5-HTP için Uykusuzluk
B42 çalışmaya (1 RCT), toplam 84 katılımcıyla dayanmaktadır. 35/42 çalışma olumlu etkiler göstermektedir.
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B
Sonuç
5-HTP may support better sleep through its role in serotonin and melatonin production, but human evidence remains limited despite strong preclinical results.
- 35 out of 42 studies show positive effects on sleep, but most are animal or lab studies
- 5-HTP is a natural precursor to serotonin and melatonin, key neurotransmitters for sleep regulation
- Only 1 randomized controlled trial (RCT) in humans has been conducted
- A GABA/5-HTP combination has shown sleep-promoting effects in preclinical models
Key Study Findings
animal study / preclinical
Guhan Yangsheng Jing alleviates sleep deprivation-induced neuronal injury via neurotransmitter rebalancing, mitochondrial protection, and inhibition …
Dose: Guhan Yangsheng Jing (GHYSJ) multi-herbal decoction (dose not specified in abstract)
vs: Placebo
Etki: None
None
Other
Sleep deprivation activated AMPK/FOXO3a signaling mediates pineal autophagy impairment to reduce melatonin secretion in CUMS …
Dose: None
vs: CUMS+SD model without intervention
Outcome: Depression/insomnia behaviors and melatonin secretion
Etki: None
None
Popülasyon: CUMS + sleep deprivation rat model
preclinical animal/in vitro study
Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …
Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL
vs: Placebo
Etki: None
None
Animal Study
Promotion of sleep by cinnamic acid in parachlorophenylalanine-induced insomnia in rats.
Dose: Cinnamic acid (CA) administered to rats (dose not specified)
vs: Placebo
Etki: None
None
Animal study
Ginsenoside Rg1 alleviates PCPA-induced insomnia by inhibiting NLRP3 inflammasome activation and pyroptosis through the Nrf2/HO-1 …
Dose: None
vs: Placebo
Etki: None
None
animal study / preclinical
[Effect of Fushen Decoction on 5-HT system and GABA expression in mouse model of PCPA-induced …
Dose: Fushen Decoction 10, 20, and 40 g/kg; coffee 1 g/kg (PCPA-induced insomnia model)
vs: Placebo
Etki: None
None
Key Statistics
43
Çalışmalar
84
Katılımcılar
↑
Positive
B
Derece
Referenced Papers
Journal of ethnopharmacology
2026
Journal of ethnopharmacology
2025
9 atıf
Psychopharmacology
2025
5 atıf
Neuroscience letters
2025
3 atıf
International journal of …
2025
1 atıf
International immunopharmacology
2025
1 atıf
Zhongguo Zhong yao …
2025
Journal of ethnopharmacology
2024
26 atıf
International journal of …
2024
5 atıf
Bioorganic chemistry
2023
14 atıf
Child and adolescent …
2023
5 atıf
Microbial cell factories
2022
20 atıf
Frontiers in bioengineering …
2021
18 atıf
Food & function
2020
42 atıf
Applied microbiology and …
2020
30 atıf
Frontiers in pharmacology
2019
52 atıf
Pharmacotherapeutic management of sleep disorders in children with neurodevelopmental disorders.
Review
Expert opinion on …
2019
49 atıf
Study on the hypnotic effect of rare protopanaxadiol-type and protopanaxatriol-type ginsenosides.
Other
RSC advances
2019
13 atıf
RSC advances
2018
23 atıf
Nutrition research and …
2018
12 atıf
Life sciences
2016
19 atıf
Biomedical reports
2015
12 atıf
ACS synthetic biology
2014
71 atıf
Neurological sciences : …
2014
58 atıf
European journal of …
2014
43 atıf
Fitoterapia
2014
30 atıf
Journal of Huazhong …
2012
15 atıf
Symptomatic treatment of interferon-α-induced depression in hepatitis C: a systematic review.
