5-HTP para Insomnio
BBasado en 42 estudios (1 RCT) con 84 participantes en total. 35/42 estudios muestran efectos positivos.
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B
Conclusión
5-HTP may support better sleep through its role in serotonin and melatonin production, but human evidence remains limited despite strong preclinical results.
- 35 out of 42 studies show positive effects on sleep, but most are animal or lab studies
- 5-HTP is a natural precursor to serotonin and melatonin, key neurotransmitters for sleep regulation
- Only 1 randomized controlled trial (RCT) in humans has been conducted
- A GABA/5-HTP combination has shown sleep-promoting effects in preclinical models
Key Study Findings
animal study / preclinical
Guhan Yangsheng Jing alleviates sleep deprivation-induced neuronal injury via neurotransmitter rebalancing, mitochondrial protection, and inhibition …
Dose: Guhan Yangsheng Jing (GHYSJ) multi-herbal decoction (dose not specified in abstract)
vs: Placebo
Efecto: None
None
Other
Sleep deprivation activated AMPK/FOXO3a signaling mediates pineal autophagy impairment to reduce melatonin secretion in CUMS …
Dose: None
vs: CUMS+SD model without intervention
Outcome: Depression/insomnia behaviors and melatonin secretion
Efecto: None
None
Población: CUMS + sleep deprivation rat model
preclinical animal/in vitro study
Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …
Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL
vs: Placebo
Efecto: None
None
Animal Study
Promotion of sleep by cinnamic acid in parachlorophenylalanine-induced insomnia in rats.
Dose: Cinnamic acid (CA) administered to rats (dose not specified)
vs: Placebo
Efecto: None
None
Animal study
Ginsenoside Rg1 alleviates PCPA-induced insomnia by inhibiting NLRP3 inflammasome activation and pyroptosis through the Nrf2/HO-1 …
Dose: None
vs: Placebo
Efecto: None
None
animal study / preclinical
[Effect of Fushen Decoction on 5-HT system and GABA expression in mouse model of PCPA-induced …
Dose: Fushen Decoction 10, 20, and 40 g/kg; coffee 1 g/kg (PCPA-induced insomnia model)
vs: Placebo
Efecto: None
None
Key Statistics
43
Estudios
84
Participantes
↑
Positive
B
Calificación
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Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosificaciones de uso común
- sleep:
- 100-300 mg, 30-45 min before bed
Límite superior: Not established; serotonin syndrome risk with SSRIs
Dosificaciones estudiadas en la investigación
| Dosificación | Duración | Efecto | N |
|---|---|---|---|
| Guhan Yangsheng Jing (GHYSJ) multi-herbal decoction (dose not specified in abstract) | -- | Positive | -- |
| None | -- | Positive | -- |
| 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL | -- | Positive | -- |
| Cinnamic acid (CA) administered to rats (dose not specified) | -- | Positive | -- |
| None | -- | Positive | -- |
| Fushen Decoction 10, 20, and 40 g/kg; coffee 1 g/kg (PCPA-induced insomnia model) | -- | Positive | -- |
| 5-HTP encapsulated in β-cyclodextrin/corn starch composite nanoparticles (dose not specified) | -- | Positive | -- |
| None | -- | Positive | -- |
Mejor momento para tomar: 30-45 minutes before bed
Safety & Side Effects
Efectos secundarios reportados
- ⚠ Nausea
- ⚠ Diarrhea
- ⚠ Heartburn
- ⚠ Stomach pain
- ⚠ Drowsiness
Interacciones conocidas
- ● SSRIs/SNRIs — serious risk of serotonin syndrome
- ● MAOIs — dangerous serotonin accumulation
- ● Tramadol — increased serotonin syndrome risk
- ● Carbidopa — may cause scleroderma-like skin changes
Ingesta máxima tolerable: Not established; serotonin syndrome risk with SSRIs
Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.
Frequently Asked Questions
Does 5-HTP help with Insomnio?
Based on 43 studies with 84 participants, there is moderate evidence from clinical studies that 5-HTP may support Insomnio management. Our evidence grade is B (Good Evidence).
How much 5-HTP should I take for Insomnio?
Studies have used various dosages. A commonly studied range is 100-300 mg, 30-45 min before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 5-HTP?
Reported side effects may include Nausea, Diarrhea, Heartburn, Stomach pain. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 5-HTP and Insomnio?
We rate the evidence as Grade B (Good Evidence). This rating is based on 43 peer-reviewed studies with 84 total participants. The overall direction of effect is positive.
Related Evidence
Otros ingredientes para Insomnio
5-HTP para otras condiciones
Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.