酸樱桃 用于 睡眠维持性失眠
A 证据 多项大型临床试验一致显示出显著的益处。基于27项研究（3项荟萃分析、11项RCT），共7,254名参与者。14/27项研究显示积极效果。
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A
结论
Tart cherry may help some people stay asleep longer, supported by a moderate body of evidence, though results vary and it may not work for everyone.
- 27 studies including 3 meta-analyses and 11 RCTs — a substantial evidence base
- About 52% of studies show positive effects on staying asleep
- Contains natural melatonin and anti-inflammatory compounds that may support longer sleep
- Effectiveness may vary depending on the person and tart cherry preparation
Key Study Findings
review
Nutritional Supplements for Healthy Aging: A Critical Analysis Review.
Dose: None
vs: Placebo
效果: None
None
Review
Selenized non-Saccharomyces yeasts and their potential use in fish feed.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
In Vitro
Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact.
Dose: L. plantarum JGR2 serial passages
vs: Ancestral strain
Outcome: Phenotypic and genomic changes
效果: None
None
研究人群: In vitro bacterial culture study
randomized controlled trial
n=34
2 weeks
Double-blind
Commonly Used Dose of Montmorency Tart Cherry Powder Does Not Improve Sleep or Inflammation Outcomes …
Dose: Montmorency tart cherry (MTC) powder 500 mg capsule once daily, 1 hour before bed for 14 days
vs: Placebo
效果: No significant effects (p > 0.05 for all outcomes)
>0.05
Other
12 weeks
Can selenium-enriched spirulina supplementation ameliorate sepsis outcomes in selenium-deficient animals?
Dose: 92%
vs: None
Outcome: by ICPMS
效果: or 4
None
研究人群: None
Other
n=544
12 weeks
Plasma mineral (selenium, zinc or copper) concentrations in the general pregnant population, adjusted for supplement …
Dose: 25 µmol
vs: None
Outcome: None
效果: None
None
研究人群: pregnant women
Key Statistics
27
研究数量
9058
受试者
↔
Mixed
A
等级
Referenced Papers
American journal of …
2025
6 次引用
Fish physiology and …
2024
5 次引用
Nutrients
2024
1 次引用
Journal of applied …
2024
1 次引用
Biological trace element …
2021
18 次引用
The British journal …
2021
14 次引用
Physiological reports
2021
3 次引用
Acta psychiatrica Scandinavica
2020
51 次引用
Animal : an …
2020
27 次引用
Journal of basic …
2020
14 次引用
Nutrients
2019
15 次引用
Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia and Investigation of Mechanisms.
RCT
American journal of …
2018
61 次引用
Food chemistry
2017
82 次引用
The British journal …
2017
6 次引用
Multiple micronutrient supplementation and birth outcomes: The potential importance of selenium.
Review
Placenta
2016
23 次引用
Biological trace element …
2015
1 次引用
Dietary supplements for established atopic eczema.
Meta-Analysis
The Cochrane database …
2012
130 次引用
Molecular nutrition & …
2012
65 次引用
Biological trace element …
2012
31 次引用
Alcoholism, clinical and …
2012
19 次引用
Nutrition and cancer
2011
19 次引用
European review for …
2011
9 次引用
Effects of a tart cherry juice beverage on the sleep of older adults with insomnia: a pilot study.
RCT
Journal of medicinal …
2010
157 次引用
Critical reviews in …
2009
Nutrition in clinical …
2008
125 次引用
Journal of agricultural …
2007
44 次引用
Journal of the …
2001
237 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- sleep:
- 480 mL juice or 480 mg concentrate, twice daily
上限： Not established
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Neutral | -- |
| L. plantarum JGR2 serial passages | -- | Neutral | -- |
| Montmorency tart cherry (MTC) powder 500 mg capsule once daily, 1 hour before bed for 14 days | 2 weeks | Neutral | 34 |
| 92% | 12 weeks | Positive | -- |
| 25 µmol | 12 weeks | Positive | 544 |
| 0.16 μg | 1 weeks | Positive | 216 |
| 1,300 µg | -- | Neutral | -- |
最佳服用时间： Morning and evening (twice daily dosing studied)
Safety & Side Effects
已报告的副作用
- ⚠ GI discomfort
- ⚠ Diarrhea (high sugar content in juice)
- ⚠ Weight gain from caloric intake
已知相互作用
- ● Blood thinners — cherry anthocyanins may have mild antiplatelet effects
- ● Diabetes medications — juice form contains significant sugars
可耐受最高摄入量： Not established
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does 酸樱桃 help with 睡眠维持性失眠?
Based on 27 studies with 9,058 participants, there is strong evidence from multiple clinical trials that 酸樱桃 may support 睡眠维持性失眠 management. Our evidence grade is A (Strong Evidence).
How much 酸樱桃 should I take for 睡眠维持性失眠?
Studies have used various dosages. A commonly studied range is 480 mL juice or 480 mg concentrate, twice daily. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 酸樱桃?
Reported side effects may include GI discomfort, Diarrhea (high sugar content in juice), Weight gain from caloric intake. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 酸樱桃 and 睡眠维持性失眠?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 27 peer-reviewed studies with 9,058 total participants. The overall direction of effect is mixed.