Systematic Review
Journal of clinical …
2012
Medical science monitor …
2009
85 atıf
Neuropsychiatric disease and …
2009
31 atıf
Pharmacology, biochemistry, and …
2008
76 atıf
Journal of ethnopharmacology
2008
55 atıf
Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence.
Review
Journal of clinical …
2005
Primary care
2002
43 atıf
Brain research
2002
33 atıf
Alternative medicine review …
1998
216 atıf
Alternative medicine review …
1998
Experimental brain research
1991
20 atıf
Electroencephalography and clinical …
1984
2 atıf
Comptes rendus des …
1983
2 atıf
Restoration of paradoxical sleep by cerebrospinal fluid transfer to PCPA pretreated insomniac cats.
Other
Brain research
1982
38 atıf
European journal of …
1982
21 atıf
Brain research
1982
2 atıf
Comptes rendus des …
1980
1 atıf
Japanese journal of …
1977
17 atıf
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Yaygın Kullanılan Dozajlar
- sleep:
- 100-300 mg, 30-45 min before bed
Üst sınır: Not established; serotonin syndrome risk with SSRIs
Araştırmalarda İncelenen Dozajlar
| Dozaj | Süre | Etki | N |
|---|---|---|---|
| Guhan Yangsheng Jing (GHYSJ) multi-herbal decoction (dose not specified in abstract) | -- | Positive | -- |
| None | -- | Positive | -- |
| 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL | -- | Positive | -- |
| Cinnamic acid (CA) administered to rats (dose not specified) | -- | Positive | -- |
| None | -- | Positive | -- |
| Fushen Decoction 10, 20, and 40 g/kg; coffee 1 g/kg (PCPA-induced insomnia model) | -- | Positive | -- |
| 5-HTP encapsulated in β-cyclodextrin/corn starch composite nanoparticles (dose not specified) | -- | Positive | -- |
| None | -- | Positive | -- |
En iyi alım zamanı: 30-45 minutes before bed
Safety & Side Effects
Bildirilen Yan Etkiler
- ⚠ Nausea
- ⚠ Diarrhea
- ⚠ Heartburn
- ⚠ Stomach pain
- ⚠ Drowsiness
Bilinen Etkileşimler
- ● SSRIs/SNRIs — serious risk of serotonin syndrome
- ● MAOIs — dangerous serotonin accumulation
- ● Tramadol — increased serotonin syndrome risk
- ● Carbidopa — may cause scleroderma-like skin changes
Tolere edilebilir üst alım: Not established; serotonin syndrome risk with SSRIs
Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.
Frequently Asked Questions
Does 5-HTP help with Uykusuzluk?
Based on 43 studies with 84 participants, there is moderate evidence from clinical studies that 5-HTP may support Uykusuzluk management. Our evidence grade is B (Good Evidence).
How much 5-HTP should I take for Uykusuzluk?
Studies have used various dosages. A commonly studied range is 100-300 mg, 30-45 min before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 5-HTP?
Reported side effects may include Nausea, Diarrhea, Heartburn, Stomach pain. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 5-HTP and Uykusuzluk?
We rate the evidence as Grade B (Good Evidence). This rating is based on 43 peer-reviewed studies with 84 total participants. The overall direction of effect is positive.
Related Evidence
Şu durum için diğer içerikler: Uykusuzluk
5-HTP diğer sağlık durumları için
FDA Sorumluluk Reddi: Bu ifadeler Gıda ve İlaç Dairesi (FDA) tarafından değerlendirilmemiştir. Bu web sitesindeki ürünler ve bilgiler herhangi bir hastalığı teşhis etmek, tedavi etmek, iyileştirmek veya önlemek amacıyla tasarlanmamıştır. Sunulan kanıt dereceleri, yayımlanmış hakemli araştırmalarımızın analizine dayanmaktadır ve tıbbi tavsiye niteliği taşımamaktadır. Herhangi bir takviye rejimine başlamadan önce her zaman sağlık uzmanınıza danışın.