Differential Diagnoses of Restless Legs Syndrome/Willis-Ekbom Disease: Mimics and Comorbidities.

Sudhansu Chokroverty

Review Sleep medicine clinics 2015 28 次引用

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Study Design

研究类型: Review
研究人群: restless legs syndrome patients

干预措施: Differential Diagnoses of Restless Legs Syndrome/Willis-Ekbom Disease: Mimics and Comorbidities. None
对照组: None
主要结局: None
效应方向: Mixed
偏倚风险: Unclear

Abstract

Restless legs syndrome (RLS) mimics cannot always be differentiated from RLS/Willis-Ekbom disease (WED) based on 4 essential criteria; hence, a fifth criterion has recently been established. RLS comorbidities may provide us important clues for understanding the neurobiology of RLS/WED. Iron-dopamine connection, hypoxia pathway activation, and dopamine-opioid interaction are important pathophysiological mechanisms in RLS; this knowledge is derived from our understanding of RLS associations with a variety of medical, neurologic, and other conditions. Clinicians must formulate an RLS differential diagnosis based on history and physical examination, but laboratory tests may sometimes be needed to arrive at a correct diagnosis.

简要概述

Iron-dopamine connection, hypoxia pathway activation, and dopamine-opioid interaction are important pathophysiological mechanisms in RLS; this knowledge is derived from understanding of RLS associations with a variety of medical, neurologic, and other conditions.

Used In Evidence Reviews

A 铁用于不宁腿综合征

Differential Diagnoses of Restless Legs Syndrome/Willis-Ekbom Disease: Mimics and Comorbidities.

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Study Design

Abstract

简要概述

Used In Evidence Reviews

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