult rats an anterodorsal bilateral hippocampectomy produced an increase in motor activity without modification of the amount of the different sleep stages. In hippocampectomized rats p-chlorophenylalanine produced an insomnia which can be reversed by 5-HTP. These results show that the insomnia produced by brain serotonin depletion is not a result of the hyperactivity produced by the treatments which cause such depletion.

            

        

        

        
        

        
        

        
        

        
        

        
        

        
        
        

            

  
Used In Evidence Reviews





            

                
                
                    

                        B

                        
                            5-HTP için Uykusuzluk
                        
                    

                    
                
                
            

        

        

        
        
        

            

  
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