Related Evidence
References
- [1] Matthew W Kaufman et al.. Am J Lifestyle Med. 2025. Nutritional Supplements for Healthy Aging: A Critical Analysis Review. doi:10.1177/15598276241244725 PubMed
- [2] Paola Díaz-Navarrete et al.. Fish Physiol Biochem. 2024. Selenized non-Saccharomyces yeasts and their potential use in fish feed. doi:10.1007/s10695-024-01340-7 PubMed
- [3] Robin M Tucker et al.. Nutrients. 2024. Commonly Used Dose of Montmorency Tart Cherry Powder Does Not Improve Sleep or Inflammation Outcomes in Individuals with Overweight or … doi:10.3390/nu16234125 PubMed
- [4] Sarvesh V Surve et al.. J Appl Microbiol. 2024. Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact. doi:10.1093/jambio/lxae035 PubMed
- [5] Tian-Tian Meng et al.. Biol Trace Elem Res. 2021. Nanoselenium and Selenium Yeast Have Minimal Differences on Egg Production and Se Deposition in Laying Hens. doi:10.1007/s12011-020-02349-8 PubMed
- [6] Victor Pop et al.. Br J Nutr. 2021. Plasma mineral (selenium, zinc or copper) concentrations in the general pregnant population, adjusted for supplement intake, in relation to thyroid … doi:10.1017/S000711452000255X PubMed
- [7] Thomas Castel et al.. Physiol Rep. 2021. Can selenium-enriched spirulina supplementation ameliorate sepsis outcomes in selenium-deficient animals? doi:10.14814/phy2.14933 PubMed
- [8] M T Samara et al.. Acta Psychiatr Scand. 2020. Efficacy, acceptability, and tolerability of all available treatments for insomnia in the elderly: a systematic review and network meta-analysis. doi:10.1111/acps.13201 PubMed
- [9] J S Silva et al.. Animal. 2020. Performance, carcass characteristics and meat quality of Nellore cattle supplemented with supranutritional doses of sodium selenite or selenium-enriched yeast. doi:10.1017/S1751731119001265 PubMed
- [10] Dunja Miletić et al.. J Basic Microbiol. 2020. Influence of selenium yeast on the growth, selenium uptake and mineral composition of Coriolus versicolor mushroom. doi:10.1002/jobm.201900520 PubMed
- [11] Nishi Karunasinghe et al.. Nutrients. 2019. Selenium Supplementation and Prostate Health in a New Zealand Cohort. doi:10.3390/nu12010002 PubMed
- [12] Jack N Losso et al.. Am J Ther. 2018. Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia and Investigation of Mechanisms. doi:10.1097/MJT.0000000000000584 PubMed
- [13] Kevin M Kubachka et al.. Food Chem. 2017. Evaluation of selenium in dietary supplements using elemental speciation. doi:10.1016/j.foodchem.2016.08.086 PubMed
- [14] Jiyoung Jang et al.. Br J Nutr. 2017. Toenail selenium levels and prevalence of dyslipidaemia among Korean adults. doi:10.1017/S0007114517002343 PubMed
- [15] Anthony V Perkins et al.. Placenta. 2016. Multiple micronutrient supplementation and birth outcomes: The potential importance of selenium. doi:10.1016/j.placenta.2016.02.007 PubMed
- [16] Mahmood Habibian et al.. Biol Trace Elem Res. 2015. Selenium as a feed supplement for heat-stressed poultry: a review. doi:10.1007/s12011-015-0275-x PubMed
- [17] Fiona J Bath-Hextall et al.. Cochrane Database Syst Rev. 2012. Dietary supplements for established atopic eczema. doi:10.1002/14651858.CD005205.pub3 PubMed
- [18] Nicole Metes-Kosik et al.. Mol Nutr Food Res. 2012. Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance. doi:10.1002/mnfr.201200386 PubMed
- [19] Huimin Yan et al.. Biol Trace Elem Res. 2012. Antioxidant and antitumor activities of selenium- and zinc-enriched oyster mushroom in mice. doi:10.1007/s12011-012-9454-1 PubMed
- [20] Maria Luisa Ojeda et al.. Alcohol Clin Exp Res. 2012. Selenium or selenium plus folic acid-supplemented diets ameliorate renal oxidation in ethanol-exposed pups. doi:10.1111/j.1530-0277.2012.01788.x PubMed
- [21] John P Richie et al.. Nutr Cancer. 2011. Association of selenium status and blood glutathione concentrations in blacks and whites. doi:10.1080/01635581.2011.535967 PubMed
- [22] E Papaleo et al.. Eur Rev Med Pharmacol Sci. 2011. Nutrients and infertility: an alternative perspective. PubMed
- [23] Wilfred R Pigeon et al.. J Med Food. 2010. Effects of a tart cherry juice beverage on the sleep of older adults with insomnia: a pilot study. doi:10.1089/jmf.2009.0096 PubMed
- [24] Gerhard N Schrauzer et al.. Crit Rev Biotechnol. 2009. Selenium in human and animal nutrition: resolved and unresolved issues. A partly historical treatise in commemoration of the fiftieth anniversary … doi:10.1080/07388550902728261 PubMed
- [25] Maria G Boosalis. Nutr Clin Pract. 2008. The role of selenium in chronic disease. doi:10.1177/0884533608314532 PubMed
- [26] Gabriel A Agbor et al.. J Agric Food Chem. 2007. Effect of selenium- and glutathione-enriched yeast supplementation on a combined atherosclerosis and diabetes hamster model. doi:10.1021/jf0711901 PubMed
- [27] G N Schrauzer. J Am Coll Nutr. 2001. Nutritional selenium supplements: product types, quality, and safety. doi:10.1080/07315724.2001.10719007 PubMed
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