Differential Diagnoses of Restless Legs Syndrome/Willis-Ekbom Disease: Mimics and Comorbidities.

Sudhansu Chokroverty

Review Sleep medicine clinics 2015 28 atıf

<\/script>\n

`; }, get iframeSnippet() { const domain = 'sleepcited.com'; const params = 'pmid\u003D26329435'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

Study Design

Çalışma Türü: Review
Popülasyon: restless legs syndrome patients

Müdahale: Differential Diagnoses of Restless Legs Syndrome/Willis-Ekbom Disease: Mimics and Comorbidities. None
Karşılaştırıcı: None
Birincil Sonuç: None
Etki Yönü: Mixed
Yanlılık Riski: Unclear

Abstract

Restless legs syndrome (RLS) mimics cannot always be differentiated from RLS/Willis-Ekbom disease (WED) based on 4 essential criteria; hence, a fifth criterion has recently been established. RLS comorbidities may provide us important clues for understanding the neurobiology of RLS/WED. Iron-dopamine connection, hypoxia pathway activation, and dopamine-opioid interaction are important pathophysiological mechanisms in RLS; this knowledge is derived from our understanding of RLS associations with a variety of medical, neurologic, and other conditions. Clinicians must formulate an RLS differential diagnosis based on history and physical examination, but laboratory tests may sometimes be needed to arrive at a correct diagnosis.

Kısaca

Iron-dopamine connection, hypoxia pathway activation, and dopamine-opioid interaction are important pathophysiological mechanisms in RLS; this knowledge is derived from understanding of RLS associations with a variety of medical, neurologic, and other conditions.

Used In Evidence Reviews

A Demir için Huzursuz Bacak Sendromu

Differential Diagnoses of Restless Legs Syndrome/Willis-Ekbom Disease: Mimics and Comorbidities.

Embed This Widget

Study Design

Abstract

Kısaca

Used In Evidence Reviews

Similar Papers

Dopamine and iron in the pathophysiology of restless legs syndrome (RLS).

Restless legs syndrome and pregnancy.

Treatment of restless legs syndrome: an evidence-based review and implications for clinical practice.

Restless legs syndrome: pathophysiology, clinical presentation and management.

Altered brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease).

Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation.