Differential Diagnoses of Restless Legs Syndrome/Willis-Ekbom Disease: Mimics and Comorbidities.

Sudhansu Chokroverty

Review Sleep medicine clinics 2015 28 citations

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Study Design

Type d'étude: Review
Population: restless legs syndrome patients

Intervention: Differential Diagnoses of Restless Legs Syndrome/Willis-Ekbom Disease: Mimics and Comorbidities. None
Comparateur: None
Critère de jugement principal: None
Direction de l'effet: Mixed
Risque de biais: Unclear

Abstract

Restless legs syndrome (RLS) mimics cannot always be differentiated from RLS/Willis-Ekbom disease (WED) based on 4 essential criteria; hence, a fifth criterion has recently been established. RLS comorbidities may provide us important clues for understanding the neurobiology of RLS/WED. Iron-dopamine connection, hypoxia pathway activation, and dopamine-opioid interaction are important pathophysiological mechanisms in RLS; this knowledge is derived from our understanding of RLS associations with a variety of medical, neurologic, and other conditions. Clinicians must formulate an RLS differential diagnosis based on history and physical examination, but laboratory tests may sometimes be needed to arrive at a correct diagnosis.

En bref

Iron-dopamine connection, hypoxia pathway activation, and dopamine-opioid interaction are important pathophysiological mechanisms in RLS; this knowledge is derived from understanding of RLS associations with a variety of medical, neurologic, and other conditions.

Used In Evidence Reviews

A Fer pour Syndrome des Jambes Sans Repos

Differential Diagnoses of Restless Legs Syndrome/Willis-Ekbom Disease: Mimics and Comorbidities.

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Study Design

Abstract

En bref

Used In Evidence Reviews

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